Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases

Detalhes bibliográficos
Autor(a) principal: Valdoleiros, Sofia R.
Data de Publicação: 2021
Outros Autores: Furtado, Isabel, Silva, Carolina, Correia Gonçalves, Inês, Santos Silva, André, Vasconcelos, Olga, Aboim Horta, Ana, Vasconcelos, A. Ludgero, Xará, Sandra, Gonçalves, Maria João, Araújo Abreu, Miguel, Sarmento-Castro, Rui
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625
Resumo: We propose a guideline about the risk, prevention and treatment of infection in the patient under immunomodulatory or immunosuppressive therapy in the context of autoimmune or autoinflammatory disease. It is divided into three sections: drugs and associated risk of infection; immunizations; risk, prevention, and treatment of specific infections. The treatment of autoimmune diseases involves the use of immunosuppressive or immunomodulatory therapies, with an increasing number of new drugs being used. It is associated with an increased risk of infection, which may be present globally or only for specific agents, varying widely depending on the pharmacological class and even within the same class. The prevention strategy and clinical management need to be individually tailored and there are several key factors: characterization of the disease that prompts the immunosuppression, understanding of the mechanism of action of the immunosuppressive drug, knowledge of previous infections, recognition of risk factors, laboratory test results, vaccine administration, monitoring of clinical signs and symptoms and patient education.
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spelling Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune DiseasesProtocolo de Prevenção e Tratamento de Infeções Associadas à Terapêutica Imunossupressora de Doenças AutoimunesAutoimmune Diseases/drug therapyImmunosuppressive AgentsInfections/drug therapyInfections/prevention & controlVaccine-Preventable DiseasesDoenças Autoimunes/terapêutica farmacológicaDoenças Preveníveis por VacinaImunossupressoresInfeções/prevenção & controloInfeções/terapêutica farmacológicaWe propose a guideline about the risk, prevention and treatment of infection in the patient under immunomodulatory or immunosuppressive therapy in the context of autoimmune or autoinflammatory disease. It is divided into three sections: drugs and associated risk of infection; immunizations; risk, prevention, and treatment of specific infections. The treatment of autoimmune diseases involves the use of immunosuppressive or immunomodulatory therapies, with an increasing number of new drugs being used. It is associated with an increased risk of infection, which may be present globally or only for specific agents, varying widely depending on the pharmacological class and even within the same class. The prevention strategy and clinical management need to be individually tailored and there are several key factors: characterization of the disease that prompts the immunosuppression, understanding of the mechanism of action of the immunosuppressive drug, knowledge of previous infections, recognition of risk factors, laboratory test results, vaccine administration, monitoring of clinical signs and symptoms and patient education.O presente protocolo aborda o risco, prevenção e tratamento da infeção no doente sob terapêutica imunomoduladora ou imunossupressora em contexto de doença autoimune ou autoinflamatória. Subdivide-se nas seguintes secções: fármacos e risco associado de infeção; imunizações; risco, prevenção e tratamento de infeções específicas. Com um número crescente de novos fármacos em utilização nos últimos anos, o tratamento de doenças autoimunes envolve a utilização de terapêuticas imunossupressoras ou imunomoduladoras e associa-se a aumento do risco de infeção, que pode estar presente de uma forma global ou apenas para infeções por agentes específicos, variando amplamente consoante a classe farmacológica e mesmo dentro desta. Na estruturação da estratégia preventiva são fundamentais a caracterização da patologia que motiva a imunossupressão, a compreensão do mecanismo de ação do imunossupressor, a aferição de infeções prévias, o reconhecimento de fatores de risco, a realização de rastreios laboratoriais, a administração de vacinas, a educação do doente e a monitorização de sintomas e sinais clínicos, na dependência de uma gestão clínica necessariamente individualizada.Ordem dos Médicos2021-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625oai:ojs.www.actamedicaportuguesa.com:article/15625Acta Médica Portuguesa; Vol. 34 No. 6 (2021): June; 469-483Acta Médica Portuguesa; Vol. 34 N.º 6 (2021): Junho; 469-4831646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625/6351https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625/6352Direitos de Autor (c) 2021 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessValdoleiros, Sofia R.Furtado, IsabelSilva, CarolinaCorreia Gonçalves, InêsSantos Silva, AndréVasconcelos, OlgaAboim Horta, AnaVasconcelos, A. LudgeroXará, SandraGonçalves, Maria JoãoAraújo Abreu, MiguelSarmento-Castro, Rui2022-12-20T11:07:35Zoai:ojs.www.actamedicaportuguesa.com:article/15625Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:20:39.777902Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
Protocolo de Prevenção e Tratamento de Infeções Associadas à Terapêutica Imunossupressora de Doenças Autoimunes
title Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
spellingShingle Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
Valdoleiros, Sofia R.
Autoimmune Diseases/drug therapy
Immunosuppressive Agents
Infections/drug therapy
Infections/prevention & control
Vaccine-Preventable Diseases
Doenças Autoimunes/terapêutica farmacológica
Doenças Preveníveis por Vacina
Imunossupressores
Infeções/prevenção & controlo
Infeções/terapêutica farmacológica
title_short Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
title_full Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
title_fullStr Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
title_full_unstemmed Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
title_sort Guideline for the Treatment and Prevention of Infections Associated with Immunosuppressive Therapy for Autoimmune Diseases
author Valdoleiros, Sofia R.
author_facet Valdoleiros, Sofia R.
Furtado, Isabel
Silva, Carolina
Correia Gonçalves, Inês
Santos Silva, André
Vasconcelos, Olga
Aboim Horta, Ana
Vasconcelos, A. Ludgero
Xará, Sandra
Gonçalves, Maria João
Araújo Abreu, Miguel
Sarmento-Castro, Rui
author_role author
author2 Furtado, Isabel
Silva, Carolina
Correia Gonçalves, Inês
Santos Silva, André
Vasconcelos, Olga
Aboim Horta, Ana
Vasconcelos, A. Ludgero
Xará, Sandra
Gonçalves, Maria João
Araújo Abreu, Miguel
Sarmento-Castro, Rui
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Valdoleiros, Sofia R.
Furtado, Isabel
Silva, Carolina
Correia Gonçalves, Inês
Santos Silva, André
Vasconcelos, Olga
Aboim Horta, Ana
Vasconcelos, A. Ludgero
Xará, Sandra
Gonçalves, Maria João
Araújo Abreu, Miguel
Sarmento-Castro, Rui
dc.subject.por.fl_str_mv Autoimmune Diseases/drug therapy
Immunosuppressive Agents
Infections/drug therapy
Infections/prevention & control
Vaccine-Preventable Diseases
Doenças Autoimunes/terapêutica farmacológica
Doenças Preveníveis por Vacina
Imunossupressores
Infeções/prevenção & controlo
Infeções/terapêutica farmacológica
topic Autoimmune Diseases/drug therapy
Immunosuppressive Agents
Infections/drug therapy
Infections/prevention & control
Vaccine-Preventable Diseases
Doenças Autoimunes/terapêutica farmacológica
Doenças Preveníveis por Vacina
Imunossupressores
Infeções/prevenção & controlo
Infeções/terapêutica farmacológica
description We propose a guideline about the risk, prevention and treatment of infection in the patient under immunomodulatory or immunosuppressive therapy in the context of autoimmune or autoinflammatory disease. It is divided into three sections: drugs and associated risk of infection; immunizations; risk, prevention, and treatment of specific infections. The treatment of autoimmune diseases involves the use of immunosuppressive or immunomodulatory therapies, with an increasing number of new drugs being used. It is associated with an increased risk of infection, which may be present globally or only for specific agents, varying widely depending on the pharmacological class and even within the same class. The prevention strategy and clinical management need to be individually tailored and there are several key factors: characterization of the disease that prompts the immunosuppression, understanding of the mechanism of action of the immunosuppressive drug, knowledge of previous infections, recognition of risk factors, laboratory test results, vaccine administration, monitoring of clinical signs and symptoms and patient education.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-01
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dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625/6351
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/15625/6352
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2021 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos de Autor (c) 2021 Acta Médica Portuguesa
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 34 No. 6 (2021): June; 469-483
Acta Médica Portuguesa; Vol. 34 N.º 6 (2021): Junho; 469-483
1646-0758
0870-399X
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