Q&A: Who needs a centrosome?

Detalhes bibliográficos
Autor(a) principal: Bettencourt-Dias, Mónica
Data de Publicação: 2013
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/428
Resumo: The centrosome has several functions. The central one is as the major microtubule organizing center (MTOC) in proliferating animal cells: thus, it helps to organize the microtubules that form the mitotic spindle in dividing cells, and orchestrate a wide variety of cellular processes, including cell motility, signaling, adhesion, coordination of protein trafficking by the microtubule cytoskeleton and the acquisition of polarity. The centrosome has crucial links to the nucleus, the Golgi, cell to cell junctions and acto-myosin cytoskeleton that are very important in positioning it and thus shaping the microtubule cytoskeleton in relation to the cell and the organism (reviewed in [1]). The role of the centrosome in organizing cellular microtubules can differ from cell to cell and be regulated differently in different phases of the life of a cell.
id RCAP_bad1c0ed11204b0c364ce395f01f63ed
oai_identifier_str oai:arca.igc.gulbenkian.pt:10400.7/428
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Q&A: Who needs a centrosome?CentrosomeThe centrosome has several functions. The central one is as the major microtubule organizing center (MTOC) in proliferating animal cells: thus, it helps to organize the microtubules that form the mitotic spindle in dividing cells, and orchestrate a wide variety of cellular processes, including cell motility, signaling, adhesion, coordination of protein trafficking by the microtubule cytoskeleton and the acquisition of polarity. The centrosome has crucial links to the nucleus, the Golgi, cell to cell junctions and acto-myosin cytoskeleton that are very important in positioning it and thus shaping the microtubule cytoskeleton in relation to the cell and the organism (reviewed in [1]). The role of the centrosome in organizing cellular microtubules can differ from cell to cell and be regulated differently in different phases of the life of a cell.Laboratório Associado de Oeiras, EMBO Installation Grant: (co-funded by FCT and Instituto Gulbenkian de Ciência), FCT, Instituto Gulbenkian de Ciência.BioMed CentralARCABettencourt-Dias, Mónica2015-10-22T15:12:14Z2013-04-112013-04-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/428engBettencourt-Dias M: Q&A: Who needs a centrosome?. BMC Biology 2013 11:28.10.1186/1741-7007-11-28info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:49Zoai:arca.igc.gulbenkian.pt:10400.7/428Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:43.197731Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Q&A: Who needs a centrosome?
title Q&A: Who needs a centrosome?
spellingShingle Q&A: Who needs a centrosome?
Bettencourt-Dias, Mónica
Centrosome
title_short Q&A: Who needs a centrosome?
title_full Q&A: Who needs a centrosome?
title_fullStr Q&A: Who needs a centrosome?
title_full_unstemmed Q&A: Who needs a centrosome?
title_sort Q&A: Who needs a centrosome?
author Bettencourt-Dias, Mónica
author_facet Bettencourt-Dias, Mónica
author_role author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Bettencourt-Dias, Mónica
dc.subject.por.fl_str_mv Centrosome
topic Centrosome
description The centrosome has several functions. The central one is as the major microtubule organizing center (MTOC) in proliferating animal cells: thus, it helps to organize the microtubules that form the mitotic spindle in dividing cells, and orchestrate a wide variety of cellular processes, including cell motility, signaling, adhesion, coordination of protein trafficking by the microtubule cytoskeleton and the acquisition of polarity. The centrosome has crucial links to the nucleus, the Golgi, cell to cell junctions and acto-myosin cytoskeleton that are very important in positioning it and thus shaping the microtubule cytoskeleton in relation to the cell and the organism (reviewed in [1]). The role of the centrosome in organizing cellular microtubules can differ from cell to cell and be regulated differently in different phases of the life of a cell.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-11
2013-04-11T00:00:00Z
2015-10-22T15:12:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/428
url http://hdl.handle.net/10400.7/428
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bettencourt-Dias M: Q&A: Who needs a centrosome?. BMC Biology 2013 11:28.
10.1186/1741-7007-11-28
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799130572898959360

Registros relacionados