Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics

Detalhes bibliográficos
Autor(a) principal: Petit, Robert Gironés
Data de Publicação: 2021
Outros Autores: Cano, Amanda, Ortiz, Alba, Espina, Marta, Prat, Josefina, Muñoz, Montserrat, Severino, Patrícia, Souto, Eliana B., García, Maria L., Pujol, Montserrat, Sánchez-López, Elena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/72611
Resumo: Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.
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spelling Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeuticsSkin inflammatory diseasesPsoriasisPsoriasis versus atopic dermatitisBiodegradable nanoparticlesMicroneedlesClinical trialsScience & TechnologyResearch in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE), under the project reference UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020, granted to EBS.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoPetit, Robert GironésCano, AmandaOrtiz, AlbaEspina, MartaPrat, JosefinaMuñoz, MontserratSeverino, PatríciaSouto, Eliana B.García, Maria L.Pujol, MontserratSánchez-López, Elena2021-05-072021-05-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/72611engPetit, Robert Gironés; Cano, Amanda; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Severino, Patrícia; Souto, Eliana; García, Maria L.; Pujol, Montserrat; Sánchez-López, Elena, Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics. International Journal of Molecular Sciences, 22(9), 4983, 20211424-67831422-006710.3390/ijms2209498334067151https://www.mdpi.com/1422-0067/22/9/4983info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:04:19Zoai:repositorium.sdum.uminho.pt:1822/72611Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:54:36.449127Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
title Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
spellingShingle Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
Petit, Robert Gironés
Skin inflammatory diseases
Psoriasis
Psoriasis versus atopic dermatitis
Biodegradable nanoparticles
Microneedles
Clinical trials
Science & Technology
title_short Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
title_full Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
title_fullStr Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
title_full_unstemmed Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
title_sort Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics
author Petit, Robert Gironés
author_facet Petit, Robert Gironés
Cano, Amanda
Ortiz, Alba
Espina, Marta
Prat, Josefina
Muñoz, Montserrat
Severino, Patrícia
Souto, Eliana B.
García, Maria L.
Pujol, Montserrat
Sánchez-López, Elena
author_role author
author2 Cano, Amanda
Ortiz, Alba
Espina, Marta
Prat, Josefina
Muñoz, Montserrat
Severino, Patrícia
Souto, Eliana B.
García, Maria L.
Pujol, Montserrat
Sánchez-López, Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Petit, Robert Gironés
Cano, Amanda
Ortiz, Alba
Espina, Marta
Prat, Josefina
Muñoz, Montserrat
Severino, Patrícia
Souto, Eliana B.
García, Maria L.
Pujol, Montserrat
Sánchez-López, Elena
dc.subject.por.fl_str_mv Skin inflammatory diseases
Psoriasis
Psoriasis versus atopic dermatitis
Biodegradable nanoparticles
Microneedles
Clinical trials
Science & Technology
topic Skin inflammatory diseases
Psoriasis
Psoriasis versus atopic dermatitis
Biodegradable nanoparticles
Microneedles
Clinical trials
Science & Technology
description Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.
publishDate 2021
dc.date.none.fl_str_mv 2021-05-07
2021-05-07T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/72611
url http://hdl.handle.net/1822/72611
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Petit, Robert Gironés; Cano, Amanda; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Severino, Patrícia; Souto, Eliana; García, Maria L.; Pujol, Montserrat; Sánchez-López, Elena, Psoriasis: from pathogenesis to pharmacological and nano-technological-based therapeutics. International Journal of Molecular Sciences, 22(9), 4983, 2021
1424-6783
1422-0067
10.3390/ijms22094983
34067151
https://www.mdpi.com/1422-0067/22/9/4983
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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