Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Dissertação |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/31085 |
Resumo: | Background: Periodontitis is the most prevalent inflammatory disease worldwide. Different authors have proposed that periodontal inflammation spreads systemically being associated with cardiovascular disease, the most frequent death cause in chronic kidney disease patients. Salivary biomarkers have a big potential in the diagnosis and correlation of both diseases, it can also be important in monitoring the systemic inflammation. Aim: Therefore, the aim of this study is to analyse the association between chronic kidney disease and periodontitis / periimplantitis by analysing salivary biomarkers. Materials and methods: A systematic electronic search through PubMed (MEDLINE), EMBASE and Web of Science databases was conducted by three independent reviewers to identify clinical studies performed in humans and published between January 2009 and January 2020, with no geographical or language restrictions. This systematic review followed the PRISMA guidelines. The present systematic review was registered in the PROSPERO. Results: Search strategy identified 7051 protentional eligible articles but only one met all the inclusion and exclusion criteria. The included article studied 4 salivary biomarkers, sTrem-1, PYGLRP1, IL-1β and MMP-8 in patients at predialysis stage with a follow-up of 157 months. Study results, by a confounders analysis, showed that periodontitis had a significant influence increasing the values of these inflammatory biomarkers. Conclusion: A direct cause-effect association between periodontitis and CKD cannot be established, but this work concludes that there was an effect correlating them through the analysed proinflammatory biomarkers. More controlled studies are suggested to reinforce this weak conclusion. |
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Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic reviewPeriodontitisPeriimplantitisChronic kidney diseaseSalivary biomarkersSystematic reviewPeriodontitePeri-implantiteDoença renal crónicaBiomarcadores salivaresRevisão sistemáticaDomínio/Área Científica::Ciências Médicas::Ciências da SaúdeBackground: Periodontitis is the most prevalent inflammatory disease worldwide. Different authors have proposed that periodontal inflammation spreads systemically being associated with cardiovascular disease, the most frequent death cause in chronic kidney disease patients. Salivary biomarkers have a big potential in the diagnosis and correlation of both diseases, it can also be important in monitoring the systemic inflammation. Aim: Therefore, the aim of this study is to analyse the association between chronic kidney disease and periodontitis / periimplantitis by analysing salivary biomarkers. Materials and methods: A systematic electronic search through PubMed (MEDLINE), EMBASE and Web of Science databases was conducted by three independent reviewers to identify clinical studies performed in humans and published between January 2009 and January 2020, with no geographical or language restrictions. This systematic review followed the PRISMA guidelines. The present systematic review was registered in the PROSPERO. Results: Search strategy identified 7051 protentional eligible articles but only one met all the inclusion and exclusion criteria. The included article studied 4 salivary biomarkers, sTrem-1, PYGLRP1, IL-1β and MMP-8 in patients at predialysis stage with a follow-up of 157 months. Study results, by a confounders analysis, showed that periodontitis had a significant influence increasing the values of these inflammatory biomarkers. Conclusion: A direct cause-effect association between periodontitis and CKD cannot be established, but this work concludes that there was an effect correlating them through the analysed proinflammatory biomarkers. More controlled studies are suggested to reinforce this weak conclusion.Introdução: A periodontite é a doença inflamatória mais prevalente no mundo. Vários autores propõem que a inflamação periodontal difunde-se sistematicamente, sendo associada á doença cardiovascular, sendo esta a causa de morte mais frequente em pacientes com doença renal crónica (CKD). Os biomarcadores salivares têm um grande potencial no diagnóstico e na correlação de ambas as doenças, podem também ser importantes na monitorização da inflamação sistémica. Objetivo: Desta forma, o objetivo deste estudo é analisar a associação entre a doença renal crônica e a periodontite / periimplantite, analisando biomarcadores salivares. Materiais e métodos: Realizou-se uma pesquisa eletrónica sistemática nas bases de dados PubMed (MEDLINE), EMBASE e Web of Science, esta foi conduzida por três revisores independentes de forma a identificar estudos clínicos realizados em seres humanos publicados entre janeiro de 2009 e janeiro de 2020, sem restrições geográficas ou de idioma. Esta revisão sistemática seguiu as diretrizes do PRISMA. A presente revisão sistemática foi registada no PROSPERO. Resultados: A estratégia de pesquisa identificou 7051 artigos, mas apenas um atendeu a todos os critérios de inclusão e exclusão. O artigo incluído estudou 4 biomarcadores salivares, sTrem-1, PYGLRP1, IL-1βeMMP -8 em pacientes na fase pré-diálise com follow-up de 157 meses. Os resultados do estudo, por meio de uma análise de fatores de confusão, mostraram que a periodontite teve uma influência significativa no aumento dos valores desses biomarcadores inflamatórios. Conclusão: Não é possível estabelecer uma relação direta de causa-efeito entre a periodontite e a doença renal crónica, mas este trabalho conclui que um efeito correlacionando através dos biomarcadores pró-inflamatórios analisados pode ser causado. Mais estudos controlados são sugeridos para reforçar essa conclusão fraca.Fernandes, Gustavo Vicentis de OliveiraVeiga, Nélio JorgeVeritati - Repositório Institucional da Universidade Católica PortuguesaTavares, Lisandra Taísa Reginaldo2020-10-12T09:52:36Z2020-08-1920202020-08-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.14/31085TID:202509346enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:36:29Zoai:repositorio.ucp.pt:10400.14/31085Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:24:53.472693Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
title |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
spellingShingle |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review Tavares, Lisandra Taísa Reginaldo Periodontitis Periimplantitis Chronic kidney disease Salivary biomarkers Systematic review Periodontite Peri-implantite Doença renal crónica Biomarcadores salivares Revisão sistemática Domínio/Área Científica::Ciências Médicas::Ciências da Saúde |
title_short |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
title_full |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
title_fullStr |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
title_full_unstemmed |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
title_sort |
Salivary protein in patients with Chronic Kidney Disease : associated to periodontal and peri-implant disease : systematic review |
author |
Tavares, Lisandra Taísa Reginaldo |
author_facet |
Tavares, Lisandra Taísa Reginaldo |
author_role |
author |
dc.contributor.none.fl_str_mv |
Fernandes, Gustavo Vicentis de Oliveira Veiga, Nélio Jorge Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Tavares, Lisandra Taísa Reginaldo |
dc.subject.por.fl_str_mv |
Periodontitis Periimplantitis Chronic kidney disease Salivary biomarkers Systematic review Periodontite Peri-implantite Doença renal crónica Biomarcadores salivares Revisão sistemática Domínio/Área Científica::Ciências Médicas::Ciências da Saúde |
topic |
Periodontitis Periimplantitis Chronic kidney disease Salivary biomarkers Systematic review Periodontite Peri-implantite Doença renal crónica Biomarcadores salivares Revisão sistemática Domínio/Área Científica::Ciências Médicas::Ciências da Saúde |
description |
Background: Periodontitis is the most prevalent inflammatory disease worldwide. Different authors have proposed that periodontal inflammation spreads systemically being associated with cardiovascular disease, the most frequent death cause in chronic kidney disease patients. Salivary biomarkers have a big potential in the diagnosis and correlation of both diseases, it can also be important in monitoring the systemic inflammation. Aim: Therefore, the aim of this study is to analyse the association between chronic kidney disease and periodontitis / periimplantitis by analysing salivary biomarkers. Materials and methods: A systematic electronic search through PubMed (MEDLINE), EMBASE and Web of Science databases was conducted by three independent reviewers to identify clinical studies performed in humans and published between January 2009 and January 2020, with no geographical or language restrictions. This systematic review followed the PRISMA guidelines. The present systematic review was registered in the PROSPERO. Results: Search strategy identified 7051 protentional eligible articles but only one met all the inclusion and exclusion criteria. The included article studied 4 salivary biomarkers, sTrem-1, PYGLRP1, IL-1β and MMP-8 in patients at predialysis stage with a follow-up of 157 months. Study results, by a confounders analysis, showed that periodontitis had a significant influence increasing the values of these inflammatory biomarkers. Conclusion: A direct cause-effect association between periodontitis and CKD cannot be established, but this work concludes that there was an effect correlating them through the analysed proinflammatory biomarkers. More controlled studies are suggested to reinforce this weak conclusion. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-12T09:52:36Z 2020-08-19 2020 2020-08-19T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/31085 TID:202509346 |
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http://hdl.handle.net/10400.14/31085 |
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TID:202509346 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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