Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient

Detalhes bibliográficos
Autor(a) principal: Costa-Balogh, Fátima O.
Data de Publicação: 2005
Outros Autores: Åberg, Christoffer, Sousa, João J. S., Sparr, Emma
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/10431
https://doi.org/10.1021/la051947n
Resumo: In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.
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spelling Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic GradientIn this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.American Chemical Society2005-11-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/10431http://hdl.handle.net/10316/10431https://doi.org/10.1021/la051947nengLangmuir. 21:23 (2005) 10307-103100743-7463Costa-Balogh, Fátima O.Åberg, ChristofferSousa, João J. S.Sparr, Emmainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T01:33:50Zoai:estudogeral.uc.pt:10316/10431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:16.954380Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
title Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
spellingShingle Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
Costa-Balogh, Fátima O.
title_short Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
title_full Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
title_fullStr Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
title_full_unstemmed Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
title_sort Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
author Costa-Balogh, Fátima O.
author_facet Costa-Balogh, Fátima O.
Åberg, Christoffer
Sousa, João J. S.
Sparr, Emma
author_role author
author2 Åberg, Christoffer
Sousa, João J. S.
Sparr, Emma
author2_role author
author
author
dc.contributor.author.fl_str_mv Costa-Balogh, Fátima O.
Åberg, Christoffer
Sousa, João J. S.
Sparr, Emma
description In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.
publishDate 2005
dc.date.none.fl_str_mv 2005-11-08
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/10431
http://hdl.handle.net/10316/10431
https://doi.org/10.1021/la051947n
url http://hdl.handle.net/10316/10431
https://doi.org/10.1021/la051947n
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Langmuir. 21:23 (2005) 10307-10310
0743-7463
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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