Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination

Detalhes bibliográficos
Autor(a) principal: Gonçalves, J
Data de Publicação: 2021
Outros Autores: Juliano, AM, Charepe, N, Alenquer, M, Athayde, D, Ferreira, F, Archer, M, Amorim, MJ, Serrano, F, Soares, H
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3960
Resumo: In view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and mRNA-1273 vaccines affect the immune response in lactating women and the protective profile of breastmilk. Compared with controls, lactating women had a higher frequency of circulating RBD memory B cells and higher anti-RBD antibody titers but similar neutralizing capacity. We show that upon vaccination, immune transfer to breastmilk occurs through a combination of anti-spike secretory IgA (SIgA) antibodies and spike-reactive T cells. Although we found that the concentration of anti-spike IgA in breastmilk might not be sufficient to directly neutralize SARS-CoV-2, our data suggest that cumulative transfer of IgA might provide the infant with effective neutralization capacity. Our findings put forward the possibility that breastmilk might convey both immediate (through anti-spike SIgA) and long-lived (via spike-reactive T cells) immune protection to the infant. Further studies are needed to address this possibility and to determine the functional profile of spike T cells.
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spelling Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA VaccinationMAC MED MAFAntibodies, Viral / bloodAntibodies, Viral / immunologyCOVID-19 / immunologyCOVID-19 / prevention & controlCOVID-19 Vaccines / immunology*FemaleHumansImmunity, Maternally-AcquiredImmunoglobulin A, Secretory / immunology*Lactation / immunologyMemory B Cells / immunologyMilk, Human / immunology*SARS-CoV-2 / immunology*Spike Glycoprotein, Coronavirus / immunology*T-Lymphocytes / immunology*mRNA Vaccines / immunologyVaccinationIn view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and mRNA-1273 vaccines affect the immune response in lactating women and the protective profile of breastmilk. Compared with controls, lactating women had a higher frequency of circulating RBD memory B cells and higher anti-RBD antibody titers but similar neutralizing capacity. We show that upon vaccination, immune transfer to breastmilk occurs through a combination of anti-spike secretory IgA (SIgA) antibodies and spike-reactive T cells. Although we found that the concentration of anti-spike IgA in breastmilk might not be sufficient to directly neutralize SARS-CoV-2, our data suggest that cumulative transfer of IgA might provide the infant with effective neutralization capacity. Our findings put forward the possibility that breastmilk might convey both immediate (through anti-spike SIgA) and long-lived (via spike-reactive T cells) immune protection to the infant. Further studies are needed to address this possibility and to determine the functional profile of spike T cells.ElsevierRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEGonçalves, JJuliano, AMCharepe, NAlenquer, MAthayde, DFerreira, FArcher, MAmorim, MJSerrano, FSoares, H2022-01-21T15:09:44Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3960engCell Rep Med. 2021 Dec 21;2(12):100468.10.1016/j.xcrm.2021.100468info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-28T10:29:57Zoai:repositorio.chlc.pt:10400.17/3960Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-28T10:29:57Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
title Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
spellingShingle Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
Gonçalves, J
MAC MED MAF
Antibodies, Viral / blood
Antibodies, Viral / immunology
COVID-19 / immunology
COVID-19 / prevention & control
COVID-19 Vaccines / immunology*
Female
Humans
Immunity, Maternally-Acquired
Immunoglobulin A, Secretory / immunology*
Lactation / immunology
Memory B Cells / immunology
Milk, Human / immunology*
SARS-CoV-2 / immunology*
Spike Glycoprotein, Coronavirus / immunology*
T-Lymphocytes / immunology*
mRNA Vaccines / immunology
Vaccination
title_short Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
title_full Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
title_fullStr Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
title_full_unstemmed Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
title_sort Secretory IgA and T Cells Targeting SARS-CoV-2 Spike Protein Are Transferred to the Breastmilk Upon mRNA Vaccination
author Gonçalves, J
author_facet Gonçalves, J
Juliano, AM
Charepe, N
Alenquer, M
Athayde, D
Ferreira, F
Archer, M
Amorim, MJ
Serrano, F
Soares, H
author_role author
author2 Juliano, AM
Charepe, N
Alenquer, M
Athayde, D
Ferreira, F
Archer, M
Amorim, MJ
Serrano, F
Soares, H
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Gonçalves, J
Juliano, AM
Charepe, N
Alenquer, M
Athayde, D
Ferreira, F
Archer, M
Amorim, MJ
Serrano, F
Soares, H
dc.subject.por.fl_str_mv MAC MED MAF
Antibodies, Viral / blood
Antibodies, Viral / immunology
COVID-19 / immunology
COVID-19 / prevention & control
COVID-19 Vaccines / immunology*
Female
Humans
Immunity, Maternally-Acquired
Immunoglobulin A, Secretory / immunology*
Lactation / immunology
Memory B Cells / immunology
Milk, Human / immunology*
SARS-CoV-2 / immunology*
Spike Glycoprotein, Coronavirus / immunology*
T-Lymphocytes / immunology*
mRNA Vaccines / immunology
Vaccination
topic MAC MED MAF
Antibodies, Viral / blood
Antibodies, Viral / immunology
COVID-19 / immunology
COVID-19 / prevention & control
COVID-19 Vaccines / immunology*
Female
Humans
Immunity, Maternally-Acquired
Immunoglobulin A, Secretory / immunology*
Lactation / immunology
Memory B Cells / immunology
Milk, Human / immunology*
SARS-CoV-2 / immunology*
Spike Glycoprotein, Coronavirus / immunology*
T-Lymphocytes / immunology*
mRNA Vaccines / immunology
Vaccination
description In view of the scarcity of data to guide decision making, we evaluated how BNT162b2 and mRNA-1273 vaccines affect the immune response in lactating women and the protective profile of breastmilk. Compared with controls, lactating women had a higher frequency of circulating RBD memory B cells and higher anti-RBD antibody titers but similar neutralizing capacity. We show that upon vaccination, immune transfer to breastmilk occurs through a combination of anti-spike secretory IgA (SIgA) antibodies and spike-reactive T cells. Although we found that the concentration of anti-spike IgA in breastmilk might not be sufficient to directly neutralize SARS-CoV-2, our data suggest that cumulative transfer of IgA might provide the infant with effective neutralization capacity. Our findings put forward the possibility that breastmilk might convey both immediate (through anti-spike SIgA) and long-lived (via spike-reactive T cells) immune protection to the infant. Further studies are needed to address this possibility and to determine the functional profile of spike T cells.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-01-21T15:09:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3960
url http://hdl.handle.net/10400.17/3960
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cell Rep Med. 2021 Dec 21;2(12):100468.
10.1016/j.xcrm.2021.100468
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817548655309094912

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