Dendrimers in tissue engineering

Detalhes bibliográficos
Autor(a) principal: Oliveira, Isabel Maria Lopes Matos
Data de Publicação: 2021
Outros Autores: Carvalho, Mariana Rodrigues, Reis, R. L., Oliveira, J. M.
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/77823
Resumo: Dendrimers are highly branched and multivalent, and monodispersive making them perfect candidates for a myriad of controlled drug delivery applications. Dendrimers possess many other advantages, such as the possibility of modulating surface chemistry and charge, and biodegradation rate and to be processed as scaffolds that can emulate natural extracellular matrices thus opening up unique applications in tissue engineering. The combination of dendrimers and other macromolecules (proteins and carbohydrates), as well as other traditional scaffold polymers, has led to the creation of hybrid scaffolds with new physical, mechanical, and biochemical properties. However, despite the widespread use of dendrimers in biomedical applications, their use in the fabrication of tissue engineering scaffolds remains some-how narrow. The most promising applications of dendritic macromolecules in TE area such as drug delivery strategies, cell differentiation and/or tissue regeneration, 3D/Dynamic platforms and ex vivo/in vivo testing are overviewed and discussed herein.
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spelling Dendrimers in tissue engineeringDendrimersNanotherapeuticsNanoparticlesTissue engineeringDrug deliveryMicrofluidicsDendrimers are highly branched and multivalent, and monodispersive making them perfect candidates for a myriad of controlled drug delivery applications. Dendrimers possess many other advantages, such as the possibility of modulating surface chemistry and charge, and biodegradation rate and to be processed as scaffolds that can emulate natural extracellular matrices thus opening up unique applications in tissue engineering. The combination of dendrimers and other macromolecules (proteins and carbohydrates), as well as other traditional scaffold polymers, has led to the creation of hybrid scaffolds with new physical, mechanical, and biochemical properties. However, despite the widespread use of dendrimers in biomedical applications, their use in the fabrication of tissue engineering scaffolds remains some-how narrow. The most promising applications of dendritic macromolecules in TE area such as drug delivery strategies, cell differentiation and/or tissue regeneration, 3D/Dynamic platforms and ex vivo/in vivo testing are overviewed and discussed herein.JMO for the financial support provided under the program “Investigador FCT” (IF/01285/2015). MCR acknowledges the IET Institution of Engineering and Technology for the financial support provided under the IET Harvey Research Prize 2017. IMO thanks the financial support under the Norte2020 project (“NORTE-08-5369-FSE-000044”).ElsevierUniversidade do MinhoOliveira, Isabel Maria Lopes MatosCarvalho, Mariana RodriguesReis, R. L.Oliveira, J. M.2021-042021-04-01T00:00:00Zbook partinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/1822/77823engOliveira I. M., Carvalho M. R., Reis R. L., Oliveira J. M. Dendrimes in Tissue Engineering, Dendrimer-Based Nanotherapeutics, pp. 1-449, 978-0-12-821250-9, 2021978-0-12-821250-910.1016/B978-0-12-821250-9.00008-1https://doi.org/10.1016/B978-0-12-821250-9.00008-1info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T05:06:29Zoai:repositorium.sdum.uminho.pt:1822/77823Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T05:06:29Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dendrimers in tissue engineering
title Dendrimers in tissue engineering
spellingShingle Dendrimers in tissue engineering
Oliveira, Isabel Maria Lopes Matos
Dendrimers
Nanotherapeutics
Nanoparticles
Tissue engineering
Drug delivery
Microfluidics
title_short Dendrimers in tissue engineering
title_full Dendrimers in tissue engineering
title_fullStr Dendrimers in tissue engineering
title_full_unstemmed Dendrimers in tissue engineering
title_sort Dendrimers in tissue engineering
author Oliveira, Isabel Maria Lopes Matos
author_facet Oliveira, Isabel Maria Lopes Matos
Carvalho, Mariana Rodrigues
Reis, R. L.
Oliveira, J. M.
author_role author
author2 Carvalho, Mariana Rodrigues
Reis, R. L.
Oliveira, J. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Oliveira, Isabel Maria Lopes Matos
Carvalho, Mariana Rodrigues
Reis, R. L.
Oliveira, J. M.
dc.subject.por.fl_str_mv Dendrimers
Nanotherapeutics
Nanoparticles
Tissue engineering
Drug delivery
Microfluidics
topic Dendrimers
Nanotherapeutics
Nanoparticles
Tissue engineering
Drug delivery
Microfluidics
description Dendrimers are highly branched and multivalent, and monodispersive making them perfect candidates for a myriad of controlled drug delivery applications. Dendrimers possess many other advantages, such as the possibility of modulating surface chemistry and charge, and biodegradation rate and to be processed as scaffolds that can emulate natural extracellular matrices thus opening up unique applications in tissue engineering. The combination of dendrimers and other macromolecules (proteins and carbohydrates), as well as other traditional scaffold polymers, has led to the creation of hybrid scaffolds with new physical, mechanical, and biochemical properties. However, despite the widespread use of dendrimers in biomedical applications, their use in the fabrication of tissue engineering scaffolds remains some-how narrow. The most promising applications of dendritic macromolecules in TE area such as drug delivery strategies, cell differentiation and/or tissue regeneration, 3D/Dynamic platforms and ex vivo/in vivo testing are overviewed and discussed herein.
publishDate 2021
dc.date.none.fl_str_mv 2021-04
2021-04-01T00:00:00Z
dc.type.driver.fl_str_mv book part
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/77823
url https://hdl.handle.net/1822/77823
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oliveira I. M., Carvalho M. R., Reis R. L., Oliveira J. M. Dendrimes in Tissue Engineering, Dendrimer-Based Nanotherapeutics, pp. 1-449, 978-0-12-821250-9, 2021
978-0-12-821250-9
10.1016/B978-0-12-821250-9.00008-1
https://doi.org/10.1016/B978-0-12-821250-9.00008-1
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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