A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation

Detalhes bibliográficos
Autor(a) principal: Dias, André
Data de Publicação: 2020
Outros Autores: Lozovska, Anastasiia, Wymeersch, Filip J., Nóvoa, Ana, Binagui-Casas, Anahi, Sobral, Daniel, Martins, Gabriel G., Wilson, Valerie, Mallo, Moises
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/120727
Resumo: LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806
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spelling A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongationNeuroscience(all)Biochemistry, Genetics and Molecular Biology(all)Immunology and Microbiology(all)LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806Formation of the vertebrate postcranial body axis follows two sequential but distinct phases. The first phase generates pre-sacral structures (the so-called primary body) through the activity of the primitive streak on axial progenitors within the epiblast. The embryo then switches to generate the secondary body (post-sacral structures), which depends on axial progenitors in the tail bud. Here we show that the mammalian tail bud is generated through an independent functional developmental module, concurrent but functionally different from that generating the primary body. This module is triggered by convergent Tgfbr1 and Snai1 activities that promote an incomplete epithelial to mesenchymal transition on a subset of epiblast axial progenitors. This EMT is functionally different from that coordinated by the primitive streak, as it does not lead to mesodermal differentiation but brings axial progenitors into a transitory state, keeping their progenitor activity to drive further axial body extension.DCV - Departamento de Ciências da VidaUCIBIO - Applied Molecular Biosciences UnitRUNDias, AndréLozovska, AnastasiiaWymeersch, Filip J.Nóvoa, AnaBinagui-Casas, AnahiSobral, DanielMartins, Gabriel G.Wilson, ValerieMallo, Moises2021-07-08T22:19:30Z2020-062020-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article28application/pdfhttp://hdl.handle.net/10362/120727eng2050-084XPURE: 32427018https://doi.org/10.7554/eLife.56615info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:11Zoai:run.unl.pt:10362/120727Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:25.793998Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
spellingShingle A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
Dias, André
Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
title_short A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_full A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_fullStr A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_full_unstemmed A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
title_sort A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation
author Dias, André
author_facet Dias, André
Lozovska, Anastasiia
Wymeersch, Filip J.
Nóvoa, Ana
Binagui-Casas, Anahi
Sobral, Daniel
Martins, Gabriel G.
Wilson, Valerie
Mallo, Moises
author_role author
author2 Lozovska, Anastasiia
Wymeersch, Filip J.
Nóvoa, Ana
Binagui-Casas, Anahi
Sobral, Daniel
Martins, Gabriel G.
Wilson, Valerie
Mallo, Moises
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DCV - Departamento de Ciências da Vida
UCIBIO - Applied Molecular Biosciences Unit
RUN
dc.contributor.author.fl_str_mv Dias, André
Lozovska, Anastasiia
Wymeersch, Filip J.
Nóvoa, Ana
Binagui-Casas, Anahi
Sobral, Daniel
Martins, Gabriel G.
Wilson, Valerie
Mallo, Moises
dc.subject.por.fl_str_mv Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
topic Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
description LISBOA-01?0145-FEDER-030254 SCML-MC-60-2014 LISBOA-01-0145-FEDER-022170 PD/BD/128426/2017 PD/BD/128437/2017 MR/S008799/1 MR/ K011200/1 DEV-170806
publishDate 2020
dc.date.none.fl_str_mv 2020-06
2020-06-01T00:00:00Z
2021-07-08T22:19:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120727
url http://hdl.handle.net/10362/120727
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2050-084X
PURE: 32427018
https://doi.org/10.7554/eLife.56615
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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