Case Report
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/158271 |
Resumo: | Funding Information: This work is financed by national funds through the FCT - Foundation for Science and Technology, I.P., under the project UIDB/04585/2020. Publisher Copyright: 2023 Simão Raimundo, Cordeiro, Parente Freixo, Valente Pinto, Neves and Farela Neves. |
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Case ReportPatient with deficiency of ADA2 presenting leukocytoclastic vasculitis and pericarditis during infliximab treatmentadenosine deaminase 2 (ADA2)anti-TNF-αDADA2infliximableukocytoclastic vasculitispericarditisPediatrics, Perinatology, and Child HealthFunding Information: This work is financed by national funds through the FCT - Foundation for Science and Technology, I.P., under the project UIDB/04585/2020. Publisher Copyright: 2023 Simão Raimundo, Cordeiro, Parente Freixo, Valente Pinto, Neves and Farela Neves.Deficiency of adenosine deaminase 2 (DADA2), first reported in 2014, is a disease with great phenotypic variability, which has been increasingly reported. Therapeutic response depends on the phenotype. We present a case of an adolescent with recurrent fever, oral aphthous ulcers, and lymphadenopathy from 8 to 12 years of age and subsequently presented with symptomatic neutropenia. After the diagnosis of DADA2, therapy with infliximab was started, but after the second dose, she developed leukocytoclastic vasculitis and showed symptoms of myopericarditis. Infliximab was switched to etanercept, with no relapses. Despite the safety of tumor necrosis factor alpha inhibitors (TNFi), paradoxical adverse effects have been increasingly reported. The differential diagnosis between disease new-onset manifestations of DADA2 and side effects of TNFi can be challenging and warrants further clarification.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSimão Raimundo, DianaCordeiro, Ana IsabelParente Freixo, JoãoValente Pinto, MartaNeves, ConceiçãoFarela Neves, João2023-09-25T22:20:09Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158271eng2296-2360PURE: 72194641https://doi.org/10.3389/fped.2023.1200401info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:40:33Zoai:run.unl.pt:10362/158271Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:02.877572Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Case Report Patient with deficiency of ADA2 presenting leukocytoclastic vasculitis and pericarditis during infliximab treatment |
| title |
Case Report |
| spellingShingle |
Case Report Simão Raimundo, Diana adenosine deaminase 2 (ADA2) anti-TNF-α DADA2 infliximab leukocytoclastic vasculitis pericarditis Pediatrics, Perinatology, and Child Health |
| title_short |
Case Report |
| title_full |
Case Report |
| title_fullStr |
Case Report |
| title_full_unstemmed |
Case Report |
| title_sort |
Case Report |
| author |
Simão Raimundo, Diana |
| author_facet |
Simão Raimundo, Diana Cordeiro, Ana Isabel Parente Freixo, João Valente Pinto, Marta Neves, Conceição Farela Neves, João |
| author_role |
author |
| author2 |
Cordeiro, Ana Isabel Parente Freixo, João Valente Pinto, Marta Neves, Conceição Farela Neves, João |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Simão Raimundo, Diana Cordeiro, Ana Isabel Parente Freixo, João Valente Pinto, Marta Neves, Conceição Farela Neves, João |
| dc.subject.por.fl_str_mv |
adenosine deaminase 2 (ADA2) anti-TNF-α DADA2 infliximab leukocytoclastic vasculitis pericarditis Pediatrics, Perinatology, and Child Health |
| topic |
adenosine deaminase 2 (ADA2) anti-TNF-α DADA2 infliximab leukocytoclastic vasculitis pericarditis Pediatrics, Perinatology, and Child Health |
| description |
Funding Information: This work is financed by national funds through the FCT - Foundation for Science and Technology, I.P., under the project UIDB/04585/2020. Publisher Copyright: 2023 Simão Raimundo, Cordeiro, Parente Freixo, Valente Pinto, Neves and Farela Neves. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-25T22:20:09Z 2023-06 2023-06-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/158271 |
| url |
http://hdl.handle.net/10362/158271 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2296-2360 PURE: 72194641 https://doi.org/10.3389/fped.2023.1200401 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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