Determination of tetracycline and its major degradation products by chemiluminescence

Detalhes bibliográficos
Autor(a) principal: Pena, Angelina
Data de Publicação: 2000
Outros Autores: Palilis, Leonidas P., Lino, Celeste M., Silveira, M. Irene, Calokerinos, Antony C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/5814
https://doi.org/10.1016/S0003-2670(99)00668-6
Resumo: A fast and simple flow injection chemiluminometric method for the determination of trace amounts of tetracycline (TC) and its major degradation products epitetracycline (ETC), epianhydrotetracycline (EATC) and anhydrotetracycline (ATC) based upon the action of potassium hexacyanoferrate(III) in alkaline solution has been developed. The analytes can be determined with 10[sigma] limits of quantification of 0.5 [mu]g for ETC, 2.0 [mu]g for TC, 0.01 [mu]g for EATC and 0.04 [mu]g for ATC. The sensitivity for TC is greatly improved by acidic degradation prior to the chemiluminescence (CL) measurement. The method developed allows measurement within the ranges of 0.040-2.0 [mu]g TC and ATC, 0.50-5.0 [mu]g ETC and 0.01-2.0 [mu]g EATC.
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spelling Determination of tetracycline and its major degradation products by chemiluminescenceChemiluminescenceTetracyclineEpitetracyclineAnhydrotetracyclineEpianhydrotetracyclineA fast and simple flow injection chemiluminometric method for the determination of trace amounts of tetracycline (TC) and its major degradation products epitetracycline (ETC), epianhydrotetracycline (EATC) and anhydrotetracycline (ATC) based upon the action of potassium hexacyanoferrate(III) in alkaline solution has been developed. The analytes can be determined with 10[sigma] limits of quantification of 0.5 [mu]g for ETC, 2.0 [mu]g for TC, 0.01 [mu]g for EATC and 0.04 [mu]g for ATC. The sensitivity for TC is greatly improved by acidic degradation prior to the chemiluminescence (CL) measurement. The method developed allows measurement within the ranges of 0.040-2.0 [mu]g TC and ATC, 0.50-5.0 [mu]g ETC and 0.01-2.0 [mu]g EATC.http://www.sciencedirect.com/science/article/B6TF4-3Y6Y3GW-7/1/1d12f8c9f3ebc4f46cb7a0dcec9baee42000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleaplication/PDFhttp://hdl.handle.net/10316/5814http://hdl.handle.net/10316/5814https://doi.org/10.1016/S0003-2670(99)00668-6engAnalytica Chimica Acta. 405:1-2 (2000) 51-56Pena, AngelinaPalilis, Leonidas P.Lino, Celeste M.Silveira, M. IreneCalokerinos, Antony C.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-10-28T10:20:55Zoai:estudogeral.uc.pt:10316/5814Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:19.177795Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Determination of tetracycline and its major degradation products by chemiluminescence
title Determination of tetracycline and its major degradation products by chemiluminescence
spellingShingle Determination of tetracycline and its major degradation products by chemiluminescence
Pena, Angelina
Chemiluminescence
Tetracycline
Epitetracycline
Anhydrotetracycline
Epianhydrotetracycline
title_short Determination of tetracycline and its major degradation products by chemiluminescence
title_full Determination of tetracycline and its major degradation products by chemiluminescence
title_fullStr Determination of tetracycline and its major degradation products by chemiluminescence
title_full_unstemmed Determination of tetracycline and its major degradation products by chemiluminescence
title_sort Determination of tetracycline and its major degradation products by chemiluminescence
author Pena, Angelina
author_facet Pena, Angelina
Palilis, Leonidas P.
Lino, Celeste M.
Silveira, M. Irene
Calokerinos, Antony C.
author_role author
author2 Palilis, Leonidas P.
Lino, Celeste M.
Silveira, M. Irene
Calokerinos, Antony C.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pena, Angelina
Palilis, Leonidas P.
Lino, Celeste M.
Silveira, M. Irene
Calokerinos, Antony C.
dc.subject.por.fl_str_mv Chemiluminescence
Tetracycline
Epitetracycline
Anhydrotetracycline
Epianhydrotetracycline
topic Chemiluminescence
Tetracycline
Epitetracycline
Anhydrotetracycline
Epianhydrotetracycline
description A fast and simple flow injection chemiluminometric method for the determination of trace amounts of tetracycline (TC) and its major degradation products epitetracycline (ETC), epianhydrotetracycline (EATC) and anhydrotetracycline (ATC) based upon the action of potassium hexacyanoferrate(III) in alkaline solution has been developed. The analytes can be determined with 10[sigma] limits of quantification of 0.5 [mu]g for ETC, 2.0 [mu]g for TC, 0.01 [mu]g for EATC and 0.04 [mu]g for ATC. The sensitivity for TC is greatly improved by acidic degradation prior to the chemiluminescence (CL) measurement. The method developed allows measurement within the ranges of 0.040-2.0 [mu]g TC and ATC, 0.50-5.0 [mu]g ETC and 0.01-2.0 [mu]g EATC.
publishDate 2000
dc.date.none.fl_str_mv 2000
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/5814
http://hdl.handle.net/10316/5814
https://doi.org/10.1016/S0003-2670(99)00668-6
url http://hdl.handle.net/10316/5814
https://doi.org/10.1016/S0003-2670(99)00668-6
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Analytica Chimica Acta. 405:1-2 (2000) 51-56
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv aplication/PDF
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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