Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages

Detalhes bibliográficos
Autor(a) principal: Reis-Sobreiro, Mariana
Data de Publicação: 2021
Outros Autores: Teixeira da Mota, Afonso, Jardim, Carolina, Serre, Karine
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49865
Resumo: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophagesAntitumor functionsMacrophagesMyeloid-targeted therapiesReprogramming© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Macrophages are found in all tissues and display outstanding functional diversity. From embryo to birth and throughout adult life, they play critical roles in development, homeostasis, tissue repair, immunity, and, importantly, in the control of cancer growth. In this review, we will briefly detail the multi-functional, protumoral, and antitumoral roles of macrophages in the tumor microenvironment. Our objective is to focus on the ever-growing therapeutic opportunities, with promising preclinical and clinical results developed in recent years, to modulate the contribution of macrophages in oncologic diseases. While the majority of cancer immunotherapies target T cells, we believe that macrophages have a promising therapeutic potential as tumoricidal effectors and in mobilizing their surroundings towards antitumor immunity to efficiently limit cancer progression.This work was supported by an iMM-Laço research grant and the Fundacão para a Ciência e Tecnologia through a research grant (PTDC/MED-IMU/30948/2017) and a personal fellowship (CEECIND/00697/2018) received by K.S. and a PhD fellowship (SFRH/BD/144792/2019) to C.J. This work was also kindly backed by the COST Action BM1404 Mye-EUNITER (http://www.mye-euniter.eu accessed on 26 November 2018). COST is supported by the EU Framework Program Horizon 2020.MDPIRepositório da Universidade de LisboaReis-Sobreiro, MarianaTeixeira da Mota, AfonsoJardim, CarolinaSerre, Karine2021-10-12T14:07:21Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49865engCells. 2021 Sep 9;10(9):236410.3390/cells100923642073-4409info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:47Zoai:repositorio.ul.pt:10451/49865Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:23.079350Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
title Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
spellingShingle Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
Reis-Sobreiro, Mariana
Antitumor functions
Macrophages
Myeloid-targeted therapies
Reprogramming
title_short Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
title_full Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
title_fullStr Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
title_full_unstemmed Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
title_sort Bringing macrophages to the frontline against cancer: current Immunotherapies targeting macrophages
author Reis-Sobreiro, Mariana
author_facet Reis-Sobreiro, Mariana
Teixeira da Mota, Afonso
Jardim, Carolina
Serre, Karine
author_role author
author2 Teixeira da Mota, Afonso
Jardim, Carolina
Serre, Karine
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Reis-Sobreiro, Mariana
Teixeira da Mota, Afonso
Jardim, Carolina
Serre, Karine
dc.subject.por.fl_str_mv Antitumor functions
Macrophages
Myeloid-targeted therapies
Reprogramming
topic Antitumor functions
Macrophages
Myeloid-targeted therapies
Reprogramming
description © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-10-12T14:07:21Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49865
url http://hdl.handle.net/10451/49865
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cells. 2021 Sep 9;10(9):2364
10.3390/cells10092364
2073-4409
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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