Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/6634 |
Resumo: | Parkinson’s disease (PD) is a neurological disorder characterized by the degeneration of the nigrostriatal pathway and the consequent decrease levels of dopamine production, leading to both motor and non-motor symptoms. Although the exact cause behind the development of PD pathogenesis is not clarify, it is known that several factors individually or in combination, may have a role, being why this pathology is known to have a multifactorial etiology. Nevertheless, increased levels of oxidative stress have been described as a strong contributor factor to PD development. In this line, antioxidant compounds may be of great help to prevent the deleterious effect of oxidative stress on dopaminergic neurons and so capable to halt the progression of the disease. [...] |
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Testing the application of new antioxidant chemical formulations to prevent neuronal degenerationAntioxidantsOxidative StressParkinson DiseaseDomínio/Área Científica::Engenharia e Tecnologia:: Outras Engenharias e TecnologiasParkinson’s disease (PD) is a neurological disorder characterized by the degeneration of the nigrostriatal pathway and the consequent decrease levels of dopamine production, leading to both motor and non-motor symptoms. Although the exact cause behind the development of PD pathogenesis is not clarify, it is known that several factors individually or in combination, may have a role, being why this pathology is known to have a multifactorial etiology. Nevertheless, increased levels of oxidative stress have been described as a strong contributor factor to PD development. In this line, antioxidant compounds may be of great help to prevent the deleterious effect of oxidative stress on dopaminergic neurons and so capable to halt the progression of the disease. [...]A doença de Parkinson é uma doença neurológica caracterizada pela degeneração da via nigrostriatal e pela consequente diminuição dos níveis de dopamina produzidos levando a sintomas motores e não motores. Embora a causa exata por trás do desenvolvimento desta doença não estar esclarecida, é sabida da existência de vários fatores que individualmente ou combinados têm uma função, justificando o porque desta patologia ter uma etiologia multifactorial. Em todo o caso, níveis elevados de stress oxidativo têm sido descritos como um fator com fortes contribuições para o desenvolvimento da doença de Parkinson. Neste sentido, os compostos antioxidantes têm sido uma grande ajuda na prevenção dos efeitos deletérios do stress oxidativo nos neurónios dopaminérgicos e capazes de parar a progressão da doença. [...]Cristóvão, Ana Clara BrazSousa, Ana CatarinauBibliorumAfonso, Marta Cristina Valério2024-02-03T01:30:46Z2017-10-32017-11-072017-11-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10400.6/6634TID:202028500porinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:57Zoai:ubibliorum.ubi.pt:10400.6/6634Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:47:18.906976Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
title |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
spellingShingle |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration Afonso, Marta Cristina Valério Antioxidants Oxidative Stress Parkinson Disease Domínio/Área Científica::Engenharia e Tecnologia:: Outras Engenharias e Tecnologias |
title_short |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
title_full |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
title_fullStr |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
title_full_unstemmed |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
title_sort |
Testing the application of new antioxidant chemical formulations to prevent neuronal degeneration |
author |
Afonso, Marta Cristina Valério |
author_facet |
Afonso, Marta Cristina Valério |
author_role |
author |
dc.contributor.none.fl_str_mv |
Cristóvão, Ana Clara Braz Sousa, Ana Catarina uBibliorum |
dc.contributor.author.fl_str_mv |
Afonso, Marta Cristina Valério |
dc.subject.por.fl_str_mv |
Antioxidants Oxidative Stress Parkinson Disease Domínio/Área Científica::Engenharia e Tecnologia:: Outras Engenharias e Tecnologias |
topic |
Antioxidants Oxidative Stress Parkinson Disease Domínio/Área Científica::Engenharia e Tecnologia:: Outras Engenharias e Tecnologias |
description |
Parkinson’s disease (PD) is a neurological disorder characterized by the degeneration of the nigrostriatal pathway and the consequent decrease levels of dopamine production, leading to both motor and non-motor symptoms. Although the exact cause behind the development of PD pathogenesis is not clarify, it is known that several factors individually or in combination, may have a role, being why this pathology is known to have a multifactorial etiology. Nevertheless, increased levels of oxidative stress have been described as a strong contributor factor to PD development. In this line, antioxidant compounds may be of great help to prevent the deleterious effect of oxidative stress on dopaminergic neurons and so capable to halt the progression of the disease. [...] |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-3 2017-11-07 2017-11-07T00:00:00Z 2024-02-03T01:30:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/6634 TID:202028500 |
url |
http://hdl.handle.net/10400.6/6634 |
identifier_str_mv |
TID:202028500 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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