Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota

Detalhes bibliográficos
Autor(a) principal: Thompson, Jessica Ann
Data de Publicação: 2015
Outros Autores: Oliveira, Rita Almeida, Djukovic, Ana, Ubeda, Carles, Xavier, Karina Bivar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/762
Resumo: The uploaded pdf article contains attached the supplementary files.
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spelling Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut MicrobiotaAnimalsAnti-Bacterial AgentsBacteroidetesEscherichia coliHomoserineIntestinesLactonesMaleMiceMice, Inbred C57BLMicrobiotaStaphylococcaceaeStreptomycinQuorum SensingThe uploaded pdf article contains attached the supplementary files.The mammalian gut microbiota harbors a diverse ecosystem where hundreds of bacterial species interact with each other and their host. Given that bacteria use signals to communicate and regulate group behaviors (quorum sensing), we asked whether such communication between different commensal species can influence the interactions occurring in this environment. We engineered the enteric bacterium, Escherichia coli, to manipulate the levels of the interspecies quorum sensing signal, autoinducer-2 (AI-2), in the mouse intestine and investigated the effect upon antibiotic-induced gut microbiota dysbiosis. E. coli that increased intestinal AI-2 levels altered the composition of the antibiotic-treated gut microbiota, favoring the expansion of the Firmicutes phylum. This significantly increased the Firmicutes/Bacteroidetes ratio, to oppose the strong effect of the antibiotic, which had almost cleared the Firmicutes. This demonstrates that AI-2 levels influence the abundance of the major phyla of the gut microbiota, the balance of which is known to influence human health.Howard Hughes Medical Institute - International Early Career Scientist grant: (HHMI 55007436); Ministerio de Ciencia e Innovacion grant: (MICINN; SAF2011-2945).ElsevierARCAThompson, Jessica AnnOliveira, Rita AlmeidaDjukovic, AnaUbeda, CarlesXavier, Karina Bivar2017-05-29T13:54:36Z2015-03-242015-03-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/762engJessica Ann Thompson, Rita Almeida Oliveira, Ana Djukovic, Carles Ubeda, Karina Bivar Xavier, Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota, Cell Reports, Volume 10, Issue 11, 24 March 2015, Pages 1861-1871, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2015.02.049. (http://www.sciencedirect.com/science/article/pii/S2211124715002077)10.1016/j.celrep.2015.02.049info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:09Zoai:arca.igc.gulbenkian.pt:10400.7/762Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:59.313946Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
title Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
spellingShingle Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
Thompson, Jessica Ann
Animals
Anti-Bacterial Agents
Bacteroidetes
Escherichia coli
Homoserine
Intestines
Lactones
Male
Mice
Mice, Inbred C57BL
Microbiota
Staphylococcaceae
Streptomycin
Quorum Sensing
title_short Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
title_full Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
title_fullStr Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
title_full_unstemmed Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
title_sort Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota
author Thompson, Jessica Ann
author_facet Thompson, Jessica Ann
Oliveira, Rita Almeida
Djukovic, Ana
Ubeda, Carles
Xavier, Karina Bivar
author_role author
author2 Oliveira, Rita Almeida
Djukovic, Ana
Ubeda, Carles
Xavier, Karina Bivar
author2_role author
author
author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Thompson, Jessica Ann
Oliveira, Rita Almeida
Djukovic, Ana
Ubeda, Carles
Xavier, Karina Bivar
dc.subject.por.fl_str_mv Animals
Anti-Bacterial Agents
Bacteroidetes
Escherichia coli
Homoserine
Intestines
Lactones
Male
Mice
Mice, Inbred C57BL
Microbiota
Staphylococcaceae
Streptomycin
Quorum Sensing
topic Animals
Anti-Bacterial Agents
Bacteroidetes
Escherichia coli
Homoserine
Intestines
Lactones
Male
Mice
Mice, Inbred C57BL
Microbiota
Staphylococcaceae
Streptomycin
Quorum Sensing
description The uploaded pdf article contains attached the supplementary files.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-24
2015-03-24T00:00:00Z
2017-05-29T13:54:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/762
url http://hdl.handle.net/10400.7/762
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jessica Ann Thompson, Rita Almeida Oliveira, Ana Djukovic, Carles Ubeda, Karina Bivar Xavier, Manipulation of the Quorum Sensing Signal AI-2 Affects the Antibiotic-Treated Gut Microbiota, Cell Reports, Volume 10, Issue 11, 24 March 2015, Pages 1861-1871, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2015.02.049. (http://www.sciencedirect.com/science/article/pii/S2211124715002077)
10.1016/j.celrep.2015.02.049
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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