Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential

Detalhes bibliográficos
Autor(a) principal: Emran, Talha
Data de Publicação: 2022
Outros Autores: Islam, Fahadul, Mitra, Saikat, Paul, Shyamjit, Nath, Nikhil, Khan, Zidan, Das, Rajib, Chandran, Deepak, Sharma, Rohit, Lima, Clara Mariana, Awadh, Ahmed Abdullah Al, Almazni, Ibrahim Abdullah, Alhasaniah, Abdulaziz Hassan, Guiné, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.19/7368
Resumo: Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing long-term chronic diseases like diabetes and heart disease is an important role of dietary carbohydrates. Colon and breast cancer are among the diseases for which data suggest that modified pectin (MP), specifically modified citrus pectin (MCP), has beneficial effects on the development and spread of malignancies, in addition to its benefits as a soluble dietary fiber. Cellular and animal studies and human clinical trials have provided corroborating data. Although pectin has many diverse functional qualities, this review focuses on various modifications used to develop MP and its benefits for cancer prevention, bioavailability, clinical trials, and toxicity studies. This review concludes that pectin has anti-cancer characteristics that have been found to inhibit tumor development and proliferation in a wide variety of cancer cells. Nevertheless, further clinical and basic research is required to confirm the chemopreventive or therapeutic role of specific dietary carbohydrate molecules.
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spelling Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potentialpectinmodified citrus pectinapoptosisfood polysaccharidecancerPectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing long-term chronic diseases like diabetes and heart disease is an important role of dietary carbohydrates. Colon and breast cancer are among the diseases for which data suggest that modified pectin (MP), specifically modified citrus pectin (MCP), has beneficial effects on the development and spread of malignancies, in addition to its benefits as a soluble dietary fiber. Cellular and animal studies and human clinical trials have provided corroborating data. Although pectin has many diverse functional qualities, this review focuses on various modifications used to develop MP and its benefits for cancer prevention, bioavailability, clinical trials, and toxicity studies. This review concludes that pectin has anti-cancer characteristics that have been found to inhibit tumor development and proliferation in a wide variety of cancer cells. Nevertheless, further clinical and basic research is required to confirm the chemopreventive or therapeutic role of specific dietary carbohydrate molecules.MDPIRepositório Científico do Instituto Politécnico de ViseuEmran, TalhaIslam, FahadulMitra, SaikatPaul, ShyamjitNath, NikhilKhan, ZidanDas, RajibChandran, DeepakSharma, RohitLima, Clara MarianaAwadh, Ahmed Abdullah AlAlmazni, Ibrahim AbdullahAlhasaniah, Abdulaziz HassanGuiné, Raquel2022-11-11T11:45:25Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.19/7368engEmran TB, Islam F, Mitra S, Paul S, Nath N, Khan Z, Das R, Chandran D, Sharma R, Lima CMG, Awadh AAA, Almazni IA, Alhasaniah AH, Guiné RPF. (2022) Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential. Molecules, 27(21), 7405: 1-2110.3390/molecules27217405info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T15:29:31Zoai:repositorio.ipv.pt:10400.19/7368Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:45:06.250726Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
title Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
spellingShingle Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
Emran, Talha
pectin
modified citrus pectin
apoptosis
food polysaccharide
cancer
title_short Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
title_full Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
title_fullStr Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
title_full_unstemmed Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
title_sort Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential
author Emran, Talha
author_facet Emran, Talha
Islam, Fahadul
Mitra, Saikat
Paul, Shyamjit
Nath, Nikhil
Khan, Zidan
Das, Rajib
Chandran, Deepak
Sharma, Rohit
Lima, Clara Mariana
Awadh, Ahmed Abdullah Al
Almazni, Ibrahim Abdullah
Alhasaniah, Abdulaziz Hassan
Guiné, Raquel
author_role author
author2 Islam, Fahadul
Mitra, Saikat
Paul, Shyamjit
Nath, Nikhil
Khan, Zidan
Das, Rajib
Chandran, Deepak
Sharma, Rohit
Lima, Clara Mariana
Awadh, Ahmed Abdullah Al
Almazni, Ibrahim Abdullah
Alhasaniah, Abdulaziz Hassan
Guiné, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Viseu
dc.contributor.author.fl_str_mv Emran, Talha
Islam, Fahadul
Mitra, Saikat
Paul, Shyamjit
Nath, Nikhil
Khan, Zidan
Das, Rajib
Chandran, Deepak
Sharma, Rohit
Lima, Clara Mariana
Awadh, Ahmed Abdullah Al
Almazni, Ibrahim Abdullah
Alhasaniah, Abdulaziz Hassan
Guiné, Raquel
dc.subject.por.fl_str_mv pectin
modified citrus pectin
apoptosis
food polysaccharide
cancer
topic pectin
modified citrus pectin
apoptosis
food polysaccharide
cancer
description Pectin is an acidic heteropolysaccharide found in the cell walls and the primary and middle lamella of land plants. To be authorized as a food additive, industrial pectins must meet strict guidelines set forth by the Food and Agricultural Organization and must contain at least 65% polygalacturonic acid to achieve the E440 level. Fruit pectin derived from oranges or apples is commonly used in the food industry to gel or thicken foods and to stabilize acid-based milk beverages. It is a naturally occurring component and can be ingested by dietary consumption of fruit and vegetables. Preventing long-term chronic diseases like diabetes and heart disease is an important role of dietary carbohydrates. Colon and breast cancer are among the diseases for which data suggest that modified pectin (MP), specifically modified citrus pectin (MCP), has beneficial effects on the development and spread of malignancies, in addition to its benefits as a soluble dietary fiber. Cellular and animal studies and human clinical trials have provided corroborating data. Although pectin has many diverse functional qualities, this review focuses on various modifications used to develop MP and its benefits for cancer prevention, bioavailability, clinical trials, and toxicity studies. This review concludes that pectin has anti-cancer characteristics that have been found to inhibit tumor development and proliferation in a wide variety of cancer cells. Nevertheless, further clinical and basic research is required to confirm the chemopreventive or therapeutic role of specific dietary carbohydrate molecules.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-11T11:45:25Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.19/7368
url http://hdl.handle.net/10400.19/7368
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Emran TB, Islam F, Mitra S, Paul S, Nath N, Khan Z, Das R, Chandran D, Sharma R, Lima CMG, Awadh AAA, Almazni IA, Alhasaniah AH, Guiné RPF. (2022) Pectin: A Bioactive Food Polysaccharide with Cancer Preventive Potential. Molecules, 27(21), 7405: 1-21
10.3390/molecules27217405
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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