Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/11665 |
Resumo: | Williams syndrome (WS), a neurodevelopmental genetic disorder due to a microdeletion in chromosome 7, is described as displaying an intriguing socio-cognitive phenotype. Deficits in prosody production and comprehension have been consistently reported in behavioral studies. It remains, however, to be clarified the neurobiological processes underlying prosody processing in WS. This study aimed at characterizing the electrophysiological response to neutral, happy, and angry prosody in WS, and examining if this response was dependent on the semantic content of the utterance. A group of 12 participants (5 female and 7male), diagnosed with WS, with age range between 9 and 31 years, was compared with a group of typically developing participants, individually matched for chronological age, gender and laterality. After inspection of EEG artifacts, data from 9 participants with WS and 10 controls were included in ERP analyses. Participants were presented with neutral, positive and negative sentences, in two conditions: (1) with intelligible semantic and syntactic information; (2) with unintelligible semantic and syntactic information (‘pure prosody’ condition). They were asked to decide which emotion was underlying the auditory sentence. Atypical event-related potentials (ERP) components were related with prosodic processing (N100, P200, N300) in WS. In particular, reduced N100 was observed for prosody sentences with semantic content; more positive P200 for sentences with semantic content, in particular for happy and angry intonations; and reduced N300 for both types of sentence conditions. These findings suggest abnormalities in early auditory processing, indicating a bottomup contribution to the impairment in emotional prosody processing and comprehension. Also, at least for N100 and P200, they suggest the top-down contributions of semantic processes in the sensory processing of speech. This study showed, for the first time, that abnormalities in ERP measures of early auditory processing in WS are also present during the processing of emotional vocal information. This may represent a physiological signature of underlying impaired on-line language and socio-emotional processing. |
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Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials studyWilliams syndromeEvent-related potentialsEmotional prosodySemanticsNeurodevelopmentSocial SciencesScience & TechnologyWilliams syndrome (WS), a neurodevelopmental genetic disorder due to a microdeletion in chromosome 7, is described as displaying an intriguing socio-cognitive phenotype. Deficits in prosody production and comprehension have been consistently reported in behavioral studies. It remains, however, to be clarified the neurobiological processes underlying prosody processing in WS. This study aimed at characterizing the electrophysiological response to neutral, happy, and angry prosody in WS, and examining if this response was dependent on the semantic content of the utterance. A group of 12 participants (5 female and 7male), diagnosed with WS, with age range between 9 and 31 years, was compared with a group of typically developing participants, individually matched for chronological age, gender and laterality. After inspection of EEG artifacts, data from 9 participants with WS and 10 controls were included in ERP analyses. Participants were presented with neutral, positive and negative sentences, in two conditions: (1) with intelligible semantic and syntactic information; (2) with unintelligible semantic and syntactic information (‘pure prosody’ condition). They were asked to decide which emotion was underlying the auditory sentence. Atypical event-related potentials (ERP) components were related with prosodic processing (N100, P200, N300) in WS. In particular, reduced N100 was observed for prosody sentences with semantic content; more positive P200 for sentences with semantic content, in particular for happy and angry intonations; and reduced N300 for both types of sentence conditions. These findings suggest abnormalities in early auditory processing, indicating a bottomup contribution to the impairment in emotional prosody processing and comprehension. Also, at least for N100 and P200, they suggest the top-down contributions of semantic processes in the sensory processing of speech. This study showed, for the first time, that abnormalities in ERP measures of early auditory processing in WS are also present during the processing of emotional vocal information. This may represent a physiological signature of underlying impaired on-line language and socio-emotional processing.This work was supported by a Doctoral Grant (SFRH/BD/35882/2007) awarded to APP, as well as by the grant PIC/IC/83290/2007Fundação para a Ciência e a Tecnologia (FCT)ElsevierUniversidade do MinhoPinheiro, Ana P.Galdo-Álvarez, SantiagoRauber, Andréia SchurtSampaio, AdrianaNiznikiewicz, MargaretGonçalves, Óscar F.20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/11665engPinheiro, A. P., Galdo-Álvarez, S., Rauber, A., Sampaio, A., Niznikiewicz, M., & Gonçalves, Ó. F. (2011). Abnormal processing of emotional prosody in Williams syndrome: An event-related potentials study. Research in Developmental Disabilities, 32(1), 133-147. doi: https://doi.org/10.1016/j.ridd.2010.09.0110891-422210.1016/j.ridd.2010.09.01120961731info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:53:07Zoai:repositorium.sdum.uminho.pt:1822/11665Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:53:07Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
title |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
spellingShingle |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study Pinheiro, Ana P. Williams syndrome Event-related potentials Emotional prosody Semantics Neurodevelopment Social Sciences Science & Technology |
title_short |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
title_full |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
title_fullStr |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
title_full_unstemmed |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
title_sort |
Abnormal processing of emotional prosody in Williams syndrome: an event-related potentials study |
author |
Pinheiro, Ana P. |
author_facet |
Pinheiro, Ana P. Galdo-Álvarez, Santiago Rauber, Andréia Schurt Sampaio, Adriana Niznikiewicz, Margaret Gonçalves, Óscar F. |
author_role |
author |
author2 |
Galdo-Álvarez, Santiago Rauber, Andréia Schurt Sampaio, Adriana Niznikiewicz, Margaret Gonçalves, Óscar F. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pinheiro, Ana P. Galdo-Álvarez, Santiago Rauber, Andréia Schurt Sampaio, Adriana Niznikiewicz, Margaret Gonçalves, Óscar F. |
dc.subject.por.fl_str_mv |
Williams syndrome Event-related potentials Emotional prosody Semantics Neurodevelopment Social Sciences Science & Technology |
topic |
Williams syndrome Event-related potentials Emotional prosody Semantics Neurodevelopment Social Sciences Science & Technology |
description |
Williams syndrome (WS), a neurodevelopmental genetic disorder due to a microdeletion in chromosome 7, is described as displaying an intriguing socio-cognitive phenotype. Deficits in prosody production and comprehension have been consistently reported in behavioral studies. It remains, however, to be clarified the neurobiological processes underlying prosody processing in WS. This study aimed at characterizing the electrophysiological response to neutral, happy, and angry prosody in WS, and examining if this response was dependent on the semantic content of the utterance. A group of 12 participants (5 female and 7male), diagnosed with WS, with age range between 9 and 31 years, was compared with a group of typically developing participants, individually matched for chronological age, gender and laterality. After inspection of EEG artifacts, data from 9 participants with WS and 10 controls were included in ERP analyses. Participants were presented with neutral, positive and negative sentences, in two conditions: (1) with intelligible semantic and syntactic information; (2) with unintelligible semantic and syntactic information (‘pure prosody’ condition). They were asked to decide which emotion was underlying the auditory sentence. Atypical event-related potentials (ERP) components were related with prosodic processing (N100, P200, N300) in WS. In particular, reduced N100 was observed for prosody sentences with semantic content; more positive P200 for sentences with semantic content, in particular for happy and angry intonations; and reduced N300 for both types of sentence conditions. These findings suggest abnormalities in early auditory processing, indicating a bottomup contribution to the impairment in emotional prosody processing and comprehension. Also, at least for N100 and P200, they suggest the top-down contributions of semantic processes in the sensory processing of speech. This study showed, for the first time, that abnormalities in ERP measures of early auditory processing in WS are also present during the processing of emotional vocal information. This may represent a physiological signature of underlying impaired on-line language and socio-emotional processing. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011 2011-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/11665 |
url |
http://hdl.handle.net/1822/11665 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pinheiro, A. P., Galdo-Álvarez, S., Rauber, A., Sampaio, A., Niznikiewicz, M., & Gonçalves, Ó. F. (2011). Abnormal processing of emotional prosody in Williams syndrome: An event-related potentials study. Research in Developmental Disabilities, 32(1), 133-147. doi: https://doi.org/10.1016/j.ridd.2010.09.011 0891-4222 10.1016/j.ridd.2010.09.011 20961731 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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mluisa.alvim@gmail.com |
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