Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites

Detalhes bibliográficos
Autor(a) principal: Cravo, Pedro
Data de Publicação: 2018
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.25761/anaisihmt.30
Resumo: Malaria caused by Plasmodium falciparum represents one of the leading causes of child mortality in tropical and subtropical regions. Because no vaccine is available, treatment-based case management is the primary option for malaria control. However, over time, P. falciparum parasites have evolved resistance to all available drugs. Our group has developed a novel paradigm that brings together principles of classical genetics and innovative concepts of genomics, in order to understand the genetic and molecular basis of resistance to antimalarials. This strategy makes use of an isogenic lineage of the rodent parasite Plasmodium chabaudi, consisting of various clones that are either sensitive or resistant to different drugs, whose genomes are scrutinized in search for mutations responsible drug resistance. Using this strategy, the genetic basis of resistance to various antimalarials, such as pyrimethamine, chloroquine, mefloquine and artemisinin, has been clarified.
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spelling Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasitesEstratégia genómica para identificação rápida de mutações associadas a resistência a fármacos em parasitas de maláriaMalaria caused by Plasmodium falciparum represents one of the leading causes of child mortality in tropical and subtropical regions. Because no vaccine is available, treatment-based case management is the primary option for malaria control. However, over time, P. falciparum parasites have evolved resistance to all available drugs. Our group has developed a novel paradigm that brings together principles of classical genetics and innovative concepts of genomics, in order to understand the genetic and molecular basis of resistance to antimalarials. This strategy makes use of an isogenic lineage of the rodent parasite Plasmodium chabaudi, consisting of various clones that are either sensitive or resistant to different drugs, whose genomes are scrutinized in search for mutations responsible drug resistance. Using this strategy, the genetic basis of resistance to various antimalarials, such as pyrimethamine, chloroquine, mefloquine and artemisinin, has been clarified.A malária causada por Plasmodium falciparum representa uma das principais causas de mortalidade infantil em regiões tropicais e subtropicais. Dado não existir vacina disponível, o tratamento de casos é a principal opção para o controle da malária. No entanto, no decorrer do tempo, o parasita P. falciparum adquiriu resistência a todos os fármacos disponíveis. O nosso grupo desenvolveu um novo paradigma que congrega princípios de genética clássica e conceitos inovadores de genómica, no intuito de compreender as bases genéticas e moleculares da resistência a antimaláricos. Esta estratégia faz uso de uma linhagem isogénica do parasita de roedores Plasmodium chabaudi, constituída por clones sensíveis ou resistentes a diversos fármacos, cujos genomas são escrutinados na procura de mutações responsáveis pela farmacoresistência. Usando esta estratégia, foram clarificadas as bases genéticas da resistência a vários antimaláricos, tais como pirimetamina, cloroquina, mefloquina e artemisinina.Universidade Nova de Lisboa2018-04-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.25761/anaisihmt.30oai:ojs.anaisihmt.com:article/30Anais do Instituto de Higiene e Medicina Tropical; Vol 16 (2017):  4.º Congresso Nacional de Medicina Tropical; 65-68Anais do Instituto de Higiene e Medicina Tropical; v. 16 (2017):  4.º Congresso Nacional de Medicina Tropical; 65-682184-23100303-7762reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttp://anaisihmt.com/index.php/ihmt/article/view/30https://doi.org/10.25761/anaisihmt.30http://anaisihmt.com/index.php/ihmt/article/view/30/24Cravo, Pedroinfo:eu-repo/semantics/openAccess2022-09-23T15:30:15Zoai:ojs.anaisihmt.com:article/30Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:03:50.540511Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
Estratégia genómica para identificação rápida de mutações associadas a resistência a fármacos em parasitas de malária
title Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
spellingShingle Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
Cravo, Pedro
title_short Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
title_full Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
title_fullStr Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
title_full_unstemmed Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
title_sort Genomics strategy for rapid identification of mutations associated with drug resistance in malaria parasites
author Cravo, Pedro
author_facet Cravo, Pedro
author_role author
dc.contributor.author.fl_str_mv Cravo, Pedro
description Malaria caused by Plasmodium falciparum represents one of the leading causes of child mortality in tropical and subtropical regions. Because no vaccine is available, treatment-based case management is the primary option for malaria control. However, over time, P. falciparum parasites have evolved resistance to all available drugs. Our group has developed a novel paradigm that brings together principles of classical genetics and innovative concepts of genomics, in order to understand the genetic and molecular basis of resistance to antimalarials. This strategy makes use of an isogenic lineage of the rodent parasite Plasmodium chabaudi, consisting of various clones that are either sensitive or resistant to different drugs, whose genomes are scrutinized in search for mutations responsible drug resistance. Using this strategy, the genetic basis of resistance to various antimalarials, such as pyrimethamine, chloroquine, mefloquine and artemisinin, has been clarified.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.25761/anaisihmt.30
oai:ojs.anaisihmt.com:article/30
url https://doi.org/10.25761/anaisihmt.30
identifier_str_mv oai:ojs.anaisihmt.com:article/30
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv http://anaisihmt.com/index.php/ihmt/article/view/30
https://doi.org/10.25761/anaisihmt.30
http://anaisihmt.com/index.php/ihmt/article/view/30/24
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Nova de Lisboa
publisher.none.fl_str_mv Universidade Nova de Lisboa
dc.source.none.fl_str_mv Anais do Instituto de Higiene e Medicina Tropical; Vol 16 (2017):  4.º Congresso Nacional de Medicina Tropical; 65-68
Anais do Instituto de Higiene e Medicina Tropical; v. 16 (2017):  4.º Congresso Nacional de Medicina Tropical; 65-68
2184-2310
0303-7762
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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