The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review

Detalhes bibliográficos
Autor(a) principal: Gouveia, Maria
Data de Publicação: 2018
Outros Autores: Sanches, Raquel, Andrade, Sara, Carmona, Sara, Ferreira, Carolina
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277
Resumo: Introduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.Material and Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms ‘testosterone’, ‘androgens’, ‘libido’, ‘sexual dysfunctions’ and ‘menopause’.Results: From a pool of 506 articles, 11 were selected: three guidelines, one systematic review with meta-analysis and seven randomized controlled trials. The selected articles showed testosterone‘s efficacy on global sexual function and improvement of sexual desire in postmenopausal women, when both are used in monotherapy or in association with other hormones. No study showed changes in hepatic enzymes or serious adverse effects.Discussion: The small sample size and short follow-up used in the included studies limits the ability to assess testosterone’s long-term benefits and effects.Conclusion: At short-term, testosterone seems to improve sexual function in postmenopausal women, particularly sexual desire. Nevertheless, more studies with larger sample size and longer follow-up are needed to understand its long-term safety and effectiveness.
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spelling The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical ReviewO Papel da Testosterona na Melhoria do Desejo Sexual da Mulher Pós-Menopáusica: Uma Revisão Baseada na EvidênciaAndrogensLibidoPostmenopauseSexual DysfunctionsPsychological/drug therapyTestosteroneAndrogéniosDisfunções Sexuais Psicogénicas/tratamentoLibidoPós-MenopausaTestosteronaIntroduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.Material and Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms ‘testosterone’, ‘androgens’, ‘libido’, ‘sexual dysfunctions’ and ‘menopause’.Results: From a pool of 506 articles, 11 were selected: three guidelines, one systematic review with meta-analysis and seven randomized controlled trials. The selected articles showed testosterone‘s efficacy on global sexual function and improvement of sexual desire in postmenopausal women, when both are used in monotherapy or in association with other hormones. No study showed changes in hepatic enzymes or serious adverse effects.Discussion: The small sample size and short follow-up used in the included studies limits the ability to assess testosterone’s long-term benefits and effects.Conclusion: At short-term, testosterone seems to improve sexual function in postmenopausal women, particularly sexual desire. Nevertheless, more studies with larger sample size and longer follow-up are needed to understand its long-term safety and effectiveness.Introdução: A disfunção sexual feminina é um problema comum que atinge mais de 1/3 das mulheres em alguma fase da vida. O objetivo deste trabalho é rever a evidência existente acerca da eficácia da testosterona na disfunção sexual, em particular na melhoria do desejo, em mulheres pós-menopáusicas.Material e Métodos: Pesquisa nas bases de dados National Guidelines Clearinghouse, Guidelines Finder, The Cochrane Library e MEDLINE/PubMed, de normas de orientação clínica, revisões sistemáticas, meta-análises e ensaios clínicos aleatorizados e controlados, publicados entre janeiro de 2005 e fevereiro de 2017, utilizando os termos MeSH ‘testosterone’, ‘androgens’, ‘libido’, ‘sexualdysfunctions’ e ‘menopause’.Resultados: Foram incluídos 11 artigos de uma pesquisa inicial de 506: três normas de orientação clínica, uma revisão sistemática com meta-análise e sete ensaios clínicos aleatorizados e controlados. Os artigos selecionados mostraram eficácia da terapêutica com testosterona, em monoterapia ou em associação com outras hormonas, na melhoria global da função sexual e na melhoria do desejo sexual em mulheres na pós-menopausa. Nenhum dos estudos evidenciou alterações das enzimas hepáticas ou efeitos adversos graves.Discussão: Os estudos incluídos tinham amostras de pequenas dimensões e período de follow-up curto, o que impossibilitou a avaliação dos efeitos a longo prazo do tratamento com testosterona.Conclusão: A terapêutica com testosterona tem benefício, a curto prazo, na melhoria das queixas de disfunção sexual em mulheres pós-menopáusicas, em particular na melhoria do desejo. Contudo, são necessários estudos com amostras de maior dimensão e período de follow-up mais longo, de modo a avaliar a sua efetividade e segurança a longo prazo.Ordem dos Médicos2018-11-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfimage/jpegapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfapplication/mswordapplication/mswordapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277oai:ojs.www.actamedicaportuguesa.com:article/9277Acta Médica Portuguesa; Vol. 31 No. 11 (2018): November; 680-690Acta Médica Portuguesa; Vol. 31 N.º 11 (2018): Novembro; 680-6901646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/5538https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/9403https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/9404https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/9409https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/10083https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/10383https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/10749Direitos de Autor (c) 2018 Acta Médica Portuguesainfo:eu-repo/semantics/openAccessGouveia, MariaSanches, RaquelAndrade, SaraCarmona, SaraFerreira, Carolina2022-12-20T11:05:43Zoai:ojs.www.actamedicaportuguesa.com:article/9277Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:19:41.960768Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
O Papel da Testosterona na Melhoria do Desejo Sexual da Mulher Pós-Menopáusica: Uma Revisão Baseada na Evidência
title The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
spellingShingle The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
Gouveia, Maria
Androgens
Libido
Postmenopause
Sexual Dysfunctions
Psychological/drug therapy
Testosterone
Androgénios
Disfunções Sexuais Psicogénicas/tratamento
Libido
Pós-Menopausa
Testosterona
title_short The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
title_full The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
title_fullStr The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
title_full_unstemmed The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
title_sort The Role of Testosterone in The Improvement of Sexual Desire in Postmenopausal Women: An Evidence-Based Clinical Review
author Gouveia, Maria
author_facet Gouveia, Maria
Sanches, Raquel
Andrade, Sara
Carmona, Sara
Ferreira, Carolina
author_role author
author2 Sanches, Raquel
Andrade, Sara
Carmona, Sara
Ferreira, Carolina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gouveia, Maria
Sanches, Raquel
Andrade, Sara
Carmona, Sara
Ferreira, Carolina
dc.subject.por.fl_str_mv Androgens
Libido
Postmenopause
Sexual Dysfunctions
Psychological/drug therapy
Testosterone
Androgénios
Disfunções Sexuais Psicogénicas/tratamento
Libido
Pós-Menopausa
Testosterona
topic Androgens
Libido
Postmenopause
Sexual Dysfunctions
Psychological/drug therapy
Testosterone
Androgénios
Disfunções Sexuais Psicogénicas/tratamento
Libido
Pós-Menopausa
Testosterona
description Introduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.Material and Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms ‘testosterone’, ‘androgens’, ‘libido’, ‘sexual dysfunctions’ and ‘menopause’.Results: From a pool of 506 articles, 11 were selected: three guidelines, one systematic review with meta-analysis and seven randomized controlled trials. The selected articles showed testosterone‘s efficacy on global sexual function and improvement of sexual desire in postmenopausal women, when both are used in monotherapy or in association with other hormones. No study showed changes in hepatic enzymes or serious adverse effects.Discussion: The small sample size and short follow-up used in the included studies limits the ability to assess testosterone’s long-term benefits and effects.Conclusion: At short-term, testosterone seems to improve sexual function in postmenopausal women, particularly sexual desire. Nevertheless, more studies with larger sample size and longer follow-up are needed to understand its long-term safety and effectiveness.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-30
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/10083
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/10383
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/9277/10749
dc.rights.driver.fl_str_mv Direitos de Autor (c) 2018 Acta Médica Portuguesa
info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 31 No. 11 (2018): November; 680-690
Acta Médica Portuguesa; Vol. 31 N.º 11 (2018): Novembro; 680-690
1646-0758
0870-399X
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