Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release

Detalhes bibliográficos
Autor(a) principal: Lago, Beatriz
Data de Publicação: 2023
Outros Autores: Brito, Miguel, Almeida, Cristina M. M., Ferreira, Isabel, Baptista, Ana Catarina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154939
Resumo: Funding Information: This work was also supported by ERC-CoG-2014, CapTherPV, 647596. Publisher Copyright: © 2023 by the authors.
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spelling Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Releasecellulose acetateconducting polymerscontrolled drug release systemelectrical stimulielectrospinningPEDOTpolypyrroleChemical Engineering(all)Materials Science(all)Funding Information: This work was also supported by ERC-CoG-2014, CapTherPV, 647596. Publisher Copyright: © 2023 by the authors.Controlled drug release via electrical stimulation from drug-impregnated fibres was studied using electrospun cellulose acetate (CA) membranes and encapsulated ibuprofen (IBU). This research outlines the influence of polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT)-functionalised CA membranes and their suitability for dermal electronic-controlled drug release. Micro Raman analysis confirmed polymer functionalisation of CA membranes and drug incorporation. Scanning electron microscopy (SEM) images evidenced the presence of PPy and PEDOT coatings. The kinetic of drug release was analysed, and the passive and active release was compared. In the proposed systems, the drug release is controlled by very low electrical potentials. A potential of −0.3 V applied to membranes showed the ibuprofen retention, and a positive potential of +0.3 V, +0.5 V, or +0.8 V, depending on the conductive polymer and membrane configuration, enhanced the drug release. A small adhesive patch was constructed to validate this system for cutaneous application and verified an “ON/OFF” ibuprofen release pattern from membranes.DCM - Departamento de Ciência dos MateriaisCENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)RUNLago, BeatrizBrito, MiguelAlmeida, Cristina M. M.Ferreira, IsabelBaptista, Ana Catarina2023-07-06T22:17:32Z2023-04-272023-04-27T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article18application/pdfhttp://hdl.handle.net/10362/154939eng2079-4991PURE: 65374145https://doi.org/10.3390/nano13091493info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:26Zoai:run.unl.pt:10362/154939Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:51.754468Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
title Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
spellingShingle Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
Lago, Beatriz
cellulose acetate
conducting polymers
controlled drug release system
electrical stimuli
electrospinning
PEDOT
polypyrrole
Chemical Engineering(all)
Materials Science(all)
title_short Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
title_full Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
title_fullStr Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
title_full_unstemmed Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
title_sort Functionalisation of Electrospun Cellulose Acetate Membranes with PEDOT and PPy for Electronic Controlled Drug Release
author Lago, Beatriz
author_facet Lago, Beatriz
Brito, Miguel
Almeida, Cristina M. M.
Ferreira, Isabel
Baptista, Ana Catarina
author_role author
author2 Brito, Miguel
Almeida, Cristina M. M.
Ferreira, Isabel
Baptista, Ana Catarina
author2_role author
author
author
author
dc.contributor.none.fl_str_mv DCM - Departamento de Ciência dos Materiais
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
RUN
dc.contributor.author.fl_str_mv Lago, Beatriz
Brito, Miguel
Almeida, Cristina M. M.
Ferreira, Isabel
Baptista, Ana Catarina
dc.subject.por.fl_str_mv cellulose acetate
conducting polymers
controlled drug release system
electrical stimuli
electrospinning
PEDOT
polypyrrole
Chemical Engineering(all)
Materials Science(all)
topic cellulose acetate
conducting polymers
controlled drug release system
electrical stimuli
electrospinning
PEDOT
polypyrrole
Chemical Engineering(all)
Materials Science(all)
description Funding Information: This work was also supported by ERC-CoG-2014, CapTherPV, 647596. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-06T22:17:32Z
2023-04-27
2023-04-27T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154939
url http://hdl.handle.net/10362/154939
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2079-4991
PURE: 65374145
https://doi.org/10.3390/nano13091493
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 18
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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