Acute Liver Failure due to Trazodone and Diazepam
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007 |
Resumo: | Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications. |
id |
RCAP_bd7458a56d7aac4f88bc237314ebd7a4 |
---|---|
oai_identifier_str |
oai:scielo:S2341-45452017000100007 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Acute Liver Failure due to Trazodone and DiazepamAntidepressive agentsDiazepamLiver failure, acute/chemically inducedTrazodoneMost antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications.Sociedade Portuguesa de Gastrenterologia2017-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007GE-Portuguese Journal of Gastroenterology v.24 n.1 2017reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007Carvalhana,SofiaOliveira,AnaFerreira,PedroResende,MargaridaPerdigoto,RuiBarroso,Eduardoinfo:eu-repo/semantics/openAccess2024-02-06T17:33:44Zoai:scielo:S2341-45452017000100007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:35:59.552873Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Acute Liver Failure due to Trazodone and Diazepam |
title |
Acute Liver Failure due to Trazodone and Diazepam |
spellingShingle |
Acute Liver Failure due to Trazodone and Diazepam Carvalhana,Sofia Antidepressive agents Diazepam Liver failure, acute/chemically induced Trazodone |
title_short |
Acute Liver Failure due to Trazodone and Diazepam |
title_full |
Acute Liver Failure due to Trazodone and Diazepam |
title_fullStr |
Acute Liver Failure due to Trazodone and Diazepam |
title_full_unstemmed |
Acute Liver Failure due to Trazodone and Diazepam |
title_sort |
Acute Liver Failure due to Trazodone and Diazepam |
author |
Carvalhana,Sofia |
author_facet |
Carvalhana,Sofia Oliveira,Ana Ferreira,Pedro Resende,Margarida Perdigoto,Rui Barroso,Eduardo |
author_role |
author |
author2 |
Oliveira,Ana Ferreira,Pedro Resende,Margarida Perdigoto,Rui Barroso,Eduardo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carvalhana,Sofia Oliveira,Ana Ferreira,Pedro Resende,Margarida Perdigoto,Rui Barroso,Eduardo |
dc.subject.por.fl_str_mv |
Antidepressive agents Diazepam Liver failure, acute/chemically induced Trazodone |
topic |
Antidepressive agents Diazepam Liver failure, acute/chemically induced Trazodone |
description |
Most antidepressant agents have the potential to cause liver injury, even at therapeutic doses. Nevertheless, drug-induced liver injury (DILI) from antidepressant agents is a rare event. There is no way to prevent idiopathic DILI, but the severity of the reaction may be minimized with prompt recognition and early withdrawal of the agent. We describe a rare case of a 63-year-old man presenting with acute liver failure after 3 months of trazodone and diazepam administration at normal therapeutic doses, requiring liver transplantation. This report should increase physicians awareness of this complication and call attention to the regular monitoring of liver tests in patients taking trazodone, in order to prevent life-threatening complications. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-02-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S2341-45452017000100007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Gastrenterologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Gastrenterologia |
dc.source.none.fl_str_mv |
GE-Portuguese Journal of Gastroenterology v.24 n.1 2017 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799137412335534080 |