EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study

Detalhes bibliográficos
Autor(a) principal: Sousa, Vítor
Data de Publicação: 2015
Outros Autores: Espírito Santo, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/30436
https://doi.org/10.1007/s00428-011-1062-5
Resumo: Trabalho final do 6º médico com vista à atribuição do grau de mestre a Joana Espírito Santo apresentado à Faculdade de Medicina da Universidade de Coimbra
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spelling EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic studyNeoplasias do pulmãoTransformação celular neoplásicaEpitélioEGFRHER2/c-erB-2CK7LP34Trabalho final do 6º médico com vista à atribuição do grau de mestre a Joana Espírito Santo apresentado à Faculdade de Medicina da Universidade de CoimbraAn interpretative diagnosis of preneoplastic lesions would have impact in lung cancer early diagnosis and survival together with the study of Erb-B family receptors as they have an important role in lung carcinogenesis. The existence of tirosine kinase inhibitors stresses the 2 importance of studding gene alterations with possible defined implications in patients’ selection for chemoprevention schemes and characterization of carcinogenesis. This study concerns bronchial preneoplastic lesions observed in biopsies as basal cell hyperplasia, squamous metaplasia and dysplasia. Using immunohistochemistry, those lesions were characterized by antibodies applied against LP34 (high weigh molecular cytokeratin), CK7, Chromogranin A, Ki67, p53, C-erbB-2 and EGFR. HER2 and EGFR gene copy number was also evaluated by fluorescent in situ hybridization (FISH) in those lesions. The expected results defined the origin cell for adaptative and preneoplastic lesions. By known experiences and published data, beyond the stem cell, the spectral evolution of bronchial preneoplastic lesions was demonstrated by characterizing basal cells (LP34) and their neoplastic potentiality. Dysplasias showed a higher expression of EGFR, Ki67 and p53 with a stepwise increase with the gravity of the preneoplastic lesions. C-erbB-2 immunohistochemical overexpression is a rare event in preneoplastic lesions. Polyssomy was the main mechanism for EGFR and HER2/neu high gene copy number. HER2 and EGFR will be expected to understand early carcinogenesis as well as increased proliferation index (Ki67).2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/30436http://hdl.handle.net/10316/30436https://doi.org/10.1007/s00428-011-1062-5engSousa, VítorEspírito Santo, Joanainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-11-06T16:48:40Zoai:estudogeral.uc.pt:10316/30436Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:44:21.388533Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
title EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
spellingShingle EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
Sousa, Vítor
Neoplasias do pulmão
Transformação celular neoplásica
Epitélio
EGFR
HER2/c-erB-2
CK7
LP34
title_short EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
title_full EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
title_fullStr EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
title_full_unstemmed EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
title_sort EGFR/erB-1, HER2/erB-2, CK7 and LP34 expression in preneoplastic lesions of respiratory epithelium: an immunohistochemical and genetic study
author Sousa, Vítor
author_facet Sousa, Vítor
Espírito Santo, Joana
author_role author
author2 Espírito Santo, Joana
author2_role author
dc.contributor.author.fl_str_mv Sousa, Vítor
Espírito Santo, Joana
dc.subject.por.fl_str_mv Neoplasias do pulmão
Transformação celular neoplásica
Epitélio
EGFR
HER2/c-erB-2
CK7
LP34
topic Neoplasias do pulmão
Transformação celular neoplásica
Epitélio
EGFR
HER2/c-erB-2
CK7
LP34
description Trabalho final do 6º médico com vista à atribuição do grau de mestre a Joana Espírito Santo apresentado à Faculdade de Medicina da Universidade de Coimbra
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/30436
http://hdl.handle.net/10316/30436
https://doi.org/10.1007/s00428-011-1062-5
url http://hdl.handle.net/10316/30436
https://doi.org/10.1007/s00428-011-1062-5
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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