Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/47260 |
Resumo: | © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
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Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementiaFrontotemporal dementia (FTD)Functional magnetic resonance imaging (fMRI)Network connectivityPresymptomatic© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Introduction: The presymptomatic phase of neurodegenerative disease can last many years, with sustained cognitive function despite progressive atrophy. We investigate this phenomenon in familial frontotemporal dementia (FTD). Methods: We studied 121 presymptomatic FTD mutation carriers and 134 family members without mutations, using multivariate data-driven approach to link cognitive performance with both structural and functional magnetic resonance imaging. Atrophy and brain network connectivity were compared between groups, in relation to the time from expected symptom onset. Results: There were group differences in brain structure and function, in the absence of differences in cognitive performance. Specifically, we identified behaviorally relevant structural and functional network differences. Structure-function relationships were similar in both groups, but coupling between functional connectivity and cognition was stronger for carriers than for non-carriers, and increased with proximity to the expected onset of disease. Discussion: Our findings suggest that the maintenance of functional network connectivity enables carriers to maintain cognitive performance.K.A.T. is supported by the British Academy Postdoctoral Fellowship (PF160048) and the Guarantors of Brain (101149). J.B.R. is supported by the Wellcome Trust (103838), the Medical Research Council (SUAG/051 G101400), and the Cambridge NIHR Biomedical Research Centre. R. S.‐V. is supported by the Instituto de Salud Carlos III and the JPND network PreFrontAls (01ED1512/AC14/0013) and the Fundació Marató de TV3 (20143810). M.M and E.F are supported by the UK Medical Research Council, the Italian Ministry of Health, and the Canadian Institutes of Health Research as part of a Centres of Excellence in Neurodegeneration grant, and also a Canadian Institutes of Health Research operating grant (MOP 327387) and funding from the Weston Brain Institute. J.D.R., D.C., and K.M.M. are supported by the NIHR Queen Square Dementia Biomedical Research Unit, the NIHR UCL/H Biomedical Research Centre, and the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility. J.D.R. is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH), the MRC UK GENFI grant (MR/ M023664/1), and The Bluefield Project. F.T. is supported by the Italian Ministry of Health (Grant NET‐2011‐02346784). L.C.J. and J.V.S. are supported by the Association for Frontotemporal Dementias Research Grant 2009, ZonMw Memorabel project number 733050103 and 733050813, and the Bluefield project. R.G. is supported by Italian Ministry of Health, Ricerca Corrente. J.L. was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145; SyNergy ‐ ID 390857198). The Swedish contributors C.G., L.O., and C.A. were supported by grants from JPND Prefrontals Swedish Research Council (VR) 529‐2014‐7504, JPND GENFI‐PROX Swedish Research Council (VR) 2019‐02248, Swedish Research Council (VR) 2015‐ 02926, Swedish Research Council (VR) 2018‐02754, Swedish FTD Initiative‐Schorling Foundation, Swedish Brain Foundation, Swedish Alzheimer Foundation, Stockholm County Council ALF, Karolinska Institutet Doctoral Funding, and StratNeuro, Swedish Demensfonden, during the conduct of the study.John Wiley & Sons, Inc.Repositório da Universidade de LisboaTsvetanov, Kamen A.Gazzina, StefanoJones, P. SimonSwieten, JohnBorroni, BarbaraSanchez‐Valle, RaquelMoreno, FerminLaforce, RobertGraff, CarolineSynofzik, MatthisGalimberti, DanielaMoore, Katrina MDuro, DianaFenoglio, ChiaraFerrari, CamillaFerreira, CarlosFerreira, Catarina B.Flanagan, TobyFox, NickFreedman, MorrisFumagalli, GiorgioPanman, JessicaGabilondo, AlazneGasparotti, RobertoGauthier, SergeGazzina, StefanoGiaccone, GiorgioGorostidi, AnaGreaves, CarolineGuerreiro, RitaHeller, CarolinHoegen, TobiasPapma, JanneIndakoetxea, BegoñaJelic, VesnaJiskoot, LizeKarnath, Hans‐OttoInstitutet, KarolinskaKeren, RonLangheinrich, TobiasLeitão, Maria JoãoLladó, AlbertLombardi, GemmaPiaceri, IreneLoosli, SandraMaruta, CarolinaMead, SimonMeeter, LiekeMiltenberger-Miltenyi, Gabrielvan Minkelen, RickMitchell, SaraNacmias, BenedettaNeason, MollieNicholas, JenniferPievani, MichelaOlives, JaumePadovani, AlessandroPijnenburg, YolandePolito, CristinaPremi, EnricoPrioni, SaraPrix, CatharinaRademakers, RosaMasellis, MarioRedaelli, VeronicaRittman, TimRogaeva, EkaterinaRosa‐Neto, PedroRossi, GiacominaRossor, MartinSantiago, BeatrizScarpini, ElioSchönecker, SonjaSemler, ElisaTartaglia, Maria CarmelaShafei, RachelleShoesmith, ChristenTábuas‐Pereira, MiguelTainta, MikelTaipa, RicardoTang‐Wai, DavidThomas, David LThompson, PaulThonberg, HakanTimberlake, CarolynFinger, ElizabethTiraboschi, PietroVandamme, PhilipVandenbulcke, MathieuVeldsman, MicheleVerdelho, AnaVillanua, JorgeWarren, JasonWilke, CarloWoollacott, IoneWlasich, ElisabethVandenberghe, RikZetterberg, HenrikZulaica, MirenDe Mendonça, AlexandreTagliavini, FabrizioSantana, IsabelDucharme, SimonButler, ChrisGerhard, AlexanderDanek, AdrianLevin, JohannesOtto, MarkusFrisoni, GiovanniGhidoni, RobertaSorbi, SandroRohrer, Jonathan D.Rowe, James B.Afonso, SóniaAlmeida, Maria RosarioAnderl‐Straub, SarahAndersson, ChristinAntonell, AnnaArchetti, SilvanaArighi, AndreaBalasa, MirceaBarandiaran, MyriamBargalló, NuriaBartha, RobartBender, BenjaminBenussi, LuisaBessi, ValentinaBinetti, GiulianoBlack, SandraBocchetta, MartinaBorrego‐Ecija, SergiBras, JoseBruffaerts, RoseCaroppo, PaolaCash, DavidCastelo-Branco, MiguelConvery, RhianCope, ThomasCosseddu, Maurade Arriba, MaríaDi Fede, GiuseppeDíaz, Zigor2021-04-06T16:59:34Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47260engAlzheimers Dement. 2021 Mar;17(3):500-5141552-526010.1002/alz.122091552-5279info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:03Zoai:repositorio.ul.pt:10451/47260Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:20.587234Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
title |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
spellingShingle |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia Tsvetanov, Kamen A. Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
title_short |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
title_full |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
title_fullStr |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
title_full_unstemmed |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
title_sort |
Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia |
author |
Tsvetanov, Kamen A. |
author_facet |
Tsvetanov, Kamen A. Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
author_role |
author |
author2 |
Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Tsvetanov, Kamen A. Gazzina, Stefano Jones, P. Simon Swieten, John Borroni, Barbara Sanchez‐Valle, Raquel Moreno, Fermin Laforce, Robert Graff, Caroline Synofzik, Matthis Galimberti, Daniela Moore, Katrina M Duro, Diana Fenoglio, Chiara Ferrari, Camilla Ferreira, Carlos Ferreira, Catarina B. Flanagan, Toby Fox, Nick Freedman, Morris Fumagalli, Giorgio Panman, Jessica Gabilondo, Alazne Gasparotti, Roberto Gauthier, Serge Gazzina, Stefano Giaccone, Giorgio Gorostidi, Ana Greaves, Caroline Guerreiro, Rita Heller, Carolin Hoegen, Tobias Papma, Janne Indakoetxea, Begoña Jelic, Vesna Jiskoot, Lize Karnath, Hans‐Otto Institutet, Karolinska Keren, Ron Langheinrich, Tobias Leitão, Maria João Lladó, Albert Lombardi, Gemma Piaceri, Irene Loosli, Sandra Maruta, Carolina Mead, Simon Meeter, Lieke Miltenberger-Miltenyi, Gabriel van Minkelen, Rick Mitchell, Sara Nacmias, Benedetta Neason, Mollie Nicholas, Jennifer Pievani, Michela Olives, Jaume Padovani, Alessandro Pijnenburg, Yolande Polito, Cristina Premi, Enrico Prioni, Sara Prix, Catharina Rademakers, Rosa Masellis, Mario Redaelli, Veronica Rittman, Tim Rogaeva, Ekaterina Rosa‐Neto, Pedro Rossi, Giacomina Rossor, Martin Santiago, Beatriz Scarpini, Elio Schönecker, Sonja Semler, Elisa Tartaglia, Maria Carmela Shafei, Rachelle Shoesmith, Christen Tábuas‐Pereira, Miguel Tainta, Mikel Taipa, Ricardo Tang‐Wai, David Thomas, David L Thompson, Paul Thonberg, Hakan Timberlake, Carolyn Finger, Elizabeth Tiraboschi, Pietro Vandamme, Philip Vandenbulcke, Mathieu Veldsman, Michele Verdelho, Ana Villanua, Jorge Warren, Jason Wilke, Carlo Woollacott, Ione Wlasich, Elisabeth Vandenberghe, Rik Zetterberg, Henrik Zulaica, Miren De Mendonça, Alexandre Tagliavini, Fabrizio Santana, Isabel Ducharme, Simon Butler, Chris Gerhard, Alexander Danek, Adrian Levin, Johannes Otto, Markus Frisoni, Giovanni Ghidoni, Roberta Sorbi, Sandro Rohrer, Jonathan D. Rowe, James B. Afonso, Sónia Almeida, Maria Rosario Anderl‐Straub, Sarah Andersson, Christin Antonell, Anna Archetti, Silvana Arighi, Andrea Balasa, Mircea Barandiaran, Myriam Bargalló, Nuria Bartha, Robart Bender, Benjamin Benussi, Luisa Bessi, Valentina Binetti, Giuliano Black, Sandra Bocchetta, Martina Borrego‐Ecija, Sergi Bras, Jose Bruffaerts, Rose Caroppo, Paola Cash, David Castelo-Branco, Miguel Convery, Rhian Cope, Thomas Cosseddu, Maura de Arriba, María Di Fede, Giuseppe Díaz, Zigor |
dc.subject.por.fl_str_mv |
Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
topic |
Frontotemporal dementia (FTD) Functional magnetic resonance imaging (fMRI) Network connectivity Presymptomatic |
description |
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-04-06T16:59:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/47260 |
url |
http://hdl.handle.net/10451/47260 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Alzheimers Dement. 2021 Mar;17(3):500-514 1552-5260 10.1002/alz.12209 1552-5279 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
publisher.none.fl_str_mv |
John Wiley & Sons, Inc. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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