Bacteriophages as a diagnostic tool for early Alzheimer's disease

Detalhes bibliográficos
Autor(a) principal: Martins, Ivone M.
Data de Publicação: 2019
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/77006
Resumo: Invited Lecture.
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spelling Bacteriophages as a diagnostic tool for early Alzheimer's diseaseInvited Lecture.Alzheimers disease is an irreversible, progressive and age-dependent neurodegenerative disorder affecting millions of people worldwide. Amyloid-beta (AB) is a prime suspect to cause Alzheimers disease (AD). An accumulation of AB in the brain leads to its aggregation into soluble oligomeric and fibrillar clusters. In AD-mouse models, these AB oligomers and fibrils impair synaptic function and memory formation. A diagnostic tool to detect AB oligomers/fibrils selectively in the brain is currently not available. Specific amyloidogenic motifs were described to react with AB fibrils and oligomers however, the blood-brain-barrier (BBB) is a major bottleneck for effective brain applications. To overcome this limitation, bacteriophages (phages) and phage display technology represent an interesting tool as delivery vehicles able to shuttle its cargo across the BBB. In this seminar an overview of a project, aiming at developing a cost-effective and safe phage-based tool to selectively diagnose AB oligomers and fibrils during the early stage of AD, as well as some promising results, will be presented.info:eu-repo/semantics/publishedVersionUniversidade do MinhoMartins, Ivone M.2019-07-052019-07-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectapplication/pdfhttp://hdl.handle.net/1822/77006engMartins, Ivone M., Invited Lecture: Bacteriophages as a diagnostic tool for early Alzheimer's disease. iMed ULisboa Seminar, Lisboa, Portugal, 2019.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:27:17Zoai:repositorium.sdum.uminho.pt:1822/77006Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:21:50.388852Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Bacteriophages as a diagnostic tool for early Alzheimer's disease
title Bacteriophages as a diagnostic tool for early Alzheimer's disease
spellingShingle Bacteriophages as a diagnostic tool for early Alzheimer's disease
Martins, Ivone M.
title_short Bacteriophages as a diagnostic tool for early Alzheimer's disease
title_full Bacteriophages as a diagnostic tool for early Alzheimer's disease
title_fullStr Bacteriophages as a diagnostic tool for early Alzheimer's disease
title_full_unstemmed Bacteriophages as a diagnostic tool for early Alzheimer's disease
title_sort Bacteriophages as a diagnostic tool for early Alzheimer's disease
author Martins, Ivone M.
author_facet Martins, Ivone M.
author_role author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Martins, Ivone M.
description Invited Lecture.
publishDate 2019
dc.date.none.fl_str_mv 2019-07-05
2019-07-05T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/77006
url http://hdl.handle.net/1822/77006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, Ivone M., Invited Lecture: Bacteriophages as a diagnostic tool for early Alzheimer's disease. iMed ULisboa Seminar, Lisboa, Portugal, 2019.
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eu_rights_str_mv openAccess
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