Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/159722 |
Resumo: | Publisher Copyright: © 2023 by the authors. |
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7160 |
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Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPolDesign, Characterization and Biological Propertiesanti-inflammatory activitybiocompatibilityFucoPolhydrogel membranesionotropic gelationMolecular MedicinePharmaceutical ScienceDrug DiscoveryPublisher Copyright: © 2023 by the authors.FucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe3+ as a crosslinking agent. This study evaluated the impact of Fe3+ and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe3+ concentration had a limited influence on the HMs’ strength, and varying the FucoPol concentration had a more significant effect. Three different FucoPol concentrations (1.0, 1.75 and 2.5 wt.%) were combined with Fe3+ (1.5 g/L), resulting in HMs with a water content above 97 wt.% and an Fe3+ content up to 0.16 wt.%. HMs with lower FucoPol content exhibited a denser porous microstructure as the polymer concentration increased. Moreover, the low polymer content HM presented the highest swelling ratio (22.3 ± 1.8 g/g) and a lower hardness value (32.4 ± 5.8 kPa). However, improved mechanical properties (221.9 ± 10.2 kPa) along with a decrease in the swelling ratio (11.9 ± 1.6 g/g) were obtained for HMs with a higher polymer content. Furthermore, all HMs were non-cytotoxic and revealed anti-inflammatory activity. The incorporation of FucoPol as a structuring agent and bioactive ingredient in the development of HMs opens up new possibilities for its use in tissue engineering, drug delivery and wound care management.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaDCV - Departamento de Ciências da VidaDCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNAraújo, DianaMartins, MatildeConcórdio-Reis, PatríciaRoma-Rodrigues, CatarinaMorais, MariaAlves, Vítor D.Fernandes, Alexandra R.Freitas, Filomena2023-11-08T22:09:23Z2023-07-112023-07-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article23application/pdfhttp://hdl.handle.net/10362/159722eng1424-8247PURE: 75686880https://doi.org/10.3390/ph16070991info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:10Zoai:run.unl.pt:10362/159722Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:40.557673Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol Design, Characterization and Biological Properties |
title |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol |
spellingShingle |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol Araújo, Diana anti-inflammatory activity biocompatibility FucoPol hydrogel membranes ionotropic gelation Molecular Medicine Pharmaceutical Science Drug Discovery |
title_short |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol |
title_full |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol |
title_fullStr |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol |
title_full_unstemmed |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol |
title_sort |
Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol |
author |
Araújo, Diana |
author_facet |
Araújo, Diana Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena |
author_role |
author |
author2 |
Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DQ - Departamento de Química DCV - Departamento de Ciências da Vida DCM - Departamento de Ciência dos Materiais CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N) RUN |
dc.contributor.author.fl_str_mv |
Araújo, Diana Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena |
dc.subject.por.fl_str_mv |
anti-inflammatory activity biocompatibility FucoPol hydrogel membranes ionotropic gelation Molecular Medicine Pharmaceutical Science Drug Discovery |
topic |
anti-inflammatory activity biocompatibility FucoPol hydrogel membranes ionotropic gelation Molecular Medicine Pharmaceutical Science Drug Discovery |
description |
Publisher Copyright: © 2023 by the authors. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-08T22:09:23Z 2023-07-11 2023-07-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/159722 |
url |
http://hdl.handle.net/10362/159722 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1424-8247 PURE: 75686880 https://doi.org/10.3390/ph16070991 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
23 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799138158857682944 |