MERS coronavirus: an emerging zoonotic virus

Detalhes bibliográficos
Autor(a) principal: Li, Fang
Data de Publicação: 2019
Outros Autores: Du, Lanying
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/39405
Resumo: Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that was first reported in humans in June 2012 [1]. To date, MERS-CoV continues to infect humans with a fatality rate of ~35%. At least 27 countries have reported human infections with MERS-CoV (https://www.who.int/emergencies/mers-cov/en/). MERS-CoV is a zoonotic virus. Like severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV is believed to have originated from bats [2,3]. However, whereas the bat-to-human transmission of SARS-CoV was likely mediated by palm civets as intermediate hosts, humans likely acquired MERS-CoV from dromedary camels [4,5,6]. Human-to-human transmission of MERS-CoV does occur, but it is limited mostly to health care environments [7,8]. Moreover, whereas SARS-CoV recognizes angiotensin-converting enzyme 2 (ACE2) as a cellular receptor [9,10], MERS-CoV uses dipeptidyl peptidase 4 (DPP4) to enter target cells [11,12]. Currently, no vaccines or antiviral therapeutics have been approved for the prevention or treatment of MERS-CoV infection, although a number of them have been developed preclinically and/or tested clinically [13,14,15,16].
id UFLA_4c6f693fa16deaad5eb1f4f93b5ae216
oai_identifier_str oai:localhost:1/39405
network_acronym_str UFLA
network_name_str Repositório Institucional da UFLA
repository_id_str
spelling MERS coronavirus: an emerging zoonotic virusCoronavirusZoonotic virusSevere Acute Respiratory Syndrome (SARS)Vírus zoonóticoSíndrome respiratória aguda graveMiddle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that was first reported in humans in June 2012 [1]. To date, MERS-CoV continues to infect humans with a fatality rate of ~35%. At least 27 countries have reported human infections with MERS-CoV (https://www.who.int/emergencies/mers-cov/en/). MERS-CoV is a zoonotic virus. Like severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV is believed to have originated from bats [2,3]. However, whereas the bat-to-human transmission of SARS-CoV was likely mediated by palm civets as intermediate hosts, humans likely acquired MERS-CoV from dromedary camels [4,5,6]. Human-to-human transmission of MERS-CoV does occur, but it is limited mostly to health care environments [7,8]. Moreover, whereas SARS-CoV recognizes angiotensin-converting enzyme 2 (ACE2) as a cellular receptor [9,10], MERS-CoV uses dipeptidyl peptidase 4 (DPP4) to enter target cells [11,12]. Currently, no vaccines or antiviral therapeutics have been approved for the prevention or treatment of MERS-CoV infection, although a number of them have been developed preclinically and/or tested clinically [13,14,15,16].MDPI2020-03-25T19:29:19Z2020-03-25T19:29:19Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLI, F.; DU, L. MERS coronavirus: an emerging zoonotic virus. Viruses, [S. l.], v. 11, n. 7, 2019. DOI: https://doi.org/10.3390/v11070663.http://repositorio.ufla.br/jspui/handle/1/39405Virusesreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessLi, FangDu, Lanyingeng2020-06-26T12:31:45Zoai:localhost:1/39405Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2020-06-26T12:31:45Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv MERS coronavirus: an emerging zoonotic virus
title MERS coronavirus: an emerging zoonotic virus
spellingShingle MERS coronavirus: an emerging zoonotic virus
Li, Fang
Coronavirus
Zoonotic virus
Severe Acute Respiratory Syndrome (SARS)
Vírus zoonótico
Síndrome respiratória aguda grave
title_short MERS coronavirus: an emerging zoonotic virus
title_full MERS coronavirus: an emerging zoonotic virus
title_fullStr MERS coronavirus: an emerging zoonotic virus
title_full_unstemmed MERS coronavirus: an emerging zoonotic virus
title_sort MERS coronavirus: an emerging zoonotic virus
author Li, Fang
author_facet Li, Fang
Du, Lanying
author_role author
author2 Du, Lanying
author2_role author
dc.contributor.author.fl_str_mv Li, Fang
Du, Lanying
dc.subject.por.fl_str_mv Coronavirus
Zoonotic virus
Severe Acute Respiratory Syndrome (SARS)
Vírus zoonótico
Síndrome respiratória aguda grave
topic Coronavirus
Zoonotic virus
Severe Acute Respiratory Syndrome (SARS)
Vírus zoonótico
Síndrome respiratória aguda grave
description Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that was first reported in humans in June 2012 [1]. To date, MERS-CoV continues to infect humans with a fatality rate of ~35%. At least 27 countries have reported human infections with MERS-CoV (https://www.who.int/emergencies/mers-cov/en/). MERS-CoV is a zoonotic virus. Like severe acute respiratory syndrome coronavirus (SARS-CoV), MERS-CoV is believed to have originated from bats [2,3]. However, whereas the bat-to-human transmission of SARS-CoV was likely mediated by palm civets as intermediate hosts, humans likely acquired MERS-CoV from dromedary camels [4,5,6]. Human-to-human transmission of MERS-CoV does occur, but it is limited mostly to health care environments [7,8]. Moreover, whereas SARS-CoV recognizes angiotensin-converting enzyme 2 (ACE2) as a cellular receptor [9,10], MERS-CoV uses dipeptidyl peptidase 4 (DPP4) to enter target cells [11,12]. Currently, no vaccines or antiviral therapeutics have been approved for the prevention or treatment of MERS-CoV infection, although a number of them have been developed preclinically and/or tested clinically [13,14,15,16].
publishDate 2019
dc.date.none.fl_str_mv 2019
2020-03-25T19:29:19Z
2020-03-25T19:29:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv LI, F.; DU, L. MERS coronavirus: an emerging zoonotic virus. Viruses, [S. l.], v. 11, n. 7, 2019. DOI: https://doi.org/10.3390/v11070663.
http://repositorio.ufla.br/jspui/handle/1/39405
identifier_str_mv LI, F.; DU, L. MERS coronavirus: an emerging zoonotic virus. Viruses, [S. l.], v. 11, n. 7, 2019. DOI: https://doi.org/10.3390/v11070663.
url http://repositorio.ufla.br/jspui/handle/1/39405
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Viruses
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
_version_ 1815439370213130240