Implementation of effect biomarkers in human biomonitoring studies
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Outros |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/151019 |
Resumo: | Funding Information: This work was supported by the European Union's Horizon 2020 research and innovation program projects HBM4EU [grant number 733032 ]. Authors acknowledge the editorial assistance of Richard Davies. Publisher Copyright: © 2023 The Author(s) |
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Implementation of effect biomarkers in human biomonitoring studiesA systematic approach synergizing toxicological and epidemiological knowledgeBiomarkersEffect biomarkersEnvironmental chemicalsHBM4EUHuman biomonitoring programsOccupational chemicalsPublic Health, Environmental and Occupational HealthSDG 3 - Good Health and Well-beingFunding Information: This work was supported by the European Union's Horizon 2020 research and innovation program projects HBM4EU [grant number 733032 ]. Authors acknowledge the editorial assistance of Richard Davies. Publisher Copyright: © 2023 The Author(s)Human biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are suspected to contribute to adverse health outcomes such as reproductive, neurological, and metabolic disorders, among other developmental and chronic impairments. One of the objectives of the H2020 European Human Biomonitoring Initiative (HBM4EU) was the development of informative effect biomarkers for application in a more systematic and harmonized way in large-scale European HBM studies. The inclusion of effect biomarkers would complement exposure data with mechanistically-based information on early and late adverse effects. For this purpose, a stepwise strategy was developed to identify and implement a panel of validated effect biomarkers in European HBM studies. This work offers an overview of the complete procedure followed, from comprehensive literature search strategies, selection of criteria for effect biomarkers and their classification and prioritization, based on toxicological data and adverse outcomes, to pilot studies for their analytical, physiological, and epidemiological validation. We present the example of one study that demonstrated the mediating role of the effect biomarker status of brain-derived neurotrophic factor BDNF in the longitudinal association between infant bisphenol A (BPA) exposure and behavioral function in adolescence. A panel of effect biomarkers has been implemented in the HBM4EU Aligned Studies as main outcomes, including traditional oxidative stress, reproductive, and thyroid hormone biomarkers. Novel biomarkers of effect, such as DNA methylation status of BDNF and kisspeptin (KISS) genes were also evaluated as molecular markers of neurological and reproductive health, respectively. A panel of effect biomarkers has also been applied in HBM4EU occupational studies, such as micronucleus analysis in lymphocytes and reticulocytes, whole blood comet assay, and malondialdehyde, 8-oxo-2′-deoxyguanosine and untargeted metabolomic profile in urine, to investigate, for example, biological changes in response to hexavalent chromium Cr(VI) exposure. The use of effect biomarkers in HBM4EU has demonstrated their ability to detect early biological effects of chemical exposure and to identify subgroups that are at higher risk. The roadmap developed in HBM4EU confirms the utility of effect biomarkers, and support one of the main objectives of HBM research, which is to link exposure biomarkers to mechanistically validated effect and susceptibility biomarkers in order to better understand the public health implications of human exposure to environmental chemicals.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNRodríguez-Carrillo, AndreaMustieles, VicenteSalamanca-Fernández, ElenaOlivas-Martínez, AliciaSuárez, BeatrizBajard, LolaBaken, KirstenBlaha, LudekBonefeld-Jørgensen, Eva CecilieCouderq, StephanD'Cruz, Shereen CynthiaFini, Jean BaptisteGovarts, EvaGundacker, ClaudiaHernández, Antonio F.Lacasaña, MarinaLaguzzi, FedericaLinderman, BirgitteLong, ManhaiLouro, HenriquetaNeophytou, ChristianaOberemn, AxelRemy, SylvieRosenmai, Anna KjerstineSaber, Anne ThoustrupSchoeters, GreetSilva, Maria JoaoSmagulova, FatimaUhl, MariaVinggaard, Anne MarieVogel, UllaWielsøe, MariaOlea, NicolásFernández, Mariana F.2023-03-21T22:27:52Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/151019eng1438-4639PURE: 56513925https://doi.org/10.1016/j.ijheh.2023.114140info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:10:24Zoai:run.unl.pt:10362/151019Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:10:24Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Implementation of effect biomarkers in human biomonitoring studies A systematic approach synergizing toxicological and epidemiological knowledge |
| title |
Implementation of effect biomarkers in human biomonitoring studies |
| spellingShingle |
Implementation of effect biomarkers in human biomonitoring studies Rodríguez-Carrillo, Andrea Biomarkers Effect biomarkers Environmental chemicals HBM4EU Human biomonitoring programs Occupational chemicals Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
| title_short |
Implementation of effect biomarkers in human biomonitoring studies |
| title_full |
Implementation of effect biomarkers in human biomonitoring studies |
| title_fullStr |
Implementation of effect biomarkers in human biomonitoring studies |
| title_full_unstemmed |
Implementation of effect biomarkers in human biomonitoring studies |
| title_sort |
Implementation of effect biomarkers in human biomonitoring studies |
| author |
Rodríguez-Carrillo, Andrea |
| author_facet |
Rodríguez-Carrillo, Andrea Mustieles, Vicente Salamanca-Fernández, Elena Olivas-Martínez, Alicia Suárez, Beatriz Bajard, Lola Baken, Kirsten Blaha, Ludek Bonefeld-Jørgensen, Eva Cecilie Couderq, Stephan D'Cruz, Shereen Cynthia Fini, Jean Baptiste Govarts, Eva Gundacker, Claudia Hernández, Antonio F. Lacasaña, Marina Laguzzi, Federica Linderman, Birgitte Long, Manhai Louro, Henriqueta Neophytou, Christiana Oberemn, Axel Remy, Sylvie Rosenmai, Anna Kjerstine Saber, Anne Thoustrup Schoeters, Greet Silva, Maria Joao Smagulova, Fatima Uhl, Maria Vinggaard, Anne Marie Vogel, Ulla Wielsøe, Maria Olea, Nicolás Fernández, Mariana F. |
| author_role |
author |
| author2 |
Mustieles, Vicente Salamanca-Fernández, Elena Olivas-Martínez, Alicia Suárez, Beatriz Bajard, Lola Baken, Kirsten Blaha, Ludek Bonefeld-Jørgensen, Eva Cecilie Couderq, Stephan D'Cruz, Shereen Cynthia Fini, Jean Baptiste Govarts, Eva Gundacker, Claudia Hernández, Antonio F. Lacasaña, Marina Laguzzi, Federica Linderman, Birgitte Long, Manhai Louro, Henriqueta Neophytou, Christiana Oberemn, Axel Remy, Sylvie Rosenmai, Anna Kjerstine Saber, Anne Thoustrup Schoeters, Greet Silva, Maria Joao Smagulova, Fatima Uhl, Maria Vinggaard, Anne Marie Vogel, Ulla Wielsøe, Maria Olea, Nicolás Fernández, Mariana F. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Rodríguez-Carrillo, Andrea Mustieles, Vicente Salamanca-Fernández, Elena Olivas-Martínez, Alicia Suárez, Beatriz Bajard, Lola Baken, Kirsten Blaha, Ludek Bonefeld-Jørgensen, Eva Cecilie Couderq, Stephan D'Cruz, Shereen Cynthia Fini, Jean Baptiste Govarts, Eva Gundacker, Claudia Hernández, Antonio F. Lacasaña, Marina Laguzzi, Federica Linderman, Birgitte Long, Manhai Louro, Henriqueta Neophytou, Christiana Oberemn, Axel Remy, Sylvie Rosenmai, Anna Kjerstine Saber, Anne Thoustrup Schoeters, Greet Silva, Maria Joao Smagulova, Fatima Uhl, Maria Vinggaard, Anne Marie Vogel, Ulla Wielsøe, Maria Olea, Nicolás Fernández, Mariana F. |
| dc.subject.por.fl_str_mv |
Biomarkers Effect biomarkers Environmental chemicals HBM4EU Human biomonitoring programs Occupational chemicals Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
| topic |
Biomarkers Effect biomarkers Environmental chemicals HBM4EU Human biomonitoring programs Occupational chemicals Public Health, Environmental and Occupational Health SDG 3 - Good Health and Well-being |
| description |
Funding Information: This work was supported by the European Union's Horizon 2020 research and innovation program projects HBM4EU [grant number 733032 ]. Authors acknowledge the editorial assistance of Richard Davies. Publisher Copyright: © 2023 The Author(s) |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-03-21T22:27:52Z 2023-04 2023-04-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/other |
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other |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/151019 |
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http://hdl.handle.net/10362/151019 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1438-4639 PURE: 56513925 https://doi.org/10.1016/j.ijheh.2023.114140 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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