Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery

Detalhes bibliográficos
Autor(a) principal: Moreira, André
Data de Publicação: 2014
Outros Autores: Gaspar, Vítor Manuel Abreu, Costa, Elisabete C., Diogo, Duarte Miguel de Melo, Machado, Paulo Filipe Brito, Paquete, Catarina, Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4659
Resumo: Nanocarriers with a pH responsive behavior are receiving an ever growing attention due to their potential for promoting on-demand drug release and thus increase the therapeutic effectiveness of anti-tumoral pharmaceutics. However, the majority of these systems require costly, time-consuming and complex chemical modifications of materials or drugs to synthesize nanoparticles with pH triggered release. Herein, the development of dual drug loaded pH-responsive mesoporous silica nanoparticles (MSNs) with a calcium carbonate-based coating is presented as an effective alternative. This innovative approach allowed the loading of a non-steroidal anti-inflammatory drug (Ibuprofen) and Doxorubicin, with high efficiency. The resulting dual drug loaded MSNs have spherical morphology and a mean size of 171 nm. Our results indicate that under acidic conditions the coating disassembles and the drugs are rapidly released, whereas at physiologic pH the release is slower and gradually increases with time. Furthermore, an improved cytotoxic effect was obtained for Doxorubicin–Ibuprofen MSNs coated with CaCO3 in comparison with non-coated particles. The cytotoxic effect of dual loaded carbonate coated particles, was similar to that of Doxorubicin + Ibuprofen free drug administration at 72 h, even with the delivery of a significantly lower amount of drug by MSNs-CaCO3. These results suggest that the carbonate coating of MSNs is a promising approach to create a pH-sensitive template for a delivery system with application in cancer therapy.
id RCAP_9ab16e82481871acb0e0769e55931383
oai_identifier_str oai:ubibliorum.ubi.pt:10400.6/4659
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug deliveryCalcium carbonateCancer therapyCo-deliveryInorganic nanoparticlesPH responsiveProstate cancerNanocarriers with a pH responsive behavior are receiving an ever growing attention due to their potential for promoting on-demand drug release and thus increase the therapeutic effectiveness of anti-tumoral pharmaceutics. However, the majority of these systems require costly, time-consuming and complex chemical modifications of materials or drugs to synthesize nanoparticles with pH triggered release. Herein, the development of dual drug loaded pH-responsive mesoporous silica nanoparticles (MSNs) with a calcium carbonate-based coating is presented as an effective alternative. This innovative approach allowed the loading of a non-steroidal anti-inflammatory drug (Ibuprofen) and Doxorubicin, with high efficiency. The resulting dual drug loaded MSNs have spherical morphology and a mean size of 171 nm. Our results indicate that under acidic conditions the coating disassembles and the drugs are rapidly released, whereas at physiologic pH the release is slower and gradually increases with time. Furthermore, an improved cytotoxic effect was obtained for Doxorubicin–Ibuprofen MSNs coated with CaCO3 in comparison with non-coated particles. The cytotoxic effect of dual loaded carbonate coated particles, was similar to that of Doxorubicin + Ibuprofen free drug administration at 72 h, even with the delivery of a significantly lower amount of drug by MSNs-CaCO3. These results suggest that the carbonate coating of MSNs is a promising approach to create a pH-sensitive template for a delivery system with application in cancer therapy.ElsevieruBibliorumMoreira, AndréGaspar, Vítor Manuel AbreuCosta, Elisabete C.Diogo, Duarte Miguel de MeloMachado, Paulo Filipe BritoPaquete, CatarinaCorreia, Ilídio Joaquim Sobreira2018-03-20T14:43:04Z2014-09-162014-09-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4659engMoreira, A.F., Gaspar, V.M., Costa, E.C., De Melo-Diogo, D., Machado, P., Paquete, C.M. e Correia, I.J. (2014) “Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery”, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 88 (3), pp. 1012-102510.1016/j.ejpb.2014.09.002metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:41:52Zoai:ubibliorum.ubi.pt:10400.6/4659Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:43.065696Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
title Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
spellingShingle Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
Moreira, André
Calcium carbonate
Cancer therapy
Co-delivery
Inorganic nanoparticles
PH responsive
Prostate cancer
title_short Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
title_full Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
title_fullStr Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
title_full_unstemmed Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
title_sort Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery
author Moreira, André
author_facet Moreira, André
Gaspar, Vítor Manuel Abreu
Costa, Elisabete C.
Diogo, Duarte Miguel de Melo
Machado, Paulo Filipe Brito
Paquete, Catarina
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Gaspar, Vítor Manuel Abreu
Costa, Elisabete C.
Diogo, Duarte Miguel de Melo
Machado, Paulo Filipe Brito
Paquete, Catarina
Correia, Ilídio Joaquim Sobreira
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Moreira, André
Gaspar, Vítor Manuel Abreu
Costa, Elisabete C.
Diogo, Duarte Miguel de Melo
Machado, Paulo Filipe Brito
Paquete, Catarina
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv Calcium carbonate
Cancer therapy
Co-delivery
Inorganic nanoparticles
PH responsive
Prostate cancer
topic Calcium carbonate
Cancer therapy
Co-delivery
Inorganic nanoparticles
PH responsive
Prostate cancer
description Nanocarriers with a pH responsive behavior are receiving an ever growing attention due to their potential for promoting on-demand drug release and thus increase the therapeutic effectiveness of anti-tumoral pharmaceutics. However, the majority of these systems require costly, time-consuming and complex chemical modifications of materials or drugs to synthesize nanoparticles with pH triggered release. Herein, the development of dual drug loaded pH-responsive mesoporous silica nanoparticles (MSNs) with a calcium carbonate-based coating is presented as an effective alternative. This innovative approach allowed the loading of a non-steroidal anti-inflammatory drug (Ibuprofen) and Doxorubicin, with high efficiency. The resulting dual drug loaded MSNs have spherical morphology and a mean size of 171 nm. Our results indicate that under acidic conditions the coating disassembles and the drugs are rapidly released, whereas at physiologic pH the release is slower and gradually increases with time. Furthermore, an improved cytotoxic effect was obtained for Doxorubicin–Ibuprofen MSNs coated with CaCO3 in comparison with non-coated particles. The cytotoxic effect of dual loaded carbonate coated particles, was similar to that of Doxorubicin + Ibuprofen free drug administration at 72 h, even with the delivery of a significantly lower amount of drug by MSNs-CaCO3. These results suggest that the carbonate coating of MSNs is a promising approach to create a pH-sensitive template for a delivery system with application in cancer therapy.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-16
2014-09-16T00:00:00Z
2018-03-20T14:43:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4659
url http://hdl.handle.net/10400.6/4659
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moreira, A.F., Gaspar, V.M., Costa, E.C., De Melo-Diogo, D., Machado, P., Paquete, C.M. e Correia, I.J. (2014) “Preparation of end-capped pH-sensitive mesoporous silica nanocarriers for on-demand drug delivery”, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 88 (3), pp. 1012-1025
10.1016/j.ejpb.2014.09.002
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799136354469150720