Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration

• Autor(a) principal: Afonso, Marta Cristina Valério
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.6/6634
• topic: Antioxidants; Oxidative Stress; Parkinson Disease; Domínio/Área Científica::Engenharia e Tecnologia:: Outras Engenharias e Tecnologias

Parkinson’s disease (PD) is a neurological disorder characterized by the degeneration of the nigrostriatal pathway and the consequent decrease levels of dopamine production, leading to both motor and non-motor symptoms. Although the exact cause behind the development of PD pathogenesis is not clarify, it is known that several factors individually or in combination, may have a role, being why this pathology is known to have a multifactorial etiology. Nevertheless, increased levels of oxidative stress have been described as a strong contributor factor to PD development. In this line, antioxidant compounds may be of great help to prevent the deleterious effect of oxidative stress on dopaminergic neurons and so capable to halt the progression of the disease. [...]