The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://hdl.handle.net/1822/81321 |
Resumo: | The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy. |
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The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology modelsPTCH1-knockoutApc<sup>Min</sup>xenograftsPDXgenetically engineered mouse modelspersonalized therapytumor biologyApc(Min)Ciências Médicas::Outras Ciências MédicasScience & TechnologyThe Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.This study was funded by the Public Ministry of Labor Campinas (Research, Prevention and Education of Occupational Cancer) and by Pio XII Foundation, Barretos Cancer Hospital internal funds, Grant Number: 13/2021.Multidisciplinary Digital Publishing InstituteUniversidade do MinhoTeixeira, Silvia A.Luzzi, Mayara de CassiaMartin, Ana Carolina Baptista MorenoDuarte, Terence TeixeiraLeal, Mônica de OliveiraTeixeira, Gustavo RamosReis, Monise TadinJunior, Carlos Roberto AlmeidaSantos, KarinaMelendez, Matias EliseoSilva, Diego da Cunha Silveira Alves daBernécule, Priscila NevesFirmino, Higor Vinicius LourençoAlves, Ana Laura VieiraGuimarães, Denise PeixotoBorduqui, João VitorLaus, Ana CarolinaMançano, Bruna MinnitiReis, R. M.2022-11-162022-11-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/81321engTeixeira, S.A.; Luzzi, M.d.C.; Martin, A.C.B.M.; Duarte, T.T.; Leal, M.d.O.; Teixeira, G.R.; Reis, M.T.; Junior, C.R.A.; Santos, K.; Melendez, M.E.; Silva, D.d.C.S.A.d.; Bernécule, P.N.; Firmino, H.V.L.; Alves, A.L.V.; Guimarães, D.P.; Borduqui, J.V.; Laus, A.C.; Mançano, B.M.; Reis, R.M. The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models. Vet. Sci. 2022, 9, 636. https://doi.org/10.3390/vetsci91106362306-738110.3390/vetsci9110636https://www.mdpi.com/2306-7381/9/11/636info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:50Zoai:repositorium.sdum.uminho.pt:1822/81321Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:31.776354Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| title |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| spellingShingle |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models Teixeira, Silvia A. PTCH1-knockout Apc<sup>Min</sup> xenografts PDX genetically engineered mouse models personalized therapy tumor biology Apc(Min) Ciências Médicas::Outras Ciências Médicas Science & Technology |
| title_short |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| title_full |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| title_fullStr |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| title_full_unstemmed |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| title_sort |
The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models |
| author |
Teixeira, Silvia A. |
| author_facet |
Teixeira, Silvia A. Luzzi, Mayara de Cassia Martin, Ana Carolina Baptista Moreno Duarte, Terence Teixeira Leal, Mônica de Oliveira Teixeira, Gustavo Ramos Reis, Monise Tadin Junior, Carlos Roberto Almeida Santos, Karina Melendez, Matias Eliseo Silva, Diego da Cunha Silveira Alves da Bernécule, Priscila Neves Firmino, Higor Vinicius Lourenço Alves, Ana Laura Vieira Guimarães, Denise Peixoto Borduqui, João Vitor Laus, Ana Carolina Mançano, Bruna Minniti Reis, R. M. |
| author_role |
author |
| author2 |
Luzzi, Mayara de Cassia Martin, Ana Carolina Baptista Moreno Duarte, Terence Teixeira Leal, Mônica de Oliveira Teixeira, Gustavo Ramos Reis, Monise Tadin Junior, Carlos Roberto Almeida Santos, Karina Melendez, Matias Eliseo Silva, Diego da Cunha Silveira Alves da Bernécule, Priscila Neves Firmino, Higor Vinicius Lourenço Alves, Ana Laura Vieira Guimarães, Denise Peixoto Borduqui, João Vitor Laus, Ana Carolina Mançano, Bruna Minniti Reis, R. M. |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
Teixeira, Silvia A. Luzzi, Mayara de Cassia Martin, Ana Carolina Baptista Moreno Duarte, Terence Teixeira Leal, Mônica de Oliveira Teixeira, Gustavo Ramos Reis, Monise Tadin Junior, Carlos Roberto Almeida Santos, Karina Melendez, Matias Eliseo Silva, Diego da Cunha Silveira Alves da Bernécule, Priscila Neves Firmino, Higor Vinicius Lourenço Alves, Ana Laura Vieira Guimarães, Denise Peixoto Borduqui, João Vitor Laus, Ana Carolina Mançano, Bruna Minniti Reis, R. M. |
| dc.subject.por.fl_str_mv |
PTCH1-knockout Apc<sup>Min</sup> xenografts PDX genetically engineered mouse models personalized therapy tumor biology Apc(Min) Ciências Médicas::Outras Ciências Médicas Science & Technology |
| topic |
PTCH1-knockout Apc<sup>Min</sup> xenografts PDX genetically engineered mouse models personalized therapy tumor biology Apc(Min) Ciências Médicas::Outras Ciências Médicas Science & Technology |
| description |
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-16 2022-11-16T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/81321 |
| url |
https://hdl.handle.net/1822/81321 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Teixeira, S.A.; Luzzi, M.d.C.; Martin, A.C.B.M.; Duarte, T.T.; Leal, M.d.O.; Teixeira, G.R.; Reis, M.T.; Junior, C.R.A.; Santos, K.; Melendez, M.E.; Silva, D.d.C.S.A.d.; Bernécule, P.N.; Firmino, H.V.L.; Alves, A.L.V.; Guimarães, D.P.; Borduqui, J.V.; Laus, A.C.; Mançano, B.M.; Reis, R.M. The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models. Vet. Sci. 2022, 9, 636. https://doi.org/10.3390/vetsci9110636 2306-7381 10.3390/vetsci9110636 https://www.mdpi.com/2306-7381/9/11/636 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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