Chronic Hepatitis C Treatment in HIV Co-Infection in Portugal: Results from a Cohort OF 2133 Patients Presented by GEPCOI (Portuguese Coinfection Study Group)

• Autor(a) principal: Miranda, AC
• Data de Publicação: 2020
• Outros Autores: Mendez, J, Serrão, R, Vale, F, Manata, MJ, Pinto, S, Gomes, A, Valente, C, Pacheco, P, Pazos, R, Pereira, R, Martins, A, Germano, I, Rocha, S, Reis, AP, Sarmento-Castro, R
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.17/4046
• topic: HCC INF; Adult; Aged; Female; Antiviral Agents* / therapeutic use; Male; Middle Aged; Coinfection* / drug therapy; Drug Therapy, Combination; Genotype; HIV Infections* / drug therapy; Hepacivirus; Hepatitis C, Chronic* / drug therapy; Humans; Nigeria; Portugal; Quality of Life; Young Adult; Sofosbuvir / therapeutic use; Treatment Outcome

Direct-acting antiviral drugs (DAAs) have recently changed the paradigm of hepatitis C therapy, significantly improving treatment response rates, patient life expectancy and quality of life. In Portugal, sofosbuvir (SOF) and SOF/ledipasvir (SOF/LDV) were fully reimbursed by the National Health System since early 2015 and generalized use of interferon-free DAA based regimens became current practice. During 2016, the remaining DAAs were sequentially added and covered by the same health access policy. The Portuguese Study Group of Hepatitis and HIV Co-infection (GEPCOI) collected data from 15 clinical centres in Portugal, pertaining to the HCV treatment experience with DAA regimens. A cohort of 2133 patients was analysed, representing one of the largest DAA treated HCV/HIV co-infected individuals. The global sustained virologic response (SVR) achieved was 95% in this real-life cohort setting. Linear regression analysis showed significant differences in treatment response rates when using SOF plus ribavirin (RBV) combination in genotype 2 or 3 infected individuals (P < .002) and in those with liver cirrhosis (P < .002). These findings corroborate that early treatment is mandatory in HIV/HCV co-infected patients, as response rates may be negatively influenced by higher fibrosis stages and suboptimal DAA regimens. The current national Portuguese health policy should continue to promote wider treatment access and individualized therapy strategies, aiming at the elimination of HCV infection in this high-risk co-infected population.