Human ex vivo dentin-pulp complex preservation in a full crown model

Detalhes bibliográficos
Autor(a) principal: Botelho, João
Data de Publicação: 2017
Outros Autores: Cavacas, Maria Alzira, Borrecho, Gonçalo, Polido, Mário, Oliveira, Pedro, Martins dos Santos, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/19309
Resumo: Objectives: Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth models will allow us to get closer to in vivo conditions. Thus, the aim of this study is to preserve a living dentin-pulp complex, in a novel in vitro full crown model, after tooth extraction.
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spelling Human ex vivo dentin-pulp complex preservation in a full crown modelOdontoblastsDentin-pulp complexDental pulp regenerationIn vitro full crown modelTissue engineeringObjectives: Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth models will allow us to get closer to in vivo conditions. Thus, the aim of this study is to preserve a living dentin-pulp complex, in a novel in vitro full crown model, after tooth extraction.Methods: Twenty intact third molars, after preparation, were divided into four groups, with five samples each. We placed the negative control samples (C) in saline, and the tested groups were placed (T) in supplemented DMEM, at two different times: 1 and 7 days. The specimens were processed for light microscopy observation.Results: Contrary to C-groups, T-groups showed a functional dentin-pulp complex. The treated dentin-pulp complex presents normal histological appearance.Conclusions: This study showed that it is possible to preserve a living dentin-pulp complex after tooth extraction during 7 days.ElsevierRepositório ComumBotelho, JoãoCavacas, Maria AlziraBorrecho, GonçaloPolido, MárioOliveira, PedroMartins dos Santos, José2018-01-01T01:30:09Z2017-01-01T00:00:00Z2017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/19309engJournal of Oral Biology and Craniofacial Research. Volume 7, Issue 1, January–April 2017, Pages 19-22. DOI 10.1016/j.jobcr.2016.12.0022212-426810.1016/j.jobcr.2016.12.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:57Zoai:comum.rcaap.pt:10400.26/19309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:56.785092Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Human ex vivo dentin-pulp complex preservation in a full crown model
title Human ex vivo dentin-pulp complex preservation in a full crown model
spellingShingle Human ex vivo dentin-pulp complex preservation in a full crown model
Botelho, João
Odontoblasts
Dentin-pulp complex
Dental pulp regeneration
In vitro full crown model
Tissue engineering
title_short Human ex vivo dentin-pulp complex preservation in a full crown model
title_full Human ex vivo dentin-pulp complex preservation in a full crown model
title_fullStr Human ex vivo dentin-pulp complex preservation in a full crown model
title_full_unstemmed Human ex vivo dentin-pulp complex preservation in a full crown model
title_sort Human ex vivo dentin-pulp complex preservation in a full crown model
author Botelho, João
author_facet Botelho, João
Cavacas, Maria Alzira
Borrecho, Gonçalo
Polido, Mário
Oliveira, Pedro
Martins dos Santos, José
author_role author
author2 Cavacas, Maria Alzira
Borrecho, Gonçalo
Polido, Mário
Oliveira, Pedro
Martins dos Santos, José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Botelho, João
Cavacas, Maria Alzira
Borrecho, Gonçalo
Polido, Mário
Oliveira, Pedro
Martins dos Santos, José
dc.subject.por.fl_str_mv Odontoblasts
Dentin-pulp complex
Dental pulp regeneration
In vitro full crown model
Tissue engineering
topic Odontoblasts
Dentin-pulp complex
Dental pulp regeneration
In vitro full crown model
Tissue engineering
description Objectives: Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth models will allow us to get closer to in vivo conditions. Thus, the aim of this study is to preserve a living dentin-pulp complex, in a novel in vitro full crown model, after tooth extraction.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-01T00:00:00Z
2017-01-01T00:00:00Z
2018-01-01T01:30:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/19309
url http://hdl.handle.net/10400.26/19309
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Oral Biology and Craniofacial Research. Volume 7, Issue 1, January–April 2017, Pages 19-22. DOI 10.1016/j.jobcr.2016.12.002
2212-4268
10.1016/j.jobcr.2016.12.002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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