Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.5/22537 |
Resumo: | Research Areas: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy |
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7160 |
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Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureusStaphylococcus aureusEpidemiological cutoff valueApramycinFlorfenicolResearch Areas: Infectious Diseases ; Microbiology ; Pharmacology & PharmacyApramycin and florfenicol are two antimicrobial agents exclusively used in veterinary medicine. Resistance determinants to these antimicrobial agents have been described in several staphylococci, yet no inhibition zone-based epidemiological cutoff (ECOFF) values are available to detect populations harboring resistance mechanisms. In this study, we propose disk diffusion inhibition zone ECOFF values of Staphylococcus aureus for apramycin and florfenicol. The susceptibility to apramycin and florfenicol was evaluated by disk diffusion of five S. aureus collections, comprising 352 isolates of animal (n = 265) and human (n = 87) origin. The aggregated distributions of inhibition zone diameters were analyzed by the normalized resistance interpretation method to obtain normalized wild-type (WT) population distributions and corresponding ECOFF values. The putative WT populations of S. aureus were characterized by an inhibition zone ‡15 mm (ECOFF = 15 mm) for apramycin and ‡21 mm for florfenicol (ECOFF = 21 mm). Five nonwild-type (NWT) isolates were detected for apramycin, all without inhibition zone and harboring the apmA gene, whereas five NWT isolates were identified for florfenicol, all carrying the fexA gene. The proposed ECOFF values for apramycin and florfenicol may be a valuable tool in future antimicrobial resistance monitoring and surveillance studies to identify S. aureus NWT populations toward these antimicrobial agents.Mary Ann LiebertRepositório da Universidade de LisboaCosta, Sofia SantosFerreira, CarolinaRibeiro, RuteFessler, Andrea T.Schink, Anne-KathrinKadlec, KristinaKaspar, HeikeAmaro, AnaAlbuquerque, TeresaAbrantes, PatriciaMorais, CatarinaPomba, C.Schwarz, StefanCouto, Isabel2021-11-09T15:14:48Z2021-052021-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/22537engCosta SS, Ferreira C, Ribeiro R, Fessler AT, Schink AK, Kadlec K, Kaspar H, Amaro A, Albuquerque T, Pomba C, et al. 2021. Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus. Microbial Drug Resistance, 00(00). DOI:10.1089/mdr.2020.04021076-629410.1089/mdr.2020.04021931-8448info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:52:03Zoai:www.repository.utl.pt:10400.5/22537Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:06:56.493017Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
title |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
spellingShingle |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus Costa, Sofia Santos Staphylococcus aureus Epidemiological cutoff value Apramycin Florfenicol |
title_short |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
title_full |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
title_fullStr |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
title_full_unstemmed |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
title_sort |
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus |
author |
Costa, Sofia Santos |
author_facet |
Costa, Sofia Santos Ferreira, Carolina Ribeiro, Rute Fessler, Andrea T. Schink, Anne-Kathrin Kadlec, Kristina Kaspar, Heike Amaro, Ana Albuquerque, Teresa Abrantes, Patricia Morais, Catarina Pomba, C. Schwarz, Stefan Couto, Isabel |
author_role |
author |
author2 |
Ferreira, Carolina Ribeiro, Rute Fessler, Andrea T. Schink, Anne-Kathrin Kadlec, Kristina Kaspar, Heike Amaro, Ana Albuquerque, Teresa Abrantes, Patricia Morais, Catarina Pomba, C. Schwarz, Stefan Couto, Isabel |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Costa, Sofia Santos Ferreira, Carolina Ribeiro, Rute Fessler, Andrea T. Schink, Anne-Kathrin Kadlec, Kristina Kaspar, Heike Amaro, Ana Albuquerque, Teresa Abrantes, Patricia Morais, Catarina Pomba, C. Schwarz, Stefan Couto, Isabel |
dc.subject.por.fl_str_mv |
Staphylococcus aureus Epidemiological cutoff value Apramycin Florfenicol |
topic |
Staphylococcus aureus Epidemiological cutoff value Apramycin Florfenicol |
description |
Research Areas: Infectious Diseases ; Microbiology ; Pharmacology & Pharmacy |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-09T15:14:48Z 2021-05 2021-05-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.5/22537 |
url |
http://hdl.handle.net/10400.5/22537 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Costa SS, Ferreira C, Ribeiro R, Fessler AT, Schink AK, Kadlec K, Kaspar H, Amaro A, Albuquerque T, Pomba C, et al. 2021. Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 30 μg Disks Applicable to Staphylococcus aureus. Microbial Drug Resistance, 00(00). DOI:10.1089/mdr.2020.0402 1076-6294 10.1089/mdr.2020.0402 1931-8448 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
publisher.none.fl_str_mv |
Mary Ann Liebert |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1817552648126070784 |