Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review

Detalhes bibliográficos
Autor(a) principal: Cacodcar, Rita Sanjiva Sinai
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10284/9402
Resumo: Introduction: The growing number of osteonecrosis of the jaws cases associated with antiresorptive/antiangiogenic therapies is significant. The surgical treatment is still widely discussed. Objective: Evaluate how effective is the surgical therapy in the treatment of drug-induced osteonecrosis of the jaws. Methodology: PubMed and B-on, with English MESH terms, limited on humans and published between 2015-2019. Results: Of the 1478 articles found, 16 met the eligibility criteria. Total of 809 patients, 531 were females (65.9%), mean age was 70.47 years, and the follow-up range from 3-164 months. Surgical treatment had 84,06% of success. Highest results observed when patients were treated with laser-assisted surgery (87,50%). Conclusions: Surgical treatment in combination with antibiotic therapy, can present extremely beneficial results. Laser approach showed to be the most effective in promoting long-lasting palliative care, with resolution of pain and infection.
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spelling Surgical treatment of drug induced osteonecrosis of the jaws: a systematic reviewDiphosphonatesOsteonecrosisBisphosphonate associated osteonecrosis of the jawJawsAntiresorptive drugsDifosfonatosOsteonecroseOsteonecrose mandibular associada ao bisfosfonatoMaxilasMedicações anti-reabsortivasDomínio/Área Científica::Ciências Médicas::Medicina ClínicaIntroduction: The growing number of osteonecrosis of the jaws cases associated with antiresorptive/antiangiogenic therapies is significant. The surgical treatment is still widely discussed. Objective: Evaluate how effective is the surgical therapy in the treatment of drug-induced osteonecrosis of the jaws. Methodology: PubMed and B-on, with English MESH terms, limited on humans and published between 2015-2019. Results: Of the 1478 articles found, 16 met the eligibility criteria. Total of 809 patients, 531 were females (65.9%), mean age was 70.47 years, and the follow-up range from 3-164 months. Surgical treatment had 84,06% of success. Highest results observed when patients were treated with laser-assisted surgery (87,50%). Conclusions: Surgical treatment in combination with antibiotic therapy, can present extremely beneficial results. Laser approach showed to be the most effective in promoting long-lasting palliative care, with resolution of pain and infection.Introdução: O aumento de casos de osteonecrose dos maxilares associados a terapias antireabsortivas/antiangiogênicas é preocupante. O tratamento cirúrgico é ainda amplamente discutido. Objetivo: Avaliar a eficácia do tratamento cirúrgico da osteonecrose maxilar, induzida por medicação. Materiais e métodos: PubMed e B-on, com termos MESH em inglês, limitados a humanos e publicados entre 2015-2019. Resultados: Dos 1478 artigos encontrados, 16 preencheram os critérios de elegibilidade. Do total de 809 pacientes, 531 eram do sexo feminino (65,9%), a idade média foi 70.47 anos e o follow-up 3-164 meses. O tratamento cirúrgico teve 84,06% de sucesso. Foram obtidos resultados mais altos, quando tratados com cirurgia assistida por laser (87,50%). Conclusões: O tratamento cirúrgico associado à antibioticoterapia pode apresentar resultados extremamente benéficos. A abordagem a laser mostrou-se a mais eficaz na promoção de cuidados paliativos duradouros com resolução de dor e infeção.Trancoso, PedroRepositório Institucional da Universidade Fernando PessoaCacodcar, Rita Sanjiva Sinai2021-02-15T18:23:22Z2020-07-312020-07-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10284/9402TID:202718840enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-06-20T02:01:24Zoai:bdigital.ufp.pt:10284/9402Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:46:17.418334Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
title Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
spellingShingle Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
Cacodcar, Rita Sanjiva Sinai
Diphosphonates
Osteonecrosis
Bisphosphonate associated osteonecrosis of the jaw
Jaws
Antiresorptive drugs
Difosfonatos
Osteonecrose
Osteonecrose mandibular associada ao bisfosfonato
Maxilas
Medicações anti-reabsortivas
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
title_short Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
title_full Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
title_fullStr Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
title_full_unstemmed Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
title_sort Surgical treatment of drug induced osteonecrosis of the jaws: a systematic review
author Cacodcar, Rita Sanjiva Sinai
author_facet Cacodcar, Rita Sanjiva Sinai
author_role author
dc.contributor.none.fl_str_mv Trancoso, Pedro
Repositório Institucional da Universidade Fernando Pessoa
dc.contributor.author.fl_str_mv Cacodcar, Rita Sanjiva Sinai
dc.subject.por.fl_str_mv Diphosphonates
Osteonecrosis
Bisphosphonate associated osteonecrosis of the jaw
Jaws
Antiresorptive drugs
Difosfonatos
Osteonecrose
Osteonecrose mandibular associada ao bisfosfonato
Maxilas
Medicações anti-reabsortivas
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
topic Diphosphonates
Osteonecrosis
Bisphosphonate associated osteonecrosis of the jaw
Jaws
Antiresorptive drugs
Difosfonatos
Osteonecrose
Osteonecrose mandibular associada ao bisfosfonato
Maxilas
Medicações anti-reabsortivas
Domínio/Área Científica::Ciências Médicas::Medicina Clínica
description Introduction: The growing number of osteonecrosis of the jaws cases associated with antiresorptive/antiangiogenic therapies is significant. The surgical treatment is still widely discussed. Objective: Evaluate how effective is the surgical therapy in the treatment of drug-induced osteonecrosis of the jaws. Methodology: PubMed and B-on, with English MESH terms, limited on humans and published between 2015-2019. Results: Of the 1478 articles found, 16 met the eligibility criteria. Total of 809 patients, 531 were females (65.9%), mean age was 70.47 years, and the follow-up range from 3-164 months. Surgical treatment had 84,06% of success. Highest results observed when patients were treated with laser-assisted surgery (87,50%). Conclusions: Surgical treatment in combination with antibiotic therapy, can present extremely beneficial results. Laser approach showed to be the most effective in promoting long-lasting palliative care, with resolution of pain and infection.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-31
2020-07-31T00:00:00Z
2021-02-15T18:23:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10284/9402
TID:202718840
url http://hdl.handle.net/10284/9402
identifier_str_mv TID:202718840
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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