Plasma aminothiol profile and some of its determinants in apparently Azorean subjects

Detalhes bibliográficos
Autor(a) principal: Lima, Ana
Data de Publicação: 2014
Outros Autores: Ferin, Rita, Baptista, José, Pavão, Maria Leonor
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/2816
Resumo: Copyright © 2014 Ana Lima et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Plasma aminothiol profile and some of its determinants in apparently Azorean subjectsAtherosclerosisPlasma Aminothiol Profile (PAP)Copyright © 2014 Ana Lima et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.OBJECTIVES. To evaluate the plasma aminothiol profile (PAP) and serumgamma-glutamyltransferase (GGT) activity, aswell as plasma folate, vitamin B12, and vitamin B6 concentrations, in 326 apparently healthy subjects from the Azores archipelago (Portugal). Also eventual relationships of PAP with conventional risk factors for atherosclerosis were investigated, aiming at the finding of early blood markers of the disease. DESIGN AND METHODS.This was an observational cross-sectional study, where participants were split into two groups: one with a normal and another with an altered PAP (at least one aminothiol out of its reference concentration range). RESULTS. About 76% of subjects had an altered PAP, mainly due to low glutathione levels (<1.5 μmol/L), mostly associated with normal GGT activity. Prevalence of hyperhomocysteinemia was 10%, where only 33% had some B-vitamin deficiency. The risk for atherosclerosis wasmore evidenced in subjects exhibiting both deficient GSH concentration and increased serum GGT activity. CONCLUSIONS. An altered PAP, namely, when caused by low GSH levels in the absence of alterations in the Hcy, or Cys, or Cys-Gly concentrations and in serum GGT activity, might reveal a subclinical stage of atherogenesis and should be explored as a potential early marker of atherosclerosis.Governo Regional dos Açores.Hindawi Publishing CorporationRepositório da Universidade dos AçoresLima, AnaFerin, RitaBaptista, JoséPavão, Maria Leonor2014-02-21T18:23:13Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/2816engLima. A., Ferin, R., Baptista, J. e Pavão, M.L. (2014). "Plasma aminothiol profile and some of its determinants in apparently Azorean subjects". ISRN Oxidative Medicine, Vol. 2014, Article ID 961013, 9 pages. http://dx.doi.org/10.1155/2014/961013.2314-6400 (Online)info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:30:40Zoai:repositorio.uac.pt:10400.3/2816Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:25:27.477697Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
title Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
spellingShingle Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
Lima, Ana
Atherosclerosis
Plasma Aminothiol Profile (PAP)
title_short Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
title_full Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
title_fullStr Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
title_full_unstemmed Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
title_sort Plasma aminothiol profile and some of its determinants in apparently Azorean subjects
author Lima, Ana
author_facet Lima, Ana
Ferin, Rita
Baptista, José
Pavão, Maria Leonor
author_role author
author2 Ferin, Rita
Baptista, José
Pavão, Maria Leonor
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Lima, Ana
Ferin, Rita
Baptista, José
Pavão, Maria Leonor
dc.subject.por.fl_str_mv Atherosclerosis
Plasma Aminothiol Profile (PAP)
topic Atherosclerosis
Plasma Aminothiol Profile (PAP)
description Copyright © 2014 Ana Lima et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-21T18:23:13Z
2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/2816
url http://hdl.handle.net/10400.3/2816
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lima. A., Ferin, R., Baptista, J. e Pavão, M.L. (2014). "Plasma aminothiol profile and some of its determinants in apparently Azorean subjects". ISRN Oxidative Medicine, Vol. 2014, Article ID 961013, 9 pages. http://dx.doi.org/10.1155/2014/961013.
2314-6400 (Online)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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