“Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana
Data de Publicação: 2020
Outros Autores: Bessa, Lucinda J., Correia, Patrícia, Fernandes, Iva, Ferraz, Ricardo, Gameiro, Paula, Teixeira, Cátia, Gomes, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/16530
Resumo: A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
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spelling “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stabilityAntibacterialAntibiofilmIonic liquidMultidrug resistancePeptideSkin infectionsTyrosinaseWound healingA covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.MDPIRepositório Científico do Instituto Politécnico do PortoGomes, AnaBessa, Lucinda J.Correia, PatríciaFernandes, IvaFerraz, RicardoGameiro, PaulaTeixeira, CátiaGomes, Paula2020-12-04T12:22:02Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/16530engGomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/617410.3390/ijms21176174info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:03:41Zoai:recipp.ipp.pt:10400.22/16530Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:36:11.125843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
title “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
spellingShingle “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
Gomes, Ana
Antibacterial
Antibiofilm
Ionic liquid
Multidrug resistance
Peptide
Skin infections
Tyrosinase
Wound healing
title_short “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
title_full “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
title_fullStr “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
title_full_unstemmed “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
title_sort “Clicking” an ionic liquid to a potent antimicrobial peptide: on the route towards improved stability
author Gomes, Ana
author_facet Gomes, Ana
Bessa, Lucinda J.
Correia, Patrícia
Fernandes, Iva
Ferraz, Ricardo
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
author_role author
author2 Bessa, Lucinda J.
Correia, Patrícia
Fernandes, Iva
Ferraz, Ricardo
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Gomes, Ana
Bessa, Lucinda J.
Correia, Patrícia
Fernandes, Iva
Ferraz, Ricardo
Gameiro, Paula
Teixeira, Cátia
Gomes, Paula
dc.subject.por.fl_str_mv Antibacterial
Antibiofilm
Ionic liquid
Multidrug resistance
Peptide
Skin infections
Tyrosinase
Wound healing
topic Antibacterial
Antibiofilm
Ionic liquid
Multidrug resistance
Peptide
Skin infections
Tyrosinase
Wound healing
description A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-04T12:22:02Z
2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/16530
url http://hdl.handle.net/10400.22/16530
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes, A., Bessa, L. J., Correia, P., Fernandes, I., Ferraz, R., Gameiro, P., Teixeira, C., & Gomes, P. (2020). “Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability. International Journal of Molecular Sciences, 21(17), 6174. https://www.mdpi.com/1422-0067/21/17/6174
10.3390/ijms21176174
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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