Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/135676 |
Resumo: | Funding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responsesSDG 3 - Good Health and Well-beingFunding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46).Neutrophils are prominent immune components of tumors, having either anti-tumor (N1) or pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low density neutrophils (LDN), functionally mirror those N1 and N2 cells, respectively. LDN are rare in non-pathological conditions, but frequent in cancer, exhibiting a pro-tumor phenotype. These findings have been mainly demonstrated in animal models, thus proper validation in humans is still imperative. Here, we observed that LDN were increased in the blood of breast cancer (BC) patients, particularly with metastatic disease. Within the population of non-metastatic patients, LDN were more prevalent in patients with poor response to neoadjuvant chemotherapy than patients with a good response. The higher incidence of LDN in BC patients with severe disease or resistance to treatment can be explained by their pro-tumor/immunosuppressive characteristics. Moreover, the percentage of LDN in BC patients' blood was negatively correlated with activated cytotoxic T lymphocytes and positively correlated with immunosuppressive regulatory T cells. The ability of LDN to spoil anti-tumor immune responses was further demonstrated ex vivo. Hence, this study reveals the potential of LDN as a biomarker of BC response to treatment and opens new avenues for developing new immunotherapies.iNOVA4Health - pólo NMSCentro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSaraiva, Diana PCorreia, Bruna FSalvador, Rutede Sousa, NídiaJacinto, AntónioBraga, SofiaCabral, M Guadalupe2022-04-01T15:38:41Z2021-11-232021-11-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/135676eng1949-2553PURE: 42844165https://doi.org/10.18632/oncotarget.28135info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:14:01Zoai:run.unl.pt:10362/135676Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:48:29.185697Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
title |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
spellingShingle |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses Saraiva, Diana P SDG 3 - Good Health and Well-being |
title_short |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
title_full |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
title_fullStr |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
title_full_unstemmed |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
title_sort |
Circulating low density neutrophils of breast cancer patients are associated with their worse prognosis due to the impairment of T cell responses |
author |
Saraiva, Diana P |
author_facet |
Saraiva, Diana P Correia, Bruna F Salvador, Rute de Sousa, Nídia Jacinto, António Braga, Sofia Cabral, M Guadalupe |
author_role |
author |
author2 |
Correia, Bruna F Salvador, Rute de Sousa, Nídia Jacinto, António Braga, Sofia Cabral, M Guadalupe |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
iNOVA4Health - pólo NMS Centro de Estudos de Doenças Crónicas (CEDOC) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Saraiva, Diana P Correia, Bruna F Salvador, Rute de Sousa, Nídia Jacinto, António Braga, Sofia Cabral, M Guadalupe |
dc.subject.por.fl_str_mv |
SDG 3 - Good Health and Well-being |
topic |
SDG 3 - Good Health and Well-being |
description |
Funding: This work was supported by Liga Portuguesa Contra o Cancro; Fundação para a Ciência e Tecnologia (PD/BD/114023/2015, SFRH/BD/148422/2019 and 2021.08031.BD); and iNOVA4Health (UIDB/04462/2020 and DAI/2019/46). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-11-23 2021-11-23T00:00:00Z 2022-04-01T15:38:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/135676 |
url |
http://hdl.handle.net/10362/135676 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1949-2553 PURE: 42844165 https://doi.org/10.18632/oncotarget.28135 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799138086184026112 |