Yeast as a tool to explore cathepsin D function
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/50170 |
Resumo: | Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may constitute a therapeutic target. However, cathepsin D can have both anti- and pro-survival functions depending on its proteolytic activity, cellular context and stress stimulus. Therefore, a more detailed understanding of cathepsin D regulation and how to modulate its apoptotic functions is clearly needed. In this review, we provide an overview of the role of cathepsin D in physiological and pathological scenarios. We then focus on the opposing functions of cathepsin D in apoptosis, particularly relevant in cancer research. Emphasis is given to the role of the yeast protease Pep4p, the vacuolar counterpart of cathepsin D, in life and death. Finally, we discuss how insights from yeast cathepsin D and its role in regulated cell death can unveil novel functions of mammalian cathepsin D in apoptosis and cancer. |
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Yeast as a tool to explore cathepsin D functioncathepsin Dyeast modelapoptosisyeast cathepsin DcancerCiências Naturais::Ciências BiológicasScience & TechnologyCathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may constitute a therapeutic target. However, cathepsin D can have both anti- and pro-survival functions depending on its proteolytic activity, cellular context and stress stimulus. Therefore, a more detailed understanding of cathepsin D regulation and how to modulate its apoptotic functions is clearly needed. In this review, we provide an overview of the role of cathepsin D in physiological and pathological scenarios. We then focus on the opposing functions of cathepsin D in apoptosis, particularly relevant in cancer research. Emphasis is given to the role of the yeast protease Pep4p, the vacuolar counterpart of cathepsin D, in life and death. Finally, we discuss how insights from yeast cathepsin D and its role in regulated cell death can unveil novel functions of mammalian cathepsin D in apoptosis and cancer.FEDER through POFC – COMPETE and by Fundação para a Ciência e Tecnologia through projects PEst-OE/BIA/UI4050/2014 and FCTANR/BEX-BCM/0175/2012, as well as fellowships to H. Pereira (SFRH/BD/73139/2010), C.S.F. Oliveira (SFRH/BD/77449/2011), L. Castro (SFRH/BD/93589/2013) and S. Chaves (SFRH/ BPD/89980/2012).info:eu-repo/semantics/publishedVersionShared Science PublishersUniversidade do MinhoPereira, HOliveira, C S FCastro, L.Preto, AnaChaves, S. R.Côrte-Real, Manuela2015-07-112015-07-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/50170eng2311-26382311-263810.15698/mic2015.07.212info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:24:02ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Yeast as a tool to explore cathepsin D function |
title |
Yeast as a tool to explore cathepsin D function |
spellingShingle |
Yeast as a tool to explore cathepsin D function Pereira, H cathepsin D yeast model apoptosis yeast cathepsin D cancer Ciências Naturais::Ciências Biológicas Science & Technology |
title_short |
Yeast as a tool to explore cathepsin D function |
title_full |
Yeast as a tool to explore cathepsin D function |
title_fullStr |
Yeast as a tool to explore cathepsin D function |
title_full_unstemmed |
Yeast as a tool to explore cathepsin D function |
title_sort |
Yeast as a tool to explore cathepsin D function |
author |
Pereira, H |
author_facet |
Pereira, H Oliveira, C S F Castro, L. Preto, Ana Chaves, S. R. Côrte-Real, Manuela |
author_role |
author |
author2 |
Oliveira, C S F Castro, L. Preto, Ana Chaves, S. R. Côrte-Real, Manuela |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pereira, H Oliveira, C S F Castro, L. Preto, Ana Chaves, S. R. Côrte-Real, Manuela |
dc.subject.por.fl_str_mv |
cathepsin D yeast model apoptosis yeast cathepsin D cancer Ciências Naturais::Ciências Biológicas Science & Technology |
topic |
cathepsin D yeast model apoptosis yeast cathepsin D cancer Ciências Naturais::Ciências Biológicas Science & Technology |
description |
Cathepsin D has garnered increased attention in recent years, mainly since it has been associated with several human pathologies. In particular, cathepsin D is often overexpressed and hypersecreted in cancer cells, implying it may constitute a therapeutic target. However, cathepsin D can have both anti- and pro-survival functions depending on its proteolytic activity, cellular context and stress stimulus. Therefore, a more detailed understanding of cathepsin D regulation and how to modulate its apoptotic functions is clearly needed. In this review, we provide an overview of the role of cathepsin D in physiological and pathological scenarios. We then focus on the opposing functions of cathepsin D in apoptosis, particularly relevant in cancer research. Emphasis is given to the role of the yeast protease Pep4p, the vacuolar counterpart of cathepsin D, in life and death. Finally, we discuss how insights from yeast cathepsin D and its role in regulated cell death can unveil novel functions of mammalian cathepsin D in apoptosis and cancer. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-07-11 2015-07-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/50170 |
url |
http://hdl.handle.net/1822/50170 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2311-2638 2311-2638 10.15698/mic2015.07.212 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Shared Science Publishers |
publisher.none.fl_str_mv |
Shared Science Publishers |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303748291330048 |