ATP13A2 and alpha-synuclein: a metal taste in autophagy

Detalhes bibliográficos
Autor(a) principal: da Fonseca, Tomás Lopes
Data de Publicação: 2014
Outros Autores: Outeiro, Tiago
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50239
Resumo: © The Korean Society for Brain and Neural Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling ATP13A2 and alpha-synuclein: a metal taste in autophagyATP13A2Parkinson's DiseaseAlpha-synucleinAutophagyMetal homeostasis© The Korean Society for Brain and Neural Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.Parkinson's Disease (PD) is a complex and multifactorial disorder of both idiopathic and genetic origin. Thus far, more than 20 genes have been linked to familial forms of PD. Two of these genes encode for ATP13A2 and alpha-synuclein (asyn), proteins that seem to be members of a common network in both physiological and disease conditions. Thus, two different hypotheses have emerged supporting a role of ATP13A2 and asyn in metal homeostasis or in autophagy. Interestingly, an appealing theory might combine these two cellular pathways. Here we review the novel findings in the interaction between these two proteins and debate the exciting roads still ahead.TLF is supported by Fundação para a Ciência e Tecnologia (SFRH/BD/74881/2010). TFO is supported by the DFG Center for Nanoscale Microscopy and Molecular Physiology of the BrainKorean Society for Brain and Neural Sciences & The Korean Society for Neurodegenerative DiseaseRepositório da Universidade de Lisboada Fonseca, Tomás LopesOuteiro, Tiago2021-12-02T12:35:02Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50239engExp Neurobiol. 2014 Dec;23(4):314-32310.5607/en.2014.23.4.3141226-2560info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:14Zoai:repositorio.ul.pt:10451/50239Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:40.931Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv ATP13A2 and alpha-synuclein: a metal taste in autophagy
title ATP13A2 and alpha-synuclein: a metal taste in autophagy
spellingShingle ATP13A2 and alpha-synuclein: a metal taste in autophagy
da Fonseca, Tomás Lopes
ATP13A2
Parkinson's Disease
Alpha-synuclein
Autophagy
Metal homeostasis
title_short ATP13A2 and alpha-synuclein: a metal taste in autophagy
title_full ATP13A2 and alpha-synuclein: a metal taste in autophagy
title_fullStr ATP13A2 and alpha-synuclein: a metal taste in autophagy
title_full_unstemmed ATP13A2 and alpha-synuclein: a metal taste in autophagy
title_sort ATP13A2 and alpha-synuclein: a metal taste in autophagy
author da Fonseca, Tomás Lopes
author_facet da Fonseca, Tomás Lopes
Outeiro, Tiago
author_role author
author2 Outeiro, Tiago
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv da Fonseca, Tomás Lopes
Outeiro, Tiago
dc.subject.por.fl_str_mv ATP13A2
Parkinson's Disease
Alpha-synuclein
Autophagy
Metal homeostasis
topic ATP13A2
Parkinson's Disease
Alpha-synuclein
Autophagy
Metal homeostasis
description © The Korean Society for Brain and Neural Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2021-12-02T12:35:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50239
url http://hdl.handle.net/10451/50239
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Exp Neurobiol. 2014 Dec;23(4):314-323
10.5607/en.2014.23.4.314
1226-2560
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Korean Society for Brain and Neural Sciences & The Korean Society for Neurodegenerative Disease
publisher.none.fl_str_mv Korean Society for Brain and Neural Sciences & The Korean Society for Neurodegenerative Disease
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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