Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/10431 https://doi.org/10.1021/la051947n |
Resumo: | In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations. |
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Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic GradientIn this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.American Chemical Society2005-11-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/10431http://hdl.handle.net/10316/10431https://doi.org/10.1021/la051947nengLangmuir. 21:23 (2005) 10307-103100743-7463Costa-Balogh, Fátima O.Åberg, ChristofferSousa, João J. S.Sparr, Emmainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2020-05-25T01:33:50Zoai:estudogeral.uc.pt:10316/10431Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:47:16.954380Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
title |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
spellingShingle |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient Costa-Balogh, Fátima O. |
title_short |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
title_full |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
title_fullStr |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
title_full_unstemmed |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
title_sort |
Drug Transport in Responding Lipid Membranes Can Be Regulated by an External Osmotic Gradient |
author |
Costa-Balogh, Fátima O. |
author_facet |
Costa-Balogh, Fátima O. Åberg, Christoffer Sousa, João J. S. Sparr, Emma |
author_role |
author |
author2 |
Åberg, Christoffer Sousa, João J. S. Sparr, Emma |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Costa-Balogh, Fátima O. Åberg, Christoffer Sousa, João J. S. Sparr, Emma |
description |
In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-11-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/10431 http://hdl.handle.net/10316/10431 https://doi.org/10.1021/la051947n |
url |
http://hdl.handle.net/10316/10431 https://doi.org/10.1021/la051947n |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Langmuir. 21:23 (2005) 10307-10310 0743-7463 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133750069559296 |