Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation

Detalhes bibliográficos
Autor(a) principal: Ferreira, Mónica
Data de Publicação: 2023
Outros Autores: Laranjo, Sergio, Cunha, Pedro, Geraldes, Vera, Oliveira, Mario, Rocha, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/59887
Resumo: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillationAtrial fibrillationAutonomic functionBaroreceptor reflexBaroreflex effectiveness indexBaroreflex gain© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).The abnormal neural control of atria has been considered one of the mechanisms of paroxysmal atrial fibrillation (PAF) pathogenesis. The baroreceptor reflex has an important role in cardiovascular regulation and may serve as an index of autonomic function. This study aimed to analyze the baroreceptor reflex's role in heart rate regulation during upright tilt (HUT) in patients with lone PAF. The study included 68 patients with lone PAF and 34 healthy individuals who underwent baroreflex assessment. Parameters such as baroreflex sensitivity (BRS), number of systolic blood pressure (BP) ramps, and the baroreflex effectiveness index (BEI) were evaluated. The study found that PAF patients had comparable resting BPs and heart rates (HRs) to healthy individuals. However, unlike healthy individuals, PAF patients showed a sustained increase in BP with an upright posture followed by the delayed activation of the baroreceptor function with a blunted HR response and lower BEI values. This indicates a pronounced baroreflex impairment in PAF patients, even at rest. Our data suggest that together with BRS, BEI could be used as a marker of autonomic dysfunction in PAF patients, making it important to further investigate its relationship with AF recurrence after ablation and its involvement in cardiovascular autonomic remodeling.MDPIRepositório da Universidade de LisboaFerreira, MónicaLaranjo, SergioCunha, PedroGeraldes, VeraOliveira, MarioRocha, Isabel2023-10-18T14:27:45Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59887engJ Clin Med. 2023 Sep 8;12(18):585710.3390/jcm121858572077-0383info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:08:57Zoai:repositorio.ul.pt:10451/59887Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:09:34.231363Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
title Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
spellingShingle Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
Ferreira, Mónica
Atrial fibrillation
Autonomic function
Baroreceptor reflex
Baroreflex effectiveness index
Baroreflex gain
title_short Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
title_full Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
title_fullStr Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
title_full_unstemmed Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
title_sort Orthostatic stress and baroreflex sensitivity: a window into autonomic dysfunction in lone paroxysmal atrial fibrillation
author Ferreira, Mónica
author_facet Ferreira, Mónica
Laranjo, Sergio
Cunha, Pedro
Geraldes, Vera
Oliveira, Mario
Rocha, Isabel
author_role author
author2 Laranjo, Sergio
Cunha, Pedro
Geraldes, Vera
Oliveira, Mario
Rocha, Isabel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Ferreira, Mónica
Laranjo, Sergio
Cunha, Pedro
Geraldes, Vera
Oliveira, Mario
Rocha, Isabel
dc.subject.por.fl_str_mv Atrial fibrillation
Autonomic function
Baroreceptor reflex
Baroreflex effectiveness index
Baroreflex gain
topic Atrial fibrillation
Autonomic function
Baroreceptor reflex
Baroreflex effectiveness index
Baroreflex gain
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-10-18T14:27:45Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/59887
url http://hdl.handle.net/10451/59887
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Med. 2023 Sep 8;12(18):5857
10.3390/jcm12185857
2077-0383
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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