Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells

Detalhes bibliográficos
Autor(a) principal: Rosa, Ricardo
Data de Publicação: 2006
Outros Autores: Marques, Cláudia, Rodrigues, Olivia Roos, Santos-Gomes, Gabriela M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/157433
Resumo: Funding Information: The authors thank J.M. Cristóvão and J. Ramada for technical assistance. Funding for this work was provided by the project research grant POCTI/CVT/37759/2001 by the Fundação para a Ciência e Tecnologia (FCT), Portugal partially supported by the European Union Fund (FEDER), and grant SFRH/BD/997/2000 from FCT.
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spelling Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cellsCD4 T cellsCD8 T cellsCytokineL. infantum released proteinsRodent modelRA0421 Public health. Hygiene. Preventive MedicineQR MicrobiologyQR180 ImmunologyParasitologyveterinary (miscalleneous)Insect ScienceInfectious DiseasesImmunology and Microbiology (miscellaneous)SDG 1 - No PovertySDG 3 - Good Health and Well-beingFunding Information: The authors thank J.M. Cristóvão and J. Ramada for technical assistance. Funding for this work was provided by the project research grant POCTI/CVT/37759/2001 by the Fundação para a Ciência e Tecnologia (FCT), Portugal partially supported by the European Union Fund (FEDER), and grant SFRH/BD/997/2000 from FCT.Specific immune responses by CD4+ and CD8+ T cells, from two infected mice strains (BALB/c and C57BL/6), induced by High, Inter and Low protein fractions released by Leishmania infantum, were assessed through the evaluation of IL-12, IFN-γ and IL-10 mRNA by real-time PCR and respective protein production by ELISA. During infection establishment, High and Inter fractions directed both mice strains T cells subsets to increase the production of IFN-γ, associated to IL-12 release. Later on, parasite replication augmented in BALB/c and stabilised in C57BL/6 mice. Inter fraction induced CD4+ T cells to maintain IFN-γ production, with the simultaneous release of IL-12 by both cell subsets in BALB/c mice and by CD8+ T cells in C57BL/6 mice. These observations suggested a prophylactic potential for Inter fraction which was able to induce Th1 response with IL-12 involvement, required for the maintenance of memory cells, in mice strains with different parasitic evolution.Instituto de Higiene e Medicina Tropical (IHMT)RUNRosa, RicardoMarques, CláudiaRodrigues, Olivia RoosSantos-Gomes, Gabriela M.2023-09-05T22:16:45Z2006-032006-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/157433eng0001-706XPURE: 70714338https://doi.org/10.1016/j.actatropica.2005.12.003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:39:45Zoai:run.unl.pt:10362/157433Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:44.719504Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
title Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
spellingShingle Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
Rosa, Ricardo
CD4 T cells
CD8 T cells
Cytokine
L. infantum released proteins
Rodent model
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
QR180 Immunology
Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases
Immunology and Microbiology (miscellaneous)
SDG 1 - No Poverty
SDG 3 - Good Health and Well-being
title_short Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
title_full Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
title_fullStr Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
title_full_unstemmed Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
title_sort Leishmania infantum released proteins specifically regulate cytokine expression and production patterns by CD4+ and CD8+ T cells
author Rosa, Ricardo
author_facet Rosa, Ricardo
Marques, Cláudia
Rodrigues, Olivia Roos
Santos-Gomes, Gabriela M.
author_role author
author2 Marques, Cláudia
Rodrigues, Olivia Roos
Santos-Gomes, Gabriela M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
RUN
dc.contributor.author.fl_str_mv Rosa, Ricardo
Marques, Cláudia
Rodrigues, Olivia Roos
Santos-Gomes, Gabriela M.
dc.subject.por.fl_str_mv CD4 T cells
CD8 T cells
Cytokine
L. infantum released proteins
Rodent model
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
QR180 Immunology
Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases
Immunology and Microbiology (miscellaneous)
SDG 1 - No Poverty
SDG 3 - Good Health and Well-being
topic CD4 T cells
CD8 T cells
Cytokine
L. infantum released proteins
Rodent model
RA0421 Public health. Hygiene. Preventive Medicine
QR Microbiology
QR180 Immunology
Parasitology
veterinary (miscalleneous)
Insect Science
Infectious Diseases
Immunology and Microbiology (miscellaneous)
SDG 1 - No Poverty
SDG 3 - Good Health and Well-being
description Funding Information: The authors thank J.M. Cristóvão and J. Ramada for technical assistance. Funding for this work was provided by the project research grant POCTI/CVT/37759/2001 by the Fundação para a Ciência e Tecnologia (FCT), Portugal partially supported by the European Union Fund (FEDER), and grant SFRH/BD/997/2000 from FCT.
publishDate 2006
dc.date.none.fl_str_mv 2006-03
2006-03-01T00:00:00Z
2023-09-05T22:16:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/157433
url http://hdl.handle.net/10362/157433
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0001-706X
PURE: 70714338
https://doi.org/10.1016/j.actatropica.2005.12.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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