Human ex vivo dentin-pulp complex preservation in a full crown model
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.26/19309 |
Resumo: | Objectives: Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth models will allow us to get closer to in vivo conditions. Thus, the aim of this study is to preserve a living dentin-pulp complex, in a novel in vitro full crown model, after tooth extraction. |
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Human ex vivo dentin-pulp complex preservation in a full crown modelOdontoblastsDentin-pulp complexDental pulp regenerationIn vitro full crown modelTissue engineeringObjectives: Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth models will allow us to get closer to in vivo conditions. Thus, the aim of this study is to preserve a living dentin-pulp complex, in a novel in vitro full crown model, after tooth extraction.Methods: Twenty intact third molars, after preparation, were divided into four groups, with five samples each. We placed the negative control samples (C) in saline, and the tested groups were placed (T) in supplemented DMEM, at two different times: 1 and 7 days. The specimens were processed for light microscopy observation.Results: Contrary to C-groups, T-groups showed a functional dentin-pulp complex. The treated dentin-pulp complex presents normal histological appearance.Conclusions: This study showed that it is possible to preserve a living dentin-pulp complex after tooth extraction during 7 days.ElsevierRepositório ComumBotelho, JoãoCavacas, Maria AlziraBorrecho, GonçaloPolido, MárioOliveira, PedroMartins dos Santos, José2018-01-01T01:30:09Z2017-01-01T00:00:00Z2017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/19309engJournal of Oral Biology and Craniofacial Research. Volume 7, Issue 1, January–April 2017, Pages 19-22. DOI 10.1016/j.jobcr.2016.12.0022212-426810.1016/j.jobcr.2016.12.002info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:52:57Zoai:comum.rcaap.pt:10400.26/19309Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:08:56.785092Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Human ex vivo dentin-pulp complex preservation in a full crown model |
title |
Human ex vivo dentin-pulp complex preservation in a full crown model |
spellingShingle |
Human ex vivo dentin-pulp complex preservation in a full crown model Botelho, João Odontoblasts Dentin-pulp complex Dental pulp regeneration In vitro full crown model Tissue engineering |
title_short |
Human ex vivo dentin-pulp complex preservation in a full crown model |
title_full |
Human ex vivo dentin-pulp complex preservation in a full crown model |
title_fullStr |
Human ex vivo dentin-pulp complex preservation in a full crown model |
title_full_unstemmed |
Human ex vivo dentin-pulp complex preservation in a full crown model |
title_sort |
Human ex vivo dentin-pulp complex preservation in a full crown model |
author |
Botelho, João |
author_facet |
Botelho, João Cavacas, Maria Alzira Borrecho, Gonçalo Polido, Mário Oliveira, Pedro Martins dos Santos, José |
author_role |
author |
author2 |
Cavacas, Maria Alzira Borrecho, Gonçalo Polido, Mário Oliveira, Pedro Martins dos Santos, José |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Comum |
dc.contributor.author.fl_str_mv |
Botelho, João Cavacas, Maria Alzira Borrecho, Gonçalo Polido, Mário Oliveira, Pedro Martins dos Santos, José |
dc.subject.por.fl_str_mv |
Odontoblasts Dentin-pulp complex Dental pulp regeneration In vitro full crown model Tissue engineering |
topic |
Odontoblasts Dentin-pulp complex Dental pulp regeneration In vitro full crown model Tissue engineering |
description |
Objectives: Currently, there is lack of human in vitro full tooth models that hold the odontoblast layer with pulp tissue in their native environment. The appearance of new in vitro and in vivo models has provided new understanding of the potential of tissue engineering in dental pulp regeneration. However, the development of new in vitro full tooth models will allow us to get closer to in vivo conditions. Thus, the aim of this study is to preserve a living dentin-pulp complex, in a novel in vitro full crown model, after tooth extraction. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01T00:00:00Z 2017-01-01T00:00:00Z 2018-01-01T01:30:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/19309 |
url |
http://hdl.handle.net/10400.26/19309 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Oral Biology and Craniofacial Research. Volume 7, Issue 1, January–April 2017, Pages 19-22. DOI 10.1016/j.jobcr.2016.12.002 2212-4268 10.1016/j.jobcr.2016.12.002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799129958272991232 |