Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10284/8258 |
Resumo: | The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers. |
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Fluorimetric and solubility studies of nadolol and atenolol in SDS micellesb-blockersSDS micellesSpectrofluorimetrySolubilityBinding constantsThe effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers.ElsevierRepositório Institucional da Universidade Fernando Pessoade Castro, BaltazarGameiro, PaulaGuimarães, CarlaLima, José L.F.CReis, Salette2019-11-27T12:55:21Z1998-01-01T00:00:00Z1998-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10284/8258eng0731-708510.1016/S0731-7085(98)00211-8metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-06T02:07:39Zoai:bdigital.ufp.pt:10284/8258Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:45:10.090015Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
title |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
spellingShingle |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles de Castro, Baltazar b-blockers SDS micelles Spectrofluorimetry Solubility Binding constants |
title_short |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
title_full |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
title_fullStr |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
title_full_unstemmed |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
title_sort |
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles |
author |
de Castro, Baltazar |
author_facet |
de Castro, Baltazar Gameiro, Paula Guimarães, Carla Lima, José L.F.C Reis, Salette |
author_role |
author |
author2 |
Gameiro, Paula Guimarães, Carla Lima, José L.F.C Reis, Salette |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Institucional da Universidade Fernando Pessoa |
dc.contributor.author.fl_str_mv |
de Castro, Baltazar Gameiro, Paula Guimarães, Carla Lima, José L.F.C Reis, Salette |
dc.subject.por.fl_str_mv |
b-blockers SDS micelles Spectrofluorimetry Solubility Binding constants |
topic |
b-blockers SDS micelles Spectrofluorimetry Solubility Binding constants |
description |
The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two b-blockers (atenolol and nadolol) were studied at 25.090.1°C and I=0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the b-blockers. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-01-01T00:00:00Z 1998-01-01T00:00:00Z 2019-11-27T12:55:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10284/8258 |
url |
http://hdl.handle.net/10284/8258 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0731-7085 10.1016/S0731-7085(98)00211-8 |
dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
metadata only access |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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