Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol

Detalhes bibliográficos
Autor(a) principal: Araújo, Diana
Data de Publicação: 2023
Outros Autores: Martins, Matilde, Concórdio-Reis, Patrícia, Roma-Rodrigues, Catarina, Morais, Maria, Alves, Vítor D., Fernandes, Alexandra R., Freitas, Filomena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/159722
Resumo: Publisher Copyright: © 2023 by the authors.
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spelling Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPolDesign, Characterization and Biological Propertiesanti-inflammatory activitybiocompatibilityFucoPolhydrogel membranesionotropic gelationMolecular MedicinePharmaceutical ScienceDrug DiscoveryPublisher Copyright: © 2023 by the authors.FucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe3+ as a crosslinking agent. This study evaluated the impact of Fe3+ and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe3+ concentration had a limited influence on the HMs’ strength, and varying the FucoPol concentration had a more significant effect. Three different FucoPol concentrations (1.0, 1.75 and 2.5 wt.%) were combined with Fe3+ (1.5 g/L), resulting in HMs with a water content above 97 wt.% and an Fe3+ content up to 0.16 wt.%. HMs with lower FucoPol content exhibited a denser porous microstructure as the polymer concentration increased. Moreover, the low polymer content HM presented the highest swelling ratio (22.3 ± 1.8 g/g) and a lower hardness value (32.4 ± 5.8 kPa). However, improved mechanical properties (221.9 ± 10.2 kPa) along with a decrease in the swelling ratio (11.9 ± 1.6 g/g) were obtained for HMs with a higher polymer content. Furthermore, all HMs were non-cytotoxic and revealed anti-inflammatory activity. The incorporation of FucoPol as a structuring agent and bioactive ingredient in the development of HMs opens up new possibilities for its use in tissue engineering, drug delivery and wound care management.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaDCV - Departamento de Ciências da VidaDCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNAraújo, DianaMartins, MatildeConcórdio-Reis, PatríciaRoma-Rodrigues, CatarinaMorais, MariaAlves, Vítor D.Fernandes, Alexandra R.Freitas, Filomena2023-11-08T22:09:23Z2023-07-112023-07-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23application/pdfhttp://hdl.handle.net/10362/159722eng1424-8247PURE: 75686880https://doi.org/10.3390/ph16070991info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:10Zoai:run.unl.pt:10362/159722Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:40.557673Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
Design, Characterization and Biological Properties
title Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
spellingShingle Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
Araújo, Diana
anti-inflammatory activity
biocompatibility
FucoPol
hydrogel membranes
ionotropic gelation
Molecular Medicine
Pharmaceutical Science
Drug Discovery
title_short Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
title_full Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
title_fullStr Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
title_full_unstemmed Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
title_sort Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
author Araújo, Diana
author_facet Araújo, Diana
Martins, Matilde
Concórdio-Reis, Patrícia
Roma-Rodrigues, Catarina
Morais, Maria
Alves, Vítor D.
Fernandes, Alexandra R.
Freitas, Filomena
author_role author
author2 Martins, Matilde
Concórdio-Reis, Patrícia
Roma-Rodrigues, Catarina
Morais, Maria
Alves, Vítor D.
Fernandes, Alexandra R.
Freitas, Filomena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
DCV - Departamento de Ciências da Vida
DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Araújo, Diana
Martins, Matilde
Concórdio-Reis, Patrícia
Roma-Rodrigues, Catarina
Morais, Maria
Alves, Vítor D.
Fernandes, Alexandra R.
Freitas, Filomena
dc.subject.por.fl_str_mv anti-inflammatory activity
biocompatibility
FucoPol
hydrogel membranes
ionotropic gelation
Molecular Medicine
Pharmaceutical Science
Drug Discovery
topic anti-inflammatory activity
biocompatibility
FucoPol
hydrogel membranes
ionotropic gelation
Molecular Medicine
Pharmaceutical Science
Drug Discovery
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-08T22:09:23Z
2023-07-11
2023-07-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/159722
url http://hdl.handle.net/10362/159722
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1424-8247
PURE: 75686880
https://doi.org/10.3390/ph16070991
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 23
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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