Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer

Detalhes bibliográficos
Autor(a) principal: Marcelo, Gonçalo A.
Data de Publicação: 2023
Outros Autores: Montpeyó, David, Galhano, Joana, Martínez-Máñez, Ramón, Capelo-Martínez, José Luis, Lorenzo, Julia, Lodeiro, Carlos, Oliveira, Elisabete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153149
Resumo: Funding Information: G.M. acknowledges the financial support by the Associate Laboratory Research Unit for Green Chemistry—Clean Processes and Technologies—LAQV, which is co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER—007265), as well as the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant). J.L. acknowledges the funding received from the Ministerio de Ciencia, Innovación y Universidades, Spain, grant PID2021-127983OB-C22 funded by MCIN/AEI/10.13039/501100011033. RMM acknowledges the funding received from project PID2021-126304OB-C41 funded by MCIN/AEI /10.13039/501100011033/ and by European Regional Development Fund—A way of doing Europe and Generalitat Valenciana (CIPROM/2021/007). Publisher Copyright: © 2023 by the authors.
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spelling Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancercolorectal canceroral formulationstarget drug deliverytarget nanocarrierstargeted anticancer therapyCatalysisMolecular BiologySpectroscopyComputer Science ApplicationsPhysical and Theoretical ChemistryOrganic ChemistryInorganic ChemistrySDG 3 - Good Health and Well-beingFunding Information: G.M. acknowledges the financial support by the Associate Laboratory Research Unit for Green Chemistry—Clean Processes and Technologies—LAQV, which is co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER—007265), as well as the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant). J.L. acknowledges the funding received from the Ministerio de Ciencia, Innovación y Universidades, Spain, grant PID2021-127983OB-C22 funded by MCIN/AEI/10.13039/501100011033. RMM acknowledges the funding received from project PID2021-126304OB-C41 funded by MCIN/AEI /10.13039/501100011033/ and by European Regional Development Fund—A way of doing Europe and Generalitat Valenciana (CIPROM/2021/007). Publisher Copyright: © 2023 by the authors.The need for non-invasive therapies capable of conserving drug efficiency and stability while having specific targetability against colorectal cancer (CRC), has made nanoparticles preferable vehicles and principal building blocks for the development of complex and multi-action anti-tumoral approaches. For that purpose, we herein report the production of a combinatory anti-tumoral nanotherapy using the production of a new targeting towards CRC lines. To do so, Magneto-fluorescent NANO3 nanoparticles were used as nanocarriers for a combination of the drugs doxorubicin (DOX) and ofloxacin (OFLO). NANO3 nanoparticles’ surface was modified with two different targeting agents, a newly synthesized (anti-CA IX acetazolamide derivative (AZM-SH)) and a commercially available (anti-epidermal growth factor receptor (EGFR), Cetuximab). The cytotoxicity revealed that only DOX-containing nanosystems showed significant and even competitive cytotoxicity when compared to that of free DOX. Interestingly, surface modification with AZM-SH promoted an increased cellular uptake in the HCT116 cell line, surpassing even those functionalized with Cetuximab. The results show that the new target has high potential to be used as a nanotherapy agent for CRC cells, surpassing commercial targets. As a proof-of-concept, an oral administration form of NANO3 systems was successfully combined with Eudragit® enteric coating and studied under extreme conditions.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNMarcelo, Gonçalo A.Montpeyó, DavidGalhano, JoanaMartínez-Máñez, RamónCapelo-Martínez, José LuisLorenzo, JuliaLodeiro, CarlosOliveira, Elisabete2023-05-24T22:52:56Z2023-04-012023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23application/pdfhttp://hdl.handle.net/10362/153149eng1661-6596PURE: 61460724https://doi.org/10.3390/ijms24076612info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:35:45Zoai:run.unl.pt:10362/153149Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:12.057397Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
title Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
spellingShingle Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
Marcelo, Gonçalo A.
colorectal cancer
oral formulations
target drug delivery
target nanocarriers
targeted anticancer therapy
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
title_short Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
title_full Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
title_fullStr Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
title_full_unstemmed Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
title_sort Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
author Marcelo, Gonçalo A.
author_facet Marcelo, Gonçalo A.
Montpeyó, David
Galhano, Joana
Martínez-Máñez, Ramón
Capelo-Martínez, José Luis
Lorenzo, Julia
Lodeiro, Carlos
Oliveira, Elisabete
author_role author
author2 Montpeyó, David
Galhano, Joana
Martínez-Máñez, Ramón
Capelo-Martínez, José Luis
Lorenzo, Julia
Lodeiro, Carlos
Oliveira, Elisabete
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Marcelo, Gonçalo A.
Montpeyó, David
Galhano, Joana
Martínez-Máñez, Ramón
Capelo-Martínez, José Luis
Lorenzo, Julia
Lodeiro, Carlos
Oliveira, Elisabete
dc.subject.por.fl_str_mv colorectal cancer
oral formulations
target drug delivery
target nanocarriers
targeted anticancer therapy
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
topic colorectal cancer
oral formulations
target drug delivery
target nanocarriers
targeted anticancer therapy
Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
SDG 3 - Good Health and Well-being
description Funding Information: G.M. acknowledges the financial support by the Associate Laboratory Research Unit for Green Chemistry—Clean Processes and Technologies—LAQV, which is co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER—007265), as well as the Scientific Society PROTEOMASS (Portugal) for funding support (General Funding Grant). J.L. acknowledges the funding received from the Ministerio de Ciencia, Innovación y Universidades, Spain, grant PID2021-127983OB-C22 funded by MCIN/AEI/10.13039/501100011033. RMM acknowledges the funding received from project PID2021-126304OB-C41 funded by MCIN/AEI /10.13039/501100011033/ and by European Regional Development Fund—A way of doing Europe and Generalitat Valenciana (CIPROM/2021/007). Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-24T22:52:56Z
2023-04-01
2023-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153149
url http://hdl.handle.net/10362/153149
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
PURE: 61460724
https://doi.org/10.3390/ijms24076612
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 23
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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