Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal

Detalhes bibliográficos
Autor(a) principal: Nogueira, Célia
Data de Publicação: 2017
Outros Autores: Mota, Marta, Gradiz, Rui, Cipriano, Maria Augusta, Caramelo, Francisco, Cruz, Hugo, Alarcão, Ana, Castro-Sousa, Francisco, Oliveira, Fernando, Martinho, Fernando, Pereira, João Moura, Figueiredo, Paulo, Leitão, Maximino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/108212
https://doi.org/10.1186/s13027-017-0151-8
Resumo: Background: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. Methods: In the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs). The status of H. pylori infection was assessed by serology and by PCR. Results: EBV was detected by PCR in 90.2% of stomach cancer cases, whereas EBERs were detected in 11%. In our series, EBV-associated gastric carcinoma (EBVaGC) were significantly associated with gender and the majority of them presented lymph node metastasis. These cases were generally graded in more advanced pTNM stages and, non-surprisingly, showed worse survival. H. pylori infection was detected in 62.2% of the gastric cancers and 64.7% of these patients were CagA+. On the other hand, the H. pylori prevalence was higher in the EBV-negative gastric carcinomas (64.4%) than in those carcinoma cases with EBV+ (44.4%). Conclusions: The present study shows that prevalence of EBVaGC among Portuguese population is in accordance with the worldwide prevalence. EBV infection seems to be associated to poorer prognostic and no relation to H. pylori infection has been found. Conversely, the presence of H. pylori seems to have a favourable impact on patient’s survival. Our results emphasize that geographic variation can contribute with new epidemiological data on the association of EBV with gastric cancer.
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spelling Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in PortugalGastric cancerEpstein-Barr virusHelicobacter pyloriClinicopathologic featurePrognosisBackground: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. Methods: In the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs). The status of H. pylori infection was assessed by serology and by PCR. Results: EBV was detected by PCR in 90.2% of stomach cancer cases, whereas EBERs were detected in 11%. In our series, EBV-associated gastric carcinoma (EBVaGC) were significantly associated with gender and the majority of them presented lymph node metastasis. These cases were generally graded in more advanced pTNM stages and, non-surprisingly, showed worse survival. H. pylori infection was detected in 62.2% of the gastric cancers and 64.7% of these patients were CagA+. On the other hand, the H. pylori prevalence was higher in the EBV-negative gastric carcinomas (64.4%) than in those carcinoma cases with EBV+ (44.4%). Conclusions: The present study shows that prevalence of EBVaGC among Portuguese population is in accordance with the worldwide prevalence. EBV infection seems to be associated to poorer prognostic and no relation to H. pylori infection has been found. Conversely, the presence of H. pylori seems to have a favourable impact on patient’s survival. Our results emphasize that geographic variation can contribute with new epidemiological data on the association of EBV with gastric cancer.Springer Nature2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108212http://hdl.handle.net/10316/108212https://doi.org/10.1186/s13027-017-0151-8eng1750-9378Nogueira, CéliaMota, MartaGradiz, RuiCipriano, Maria AugustaCaramelo, FranciscoCruz, HugoAlarcão, AnaCastro-Sousa, FranciscoOliveira, FernandoMartinho, FernandoPereira, João MouraFigueiredo, PauloLeitão, Maximinoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-18T08:35:02Zoai:estudogeral.uc.pt:10316/108212Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:24:29.802673Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
title Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
spellingShingle Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
Nogueira, Célia
Gastric cancer
Epstein-Barr virus
Helicobacter pylori
Clinicopathologic feature
Prognosis
title_short Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
title_full Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
title_fullStr Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
title_full_unstemmed Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
title_sort Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal
author Nogueira, Célia
author_facet Nogueira, Célia
Mota, Marta
Gradiz, Rui
Cipriano, Maria Augusta
Caramelo, Francisco
Cruz, Hugo
Alarcão, Ana
Castro-Sousa, Francisco
Oliveira, Fernando
Martinho, Fernando
Pereira, João Moura
Figueiredo, Paulo
Leitão, Maximino
author_role author
author2 Mota, Marta
Gradiz, Rui
Cipriano, Maria Augusta
Caramelo, Francisco
Cruz, Hugo
Alarcão, Ana
Castro-Sousa, Francisco
Oliveira, Fernando
Martinho, Fernando
Pereira, João Moura
Figueiredo, Paulo
Leitão, Maximino
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nogueira, Célia
Mota, Marta
Gradiz, Rui
Cipriano, Maria Augusta
Caramelo, Francisco
Cruz, Hugo
Alarcão, Ana
Castro-Sousa, Francisco
Oliveira, Fernando
Martinho, Fernando
Pereira, João Moura
Figueiredo, Paulo
Leitão, Maximino
dc.subject.por.fl_str_mv Gastric cancer
Epstein-Barr virus
Helicobacter pylori
Clinicopathologic feature
Prognosis
topic Gastric cancer
Epstein-Barr virus
Helicobacter pylori
Clinicopathologic feature
Prognosis
description Background: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein–Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. Methods: In the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs). The status of H. pylori infection was assessed by serology and by PCR. Results: EBV was detected by PCR in 90.2% of stomach cancer cases, whereas EBERs were detected in 11%. In our series, EBV-associated gastric carcinoma (EBVaGC) were significantly associated with gender and the majority of them presented lymph node metastasis. These cases were generally graded in more advanced pTNM stages and, non-surprisingly, showed worse survival. H. pylori infection was detected in 62.2% of the gastric cancers and 64.7% of these patients were CagA+. On the other hand, the H. pylori prevalence was higher in the EBV-negative gastric carcinomas (64.4%) than in those carcinoma cases with EBV+ (44.4%). Conclusions: The present study shows that prevalence of EBVaGC among Portuguese population is in accordance with the worldwide prevalence. EBV infection seems to be associated to poorer prognostic and no relation to H. pylori infection has been found. Conversely, the presence of H. pylori seems to have a favourable impact on patient’s survival. Our results emphasize that geographic variation can contribute with new epidemiological data on the association of EBV with gastric cancer.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/108212
http://hdl.handle.net/10316/108212
https://doi.org/10.1186/s13027-017-0151-8
url http://hdl.handle.net/10316/108212
https://doi.org/10.1186/s13027-017-0151-8
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dc.relation.none.fl_str_mv 1750-9378
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dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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