Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/104747 https://doi.org/10.3390/ijms22094983 |
Resumo: | Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases. |
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Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeuticsskin inflammatory diseasespsoriasispsoriasis versus atopic dermatitisbiodegradable nanoparticlesmicroneedlesclinical trialsAnimalsClinical Trials as TopicHumansModels, BiologicalNanotechnologyPsoriasisNanomedicineResearch in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases.MDPI AG2021-05-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/104747http://hdl.handle.net/10316/104747https://doi.org/10.3390/ijms22094983eng1422-0067Petit, Robert GironésCano, AmandaOrtiz, AlbaEspina, MartaPrat, JosefinaMuñoz, MontserratSeverino, PatríciaSouto, Eliana B.Garcia, Maria L.Pujol, MontserratSánchez-López, Elenainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-24T22:04:21Zoai:estudogeral.uc.pt:10316/104747Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:21:24.189061Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
title |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
spellingShingle |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics Petit, Robert Gironés skin inflammatory diseases psoriasis psoriasis versus atopic dermatitis biodegradable nanoparticles microneedles clinical trials Animals Clinical Trials as Topic Humans Models, Biological Nanotechnology Psoriasis Nanomedicine |
title_short |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
title_full |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
title_fullStr |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
title_full_unstemmed |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
title_sort |
Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics |
author |
Petit, Robert Gironés |
author_facet |
Petit, Robert Gironés Cano, Amanda Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Severino, Patrícia Souto, Eliana B. Garcia, Maria L. Pujol, Montserrat Sánchez-López, Elena |
author_role |
author |
author2 |
Cano, Amanda Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Severino, Patrícia Souto, Eliana B. Garcia, Maria L. Pujol, Montserrat Sánchez-López, Elena |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Petit, Robert Gironés Cano, Amanda Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Severino, Patrícia Souto, Eliana B. Garcia, Maria L. Pujol, Montserrat Sánchez-López, Elena |
dc.subject.por.fl_str_mv |
skin inflammatory diseases psoriasis psoriasis versus atopic dermatitis biodegradable nanoparticles microneedles clinical trials Animals Clinical Trials as Topic Humans Models, Biological Nanotechnology Psoriasis Nanomedicine |
topic |
skin inflammatory diseases psoriasis psoriasis versus atopic dermatitis biodegradable nanoparticles microneedles clinical trials Animals Clinical Trials as Topic Humans Models, Biological Nanotechnology Psoriasis Nanomedicine |
description |
Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/104747 http://hdl.handle.net/10316/104747 https://doi.org/10.3390/ijms22094983 |
url |
http://hdl.handle.net/10316/104747 https://doi.org/10.3390/ijms22094983 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1422-0067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI AG |
publisher.none.fl_str_mv |
MDPI AG |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134104273289216 |