Orthostatic Stress and Baroreflex Sensitivity

Detalhes bibliográficos
Autor(a) principal: Ferreira, Mónica
Data de Publicação: 2023
Outros Autores: Laranjo, Sergio, Cunha, Pedro, Geraldes, Vera, Oliveira, Mário, Rocha, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158792
Resumo: Publisher Copyright: © 2023 by the authors.
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spelling Orthostatic Stress and Baroreflex SensitivityA Window into Autonomic Dysfunction in Lone Paroxysmal Atrial Fibrillationatrial fibrillationautonomic functionbaroreceptor reflexbaroreflex effectiveness indexbaroreflex gainMedicine(all)Publisher Copyright: © 2023 by the authors.The abnormal neural control of atria has been considered one of the mechanisms of paroxysmal atrial fibrillation (PAF) pathogenesis. The baroreceptor reflex has an important role in cardiovascular regulation and may serve as an index of autonomic function. This study aimed to analyze the baroreceptor reflex’s role in heart rate regulation during upright tilt (HUT) in patients with lone PAF. The study included 68 patients with lone PAF and 34 healthy individuals who underwent baroreflex assessment. Parameters such as baroreflex sensitivity (BRS), number of systolic blood pressure (BP) ramps, and the baroreflex effectiveness index (BEI) were evaluated. The study found that PAF patients had comparable resting BPs and heart rates (HRs) to healthy individuals. However, unlike healthy individuals, PAF patients showed a sustained increase in BP with an upright posture followed by the delayed activation of the baroreceptor function with a blunted HR response and lower BEI values. This indicates a pronounced baroreflex impairment in PAF patients, even at rest. Our data suggest that together with BRS, BEI could be used as a marker of autonomic dysfunction in PAF patients, making it important to further investigate its relationship with AF recurrence after ablation and its involvement in cardiovascular autonomic remodeling.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNFerreira, MónicaLaranjo, SergioCunha, PedroGeraldes, VeraOliveira, MárioRocha, Isabel2023-10-09T22:18:33Z2023-092023-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/158792eng2077-0383PURE: 73492033https://doi.org/10.3390/jcm12185857info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:41:17Zoai:run.unl.pt:10362/158792Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:17.730827Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Orthostatic Stress and Baroreflex Sensitivity
A Window into Autonomic Dysfunction in Lone Paroxysmal Atrial Fibrillation
title Orthostatic Stress and Baroreflex Sensitivity
spellingShingle Orthostatic Stress and Baroreflex Sensitivity
Ferreira, Mónica
atrial fibrillation
autonomic function
baroreceptor reflex
baroreflex effectiveness index
baroreflex gain
Medicine(all)
title_short Orthostatic Stress and Baroreflex Sensitivity
title_full Orthostatic Stress and Baroreflex Sensitivity
title_fullStr Orthostatic Stress and Baroreflex Sensitivity
title_full_unstemmed Orthostatic Stress and Baroreflex Sensitivity
title_sort Orthostatic Stress and Baroreflex Sensitivity
author Ferreira, Mónica
author_facet Ferreira, Mónica
Laranjo, Sergio
Cunha, Pedro
Geraldes, Vera
Oliveira, Mário
Rocha, Isabel
author_role author
author2 Laranjo, Sergio
Cunha, Pedro
Geraldes, Vera
Oliveira, Mário
Rocha, Isabel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Ferreira, Mónica
Laranjo, Sergio
Cunha, Pedro
Geraldes, Vera
Oliveira, Mário
Rocha, Isabel
dc.subject.por.fl_str_mv atrial fibrillation
autonomic function
baroreceptor reflex
baroreflex effectiveness index
baroreflex gain
Medicine(all)
topic atrial fibrillation
autonomic function
baroreceptor reflex
baroreflex effectiveness index
baroreflex gain
Medicine(all)
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-09T22:18:33Z
2023-09
2023-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158792
url http://hdl.handle.net/10362/158792
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2077-0383
PURE: 73492033
https://doi.org/10.3390/jcm12185857
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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