Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus

Detalhes bibliográficos
Autor(a) principal: Costa, Sofia Santos
Data de Publicação: 2021
Outros Autores: Ferreira, Carolina, Ribeiro, Rute, Fessler, Andrea T., Schink, Anne-Kathrin, Kadlec, Kristina, Kaspar, Heike, Amaro, Ana, Albuquerque, Teresa, Abrantes, Patricia, Morais, Catarina, Pomba, C., Schwarz, Stefan, Couto, Isabel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/22537
Resumo: Research Areas: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
id RCAP_bcd3b3daf6b02501d36c8739003b928f
oai_identifier_str oai:repositorio.ul.pt:10400.5/22537
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureusStaphylococcus aureusEpidemiological cutoff valueApramycinFlorfenicolResearch Areas: Infectious Diseases ; Microbiology ; Pharmacology & PharmacyApramycin and florfenicol are two antimicrobial agents exclusively used in veterinary medicine. Resistance determinants to these antimicrobial agents have been described in several staphylococci, yet no inhibition zone-based epidemiological cutoff (ECOFF) values are available to detect populations harboring resistance mechanisms. In this study, we propose disk diffusion inhibition zone ECOFF values of Staphylococcus aureus for apramycin and florfenicol. The susceptibility to apramycin and florfenicol was evaluated by disk diffusion of five S. aureus collections, comprising 352 isolates of animal (n = 265) and human (n = 87) origin. The aggregated distributions of inhibition zone diameters were analyzed by the normalized resistance interpretation method to obtain normalized wild-type (WT) population distributions and corresponding ECOFF values. The putative WT populations of S. aureus were characterized by an inhibition zone ‡15 mm (ECOFF = 15 mm) for apramycin and ‡21 mm for florfenicol (ECOFF = 21 mm). Five nonwild-type (NWT) isolates were detected for apramycin, all without inhibition zone and harboring the apmA gene, whereas five NWT isolates were identified for florfenicol, all carrying the fexA gene. The proposed ECOFF values for apramycin and florfenicol may be a valuable tool in future antimicrobial resistance monitoring and surveillance studies to identify S. aureus NWT populations toward these antimicrobial agents.Mary Ann LiebertRepositório da Universidade de LisboaCosta, Sofia SantosFerreira, CarolinaRibeiro, RuteFessler, Andrea T.Schink, Anne-KathrinKadlec, KristinaKaspar, HeikeAmaro, AnaAlbuquerque, TeresaAbrantes, PatriciaMorais, CatarinaPomba, C.Schwarz, StefanCouto, Isabel2021-11-09T15:14:48Z2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22537engCosta SS, Ferreira C, Ribeiro R, Fessler AT, Schink AK, Kadlec K, Kaspar H, Amaro A, Albuquerque T, Pomba C, et al. 2021. Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus. Microbial Drug Resistance, 00(00). DOI:10.1089/mdr.2020.04021076-629410.1089/mdr.2020.04021931-8448info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-11-20T18:36:10Zoai:repositorio.ul.pt:10400.5/22537Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-11-20T18:36:10Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
title Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
spellingShingle Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
Costa, Sofia Santos
Staphylococcus aureus
Epidemiological cutoff value
Apramycin
Florfenicol
title_short Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
title_full Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
title_fullStr Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
title_full_unstemmed Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
title_sort Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
author Costa, Sofia Santos
author_facet Costa, Sofia Santos
Ferreira, Carolina
Ribeiro, Rute
Fessler, Andrea T.
Schink, Anne-Kathrin
Kadlec, Kristina
Kaspar, Heike
Amaro, Ana
Albuquerque, Teresa
Abrantes, Patricia
Morais, Catarina
Pomba, C.
Schwarz, Stefan
Couto, Isabel
author_role author
author2 Ferreira, Carolina
Ribeiro, Rute
Fessler, Andrea T.
Schink, Anne-Kathrin
Kadlec, Kristina
Kaspar, Heike
Amaro, Ana
Albuquerque, Teresa
Abrantes, Patricia
Morais, Catarina
Pomba, C.
Schwarz, Stefan
Couto, Isabel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Costa, Sofia Santos
Ferreira, Carolina
Ribeiro, Rute
Fessler, Andrea T.
Schink, Anne-Kathrin
Kadlec, Kristina
Kaspar, Heike
Amaro, Ana
Albuquerque, Teresa
Abrantes, Patricia
Morais, Catarina
Pomba, C.
Schwarz, Stefan
Couto, Isabel
dc.subject.por.fl_str_mv Staphylococcus aureus
Epidemiological cutoff value
Apramycin
Florfenicol
topic Staphylococcus aureus
Epidemiological cutoff value
Apramycin
Florfenicol
description Research Areas: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy
publishDate 2021
dc.date.none.fl_str_mv 2021-11-09T15:14:48Z
2021-05
2021-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/22537
url http://hdl.handle.net/10400.5/22537
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Costa SS, Ferreira C, Ribeiro R, Fessler AT, Schink AK, Kadlec K, Kaspar H, Amaro A, Albuquerque T, Pomba C, et al. 2021. Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus. Microbial Drug Resistance, 00(00). DOI:10.1089/mdr.2020.0402
1076-6294
10.1089/mdr.2020.0402
1931-8448
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817549320800436224