Thiamine deficiency in Gambian women of reproductive age

Detalhes bibliográficos
Autor(a) principal: Bourassa, Megan W.
Data de Publicação: 2022
Outros Autores: Gomes, Filomena, Jones, Kerry S., Koulman, Albert, Prentice, Andrew M., Cerami, Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/133485
Resumo: Funding Information: This research was funded by a grant from the Bill & Melinda Gates Foundation to the New York Academy of Sciences. We would like to thank Damon Parkington, Amanda McKillion, and Taba-sum Tabasum, who performed the ETKac measurements. K.S.J. and A.K. are supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (IS-BRC-1215-20014). The NIHR Cambridge Biomedical Research Centre is a partnership between Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, funded by the NIHR. The views expressed are those of the authors and not necessarily those of the NHS, NIHR, or UK Department of Health and Social Care.
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spelling Thiamine deficiency in Gambian women of reproductive ageNeuroscience(all)Biochemistry, Genetics and Molecular Biology(all)History and Philosophy of ScienceFunding Information: This research was funded by a grant from the Bill & Melinda Gates Foundation to the New York Academy of Sciences. We would like to thank Damon Parkington, Amanda McKillion, and Taba-sum Tabasum, who performed the ETKac measurements. K.S.J. and A.K. are supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (IS-BRC-1215-20014). The NIHR Cambridge Biomedical Research Centre is a partnership between Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, funded by the NIHR. The views expressed are those of the authors and not necessarily those of the NHS, NIHR, or UK Department of Health and Social Care.Thiamine deficiency disorders are associated with a variety of clinical symptoms affecting the nervous and cardiovascular systems. There is growing recognition that thiamine deficiency can occur in populations well beyond the classical region of South Asia, and at-risk populations include those who receive a large proportion of their energy from polished white rice (or other low-thiamine staple foods) and with low dietary diversity. Reports of thiamine deficiency in West Africa over the last century have suggested that this has historically been an issue in this population, but in more recent decades, these reports have been limited to prison populations. To understand if thiamine deficiency might be an unrecognized problem in the communities of this region, erythrocyte samples collected during the wet and dry seasons from 226 women of reproductive age (mean age = 28 years old) were assessed for thiamine status by measuring the erythrocyte transketolase activity coefficient (ETKac). Overall, 35.8% of the sample was at high risk of thiamine deficiency (ETKac ≥ 1.25). Risk of thiamine deficiency was significantly higher in the wet (47.9%) compared with the dry season (22.9%) (P < 0.001). To our knowledge, this is the first report of biochemical thiamine deficiency in a free-living population in West Africa in the 21st century and suggests that further investigation is warranted.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBourassa, Megan W.Gomes, FilomenaJones, Kerry S.Koulman, AlbertPrentice, Andrew M.Cerami, Carla2022-02-23T23:17:40Z2022-012022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/133485eng0077-8923PURE: 41736415https://doi.org/10.1111/nyas.14695info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:12:05Zoai:run.unl.pt:10362/133485Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:48.728370Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Thiamine deficiency in Gambian women of reproductive age
title Thiamine deficiency in Gambian women of reproductive age
spellingShingle Thiamine deficiency in Gambian women of reproductive age
Bourassa, Megan W.
Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science
title_short Thiamine deficiency in Gambian women of reproductive age
title_full Thiamine deficiency in Gambian women of reproductive age
title_fullStr Thiamine deficiency in Gambian women of reproductive age
title_full_unstemmed Thiamine deficiency in Gambian women of reproductive age
title_sort Thiamine deficiency in Gambian women of reproductive age
author Bourassa, Megan W.
author_facet Bourassa, Megan W.
Gomes, Filomena
Jones, Kerry S.
Koulman, Albert
Prentice, Andrew M.
Cerami, Carla
author_role author
author2 Gomes, Filomena
Jones, Kerry S.
Koulman, Albert
Prentice, Andrew M.
Cerami, Carla
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Bourassa, Megan W.
Gomes, Filomena
Jones, Kerry S.
Koulman, Albert
Prentice, Andrew M.
Cerami, Carla
dc.subject.por.fl_str_mv Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science
topic Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science
description Funding Information: This research was funded by a grant from the Bill & Melinda Gates Foundation to the New York Academy of Sciences. We would like to thank Damon Parkington, Amanda McKillion, and Taba-sum Tabasum, who performed the ETKac measurements. K.S.J. and A.K. are supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (IS-BRC-1215-20014). The NIHR Cambridge Biomedical Research Centre is a partnership between Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, funded by the NIHR. The views expressed are those of the authors and not necessarily those of the NHS, NIHR, or UK Department of Health and Social Care.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-23T23:17:40Z
2022-01
2022-01-01T00:00:00Z
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/133485
url http://hdl.handle.net/10362/133485
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language eng
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PURE: 41736415
https://doi.org/10.1111/nyas.14695
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