Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse

Detalhes bibliográficos
Autor(a) principal: Lilue, Jingtao
Data de Publicação: 2013
Outros Autores: Müller, Urs Benedikt, Steinfeldt, Tobias, Howard, Jonathan C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/456
Resumo: Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI:http://dx.doi.org/10.7554/eLife.01298.001.
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spelling Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouseVirulencePolymorphism, GeneticToxoplasmaToxoplasmaVirulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI:http://dx.doi.org/10.7554/eLife.01298.001.Deutsche Forschungsgemeinschaft (SFB 680, SFB 635, SFB 670, SPP 1399), International Graduate School in Development Health and Disease.Elife Sciences PublicationsARCALilue, JingtaoMüller, Urs BenediktSteinfeldt, TobiasHoward, Jonathan C2015-10-30T16:08:50Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/456eng10.7554/eLife.01298info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:50Zoai:arca.igc.gulbenkian.pt:10400.7/456Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:44.355710Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
title Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
spellingShingle Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
Lilue, Jingtao
Virulence
Polymorphism, Genetic
Toxoplasma
Toxoplasma
title_short Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
title_full Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
title_fullStr Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
title_full_unstemmed Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
title_sort Reciprocal virulence and resistance polymorphism in the relationship betweenToxoplasma gondiiand the house mouse
author Lilue, Jingtao
author_facet Lilue, Jingtao
Müller, Urs Benedikt
Steinfeldt, Tobias
Howard, Jonathan C
author_role author
author2 Müller, Urs Benedikt
Steinfeldt, Tobias
Howard, Jonathan C
author2_role author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Lilue, Jingtao
Müller, Urs Benedikt
Steinfeldt, Tobias
Howard, Jonathan C
dc.subject.por.fl_str_mv Virulence
Polymorphism, Genetic
Toxoplasma
Toxoplasma
topic Virulence
Polymorphism, Genetic
Toxoplasma
Toxoplasma
description Virulence in the ubiquitous intracellular protozoon Toxoplasma gondii for its natural intermediate host, the mouse, appears paradoxical from an evolutionary standpoint because death of the mouse before encystment interrupts the parasite life cycle. Virulent T. gondii strains secrete kinases and pseudokinases that inactivate the immunity-related GTPases (IRG proteins) responsible for mouse resistance to avirulent strains. Such considerations stimulated a search for IRG alleles unknown in laboratory mice that might confer resistance to virulent strains of T. gondii. We report that the mouse IRG system shows extraordinary polymorphic complexity in the wild. We describe an IRG haplotype from a wild-derived mouse strain that confers resistance against virulent parasites by interference with the virulent kinase complex. In such hosts virulent strains can encyst, hinting at an explanation for the evolution of virulence polymorphism in T. gondii. DOI:http://dx.doi.org/10.7554/eLife.01298.001.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2015-10-30T16:08:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/456
url http://hdl.handle.net/10400.7/456
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.7554/eLife.01298
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elife Sciences Publications
publisher.none.fl_str_mv Elife Sciences Publications
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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